Copy number variation in the CES1 gene and the risk of non-alcoholic fatty liver in a Chinese Han population

Abstract A recent genome-wide copy number variations (CNVs) scan identified a 16q12.2 deletion that included the carboxylesterase 1 (CES1) gene, which is important in the metabolism of fatty acids and cholesterol. We aimed to investigate whether CES1 CNVs was associated with susceptibility to non-al...

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Autores principales:	Bing bing Chen, Jian hui Yan, Jing Zheng, He wei Peng, Xiao ling Cai, Xin ting Pan, Hui quan Li, Qi zhu Hong, Xian-E Peng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1a09fd8150914b27a2f876422b3b7a3f
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spelling	oai:doaj.org-article:1a09fd8150914b27a2f876422b3b7a3f2021-12-02T16:15:07ZCopy number variation in the CES1 gene and the risk of non-alcoholic fatty liver in a Chinese Han population10.1038/s41598-021-93549-22045-2322https://doaj.org/article/1a09fd8150914b27a2f876422b3b7a3f2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93549-2https://doaj.org/toc/2045-2322Abstract A recent genome-wide copy number variations (CNVs) scan identified a 16q12.2 deletion that included the carboxylesterase 1 (CES1) gene, which is important in the metabolism of fatty acids and cholesterol. We aimed to investigate whether CES1 CNVs was associated with susceptibility to non-alcoholic fatty liver disease (NAFLD) in a Chinese Han population. A case–control study was conducted among 303 patients diagnosed with NAFLD and 303 age (± 5) and sex-matched controls from the Affiliated Nanping First Hospital of Fujian Medical University in China. The copy numbers of CES1 were measured using TaqMan quantitative real-time polymerase chain reaction (qPCR) and serum CES1 was measured using enzyme-linked immunosorbent assays. The Chi-squared test and a logistic regression model were used to evaluate the association between CES1 CNVs and NAFLD susceptibility. The distribution of CES1 CNVs showed a higher frequency of CNVs loss (< 2) among patients; however, the difference was not significant (P = 0.05). After controlling for other known or suspected risk factors for NAFLD, CES1 CNVs loss was significantly associated with greater risk of NAFLD (adjusted OR = 2.75, 95% CI 1.30–5.85, P = 0.01); while CES1 CNVs gain (> 2) was not. There was a suggestion of an association between increased CES1 serum protein levels and CNVs losses among cases, although this was not statistically significant (P = 0.07). Copy number losses (< 2) of CES1 contribute to susceptibility to NAFLD in the Chinese Han population.Bing bing ChenJian hui YanJing ZhengHe wei PengXiao ling CaiXin ting PanHui quan LiQi zhu HongXian-E PengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bing bing Chen Jian hui Yan Jing Zheng He wei Peng Xiao ling Cai Xin ting Pan Hui quan Li Qi zhu Hong Xian-E Peng Copy number variation in the CES1 gene and the risk of non-alcoholic fatty liver in a Chinese Han population
description	Abstract A recent genome-wide copy number variations (CNVs) scan identified a 16q12.2 deletion that included the carboxylesterase 1 (CES1) gene, which is important in the metabolism of fatty acids and cholesterol. We aimed to investigate whether CES1 CNVs was associated with susceptibility to non-alcoholic fatty liver disease (NAFLD) in a Chinese Han population. A case–control study was conducted among 303 patients diagnosed with NAFLD and 303 age (± 5) and sex-matched controls from the Affiliated Nanping First Hospital of Fujian Medical University in China. The copy numbers of CES1 were measured using TaqMan quantitative real-time polymerase chain reaction (qPCR) and serum CES1 was measured using enzyme-linked immunosorbent assays. The Chi-squared test and a logistic regression model were used to evaluate the association between CES1 CNVs and NAFLD susceptibility. The distribution of CES1 CNVs showed a higher frequency of CNVs loss (< 2) among patients; however, the difference was not significant (P = 0.05). After controlling for other known or suspected risk factors for NAFLD, CES1 CNVs loss was significantly associated with greater risk of NAFLD (adjusted OR = 2.75, 95% CI 1.30–5.85, P = 0.01); while CES1 CNVs gain (> 2) was not. There was a suggestion of an association between increased CES1 serum protein levels and CNVs losses among cases, although this was not statistically significant (P = 0.07). Copy number losses (< 2) of CES1 contribute to susceptibility to NAFLD in the Chinese Han population.
format	article
author	Bing bing Chen Jian hui Yan Jing Zheng He wei Peng Xiao ling Cai Xin ting Pan Hui quan Li Qi zhu Hong Xian-E Peng
author_facet	Bing bing Chen Jian hui Yan Jing Zheng He wei Peng Xiao ling Cai Xin ting Pan Hui quan Li Qi zhu Hong Xian-E Peng
author_sort	Bing bing Chen
title	Copy number variation in the CES1 gene and the risk of non-alcoholic fatty liver in a Chinese Han population
title_short	Copy number variation in the CES1 gene and the risk of non-alcoholic fatty liver in a Chinese Han population
title_full	Copy number variation in the CES1 gene and the risk of non-alcoholic fatty liver in a Chinese Han population
title_fullStr	Copy number variation in the CES1 gene and the risk of non-alcoholic fatty liver in a Chinese Han population
title_full_unstemmed	Copy number variation in the CES1 gene and the risk of non-alcoholic fatty liver in a Chinese Han population
title_sort	copy number variation in the ces1 gene and the risk of non-alcoholic fatty liver in a chinese han population
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1a09fd8150914b27a2f876422b3b7a3f
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Copy number variation in the CES1 gene and the risk of non-alcoholic fatty liver in a Chinese Han population

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