Effects of Ginkgo leaf tablets on the pharmacokinetics of atovastatin in rats

Context: Ginkgo leaf tablets (GLT), an effective traditional Chinese multi-herbal formula, are often combined with atorvastatin calcium (AC) for treating coronary heart disease in clinic. Objective: This study investigated the effects of GLT on the pharmacokinetics of AC and the potential mechanism....

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Autores principales:	Yan Ren, Haifeng Li, Xing Liu
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2019
Materias:	herb-drug interaction metabolism coronary heart disease Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/1a0f2439c553406ebd1adcb28893eab9
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spelling	oai:doaj.org-article:1a0f2439c553406ebd1adcb28893eab92021-11-17T14:21:56ZEffects of Ginkgo leaf tablets on the pharmacokinetics of atovastatin in rats1388-02091744-511610.1080/13880209.2019.1622569https://doaj.org/article/1a0f2439c553406ebd1adcb28893eab92019-01-01T00:00:00Zhttp://dx.doi.org/10.1080/13880209.2019.1622569https://doaj.org/toc/1388-0209https://doaj.org/toc/1744-5116Context: Ginkgo leaf tablets (GLT), an effective traditional Chinese multi-herbal formula, are often combined with atorvastatin calcium (AC) for treating coronary heart disease in clinic. Objective: This study investigated the effects of GLT on the pharmacokinetics of AC and the potential mechanism. Materials and methods: The pharmacokinetics of AC (oral administered at a dose of 1 mg/kg) with or without pre-treatment of GLT (oral administered at a dose of 80 mg/kg/day for 10 days) were investigated in male Sprague–Dawley rats. The effects of GLT on the metabolic stability of AC were also investigated using rat liver microsome incubation systems. Results: The results indicated that the Cmax increased from 36.84 ± 4.21 to 48.68 ± 6.35 ng/mL, and the AUC(0-t) increased from 135.82 ± 21.05 to 77.28 ± 12.92 ng h/mL, and t1/2 also increased from 2.62 ± 0.31 to 3.32 ± 0.57 h when GLT and AC were co-administered. The metabolic stability of AC was also increased (48.2 ± 6.7 vs. 36.7 ± 5.3 min) with the pre-treatment of GLT. Discussion: This study indicated that the main components in GLT could accelerate the metabolism of AC in rat liver microsomes and change the pharmacokinetic behaviours of AC. So these results showed that the herb-drug interaction between GLT and AC might occur, and the clinical efficacy could increase when they were co-administered. Therefore, the clinical dose of AC should be decreased when GLT and AC are co-administered.Yan RenHaifeng LiXing LiuTaylor & Francis Grouparticleherb-drug interactionmetabolismcoronary heart diseaseTherapeutics. PharmacologyRM1-950ENPharmaceutical Biology, Vol 57, Iss 1, Pp 403-406 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	herb-drug interaction metabolism coronary heart disease Therapeutics. Pharmacology RM1-950
spellingShingle	herb-drug interaction metabolism coronary heart disease Therapeutics. Pharmacology RM1-950 Yan Ren Haifeng Li Xing Liu Effects of Ginkgo leaf tablets on the pharmacokinetics of atovastatin in rats
description	Context: Ginkgo leaf tablets (GLT), an effective traditional Chinese multi-herbal formula, are often combined with atorvastatin calcium (AC) for treating coronary heart disease in clinic. Objective: This study investigated the effects of GLT on the pharmacokinetics of AC and the potential mechanism. Materials and methods: The pharmacokinetics of AC (oral administered at a dose of 1 mg/kg) with or without pre-treatment of GLT (oral administered at a dose of 80 mg/kg/day for 10 days) were investigated in male Sprague–Dawley rats. The effects of GLT on the metabolic stability of AC were also investigated using rat liver microsome incubation systems. Results: The results indicated that the Cmax increased from 36.84 ± 4.21 to 48.68 ± 6.35 ng/mL, and the AUC(0-t) increased from 135.82 ± 21.05 to 77.28 ± 12.92 ng h/mL, and t1/2 also increased from 2.62 ± 0.31 to 3.32 ± 0.57 h when GLT and AC were co-administered. The metabolic stability of AC was also increased (48.2 ± 6.7 vs. 36.7 ± 5.3 min) with the pre-treatment of GLT. Discussion: This study indicated that the main components in GLT could accelerate the metabolism of AC in rat liver microsomes and change the pharmacokinetic behaviours of AC. So these results showed that the herb-drug interaction between GLT and AC might occur, and the clinical efficacy could increase when they were co-administered. Therefore, the clinical dose of AC should be decreased when GLT and AC are co-administered.
format	article
author	Yan Ren Haifeng Li Xing Liu
author_facet	Yan Ren Haifeng Li Xing Liu
author_sort	Yan Ren
title	Effects of Ginkgo leaf tablets on the pharmacokinetics of atovastatin in rats
title_short	Effects of Ginkgo leaf tablets on the pharmacokinetics of atovastatin in rats
title_full	Effects of Ginkgo leaf tablets on the pharmacokinetics of atovastatin in rats
title_fullStr	Effects of Ginkgo leaf tablets on the pharmacokinetics of atovastatin in rats
title_full_unstemmed	Effects of Ginkgo leaf tablets on the pharmacokinetics of atovastatin in rats
title_sort	effects of ginkgo leaf tablets on the pharmacokinetics of atovastatin in rats
publisher	Taylor & Francis Group
publishDate	2019
url	https://doaj.org/article/1a0f2439c553406ebd1adcb28893eab9
work_keys_str_mv	AT yanren effectsofginkgoleaftabletsonthepharmacokineticsofatovastatininrats AT haifengli effectsofginkgoleaftabletsonthepharmacokineticsofatovastatininrats AT xingliu effectsofginkgoleaftabletsonthepharmacokineticsofatovastatininrats
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Effects of Ginkgo leaf tablets on the pharmacokinetics of atovastatin in rats

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