Targeting GLP-1 receptor trafficking to improve agonist efficacy

Glucagon-like peptide-1 receptor (GLP-1R) promotes insulin secretion from pancreatic beta cells and undergoes agonist-mediated endocytosis. Here, authors study GLP-1R endocytosis caused by different agonists and show that a longer plasma membrane retention time of GLP-1R results in greater long-term...

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Autores principales:	Ben Jones, Teresa Buenaventura, Nisha Kanda, Pauline Chabosseau, Bryn M. Owen, Rebecca Scott, Robert Goldin, Napat Angkathunyakul, Ivan R. Corrêa Jr, Domenico Bosco, Paul R. Johnson, Lorenzo Piemonti, Piero Marchetti, A. M. James Shapiro, Blake J. Cochran, Aylin C. Hanyaloglu, Asuka Inoue, Tricia Tan, Guy A. Rutter, Alejandra Tomas, Stephen R. Bloom
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1a1126743c294faca93a0169f9e7cb17
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:1a1126743c294faca93a0169f9e7cb172021-12-02T17:31:16ZTargeting GLP-1 receptor trafficking to improve agonist efficacy10.1038/s41467-018-03941-22041-1723https://doaj.org/article/1a1126743c294faca93a0169f9e7cb172018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03941-2https://doaj.org/toc/2041-1723Glucagon-like peptide-1 receptor (GLP-1R) promotes insulin secretion from pancreatic beta cells and undergoes agonist-mediated endocytosis. Here, authors study GLP-1R endocytosis caused by different agonists and show that a longer plasma membrane retention time of GLP-1R results in greater long-term insulin release.Ben JonesTeresa BuenaventuraNisha KandaPauline ChabosseauBryn M. OwenRebecca ScottRobert GoldinNapat AngkathunyakulIvan R. Corrêa JrDomenico BoscoPaul R. JohnsonLorenzo PiemontiPiero MarchettiA. M. James ShapiroBlake J. CochranAylin C. HanyalogluAsuka InoueTricia TanGuy A. RutterAlejandra TomasStephen R. BloomNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ben Jones Teresa Buenaventura Nisha Kanda Pauline Chabosseau Bryn M. Owen Rebecca Scott Robert Goldin Napat Angkathunyakul Ivan R. Corrêa Jr Domenico Bosco Paul R. Johnson Lorenzo Piemonti Piero Marchetti A. M. James Shapiro Blake J. Cochran Aylin C. Hanyaloglu Asuka Inoue Tricia Tan Guy A. Rutter Alejandra Tomas Stephen R. Bloom Targeting GLP-1 receptor trafficking to improve agonist efficacy
description	Glucagon-like peptide-1 receptor (GLP-1R) promotes insulin secretion from pancreatic beta cells and undergoes agonist-mediated endocytosis. Here, authors study GLP-1R endocytosis caused by different agonists and show that a longer plasma membrane retention time of GLP-1R results in greater long-term insulin release.
format	article
author	Ben Jones Teresa Buenaventura Nisha Kanda Pauline Chabosseau Bryn M. Owen Rebecca Scott Robert Goldin Napat Angkathunyakul Ivan R. Corrêa Jr Domenico Bosco Paul R. Johnson Lorenzo Piemonti Piero Marchetti A. M. James Shapiro Blake J. Cochran Aylin C. Hanyaloglu Asuka Inoue Tricia Tan Guy A. Rutter Alejandra Tomas Stephen R. Bloom
author_facet	Ben Jones Teresa Buenaventura Nisha Kanda Pauline Chabosseau Bryn M. Owen Rebecca Scott Robert Goldin Napat Angkathunyakul Ivan R. Corrêa Jr Domenico Bosco Paul R. Johnson Lorenzo Piemonti Piero Marchetti A. M. James Shapiro Blake J. Cochran Aylin C. Hanyaloglu Asuka Inoue Tricia Tan Guy A. Rutter Alejandra Tomas Stephen R. Bloom
author_sort	Ben Jones
title	Targeting GLP-1 receptor trafficking to improve agonist efficacy
title_short	Targeting GLP-1 receptor trafficking to improve agonist efficacy
title_full	Targeting GLP-1 receptor trafficking to improve agonist efficacy
title_fullStr	Targeting GLP-1 receptor trafficking to improve agonist efficacy
title_full_unstemmed	Targeting GLP-1 receptor trafficking to improve agonist efficacy
title_sort	targeting glp-1 receptor trafficking to improve agonist efficacy
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/1a1126743c294faca93a0169f9e7cb17
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Targeting GLP-1 receptor trafficking to improve agonist efficacy

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