Constructing a synthetic pathway for acetyl-coenzyme A from one-carbon through enzyme design

The microbial synthesis of carbon-containing compounds from single carbon precursors is desirable, yet designed pathways to achieve this goal overlap with host metabolism. Here the authors design a de novo metabolic pathway to assimilate formaldehyde into acetyl-CoA that does not overlap with known...

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Autores principales:	Xiaoyun Lu, Yuwan Liu, Yiqun Yang, Shanshan Wang, Qian Wang, Xiya Wang, Zhihui Yan, Jian Cheng, Cui Liu, Xue Yang, Hao Luo, Sheng Yang, Junran Gou, Luzhen Ye, Lina Lu, Zhidan Zhang, Yu Guo, Yan Nie, Jianping Lin, Sheng Li, Chaoguang Tian, Tao Cai, Bingzhao Zhuo, Hongwu Ma, Wen Wang, Yanhe Ma, Yongjun Liu, Yin Li, Huifeng Jiang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1a13a3c2908242da81c5fcbabe166587
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spelling	oai:doaj.org-article:1a13a3c2908242da81c5fcbabe1665872021-12-02T15:36:23ZConstructing a synthetic pathway for acetyl-coenzyme A from one-carbon through enzyme design10.1038/s41467-019-09095-z2041-1723https://doaj.org/article/1a13a3c2908242da81c5fcbabe1665872019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09095-zhttps://doaj.org/toc/2041-1723The microbial synthesis of carbon-containing compounds from single carbon precursors is desirable, yet designed pathways to achieve this goal overlap with host metabolism. Here the authors design a de novo metabolic pathway to assimilate formaldehyde into acetyl-CoA that does not overlap with known metabolic networks.Xiaoyun LuYuwan LiuYiqun YangShanshan WangQian WangXiya WangZhihui YanJian ChengCui LiuXue YangHao LuoSheng YangJunran GouLuzhen YeLina LuZhidan ZhangYu GuoYan NieJianping LinSheng LiChaoguang TianTao CaiBingzhao ZhuoHongwu MaWen WangYanhe MaYongjun LiuYin LiHuifeng JiangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaoyun Lu Yuwan Liu Yiqun Yang Shanshan Wang Qian Wang Xiya Wang Zhihui Yan Jian Cheng Cui Liu Xue Yang Hao Luo Sheng Yang Junran Gou Luzhen Ye Lina Lu Zhidan Zhang Yu Guo Yan Nie Jianping Lin Sheng Li Chaoguang Tian Tao Cai Bingzhao Zhuo Hongwu Ma Wen Wang Yanhe Ma Yongjun Liu Yin Li Huifeng Jiang Constructing a synthetic pathway for acetyl-coenzyme A from one-carbon through enzyme design
description	The microbial synthesis of carbon-containing compounds from single carbon precursors is desirable, yet designed pathways to achieve this goal overlap with host metabolism. Here the authors design a de novo metabolic pathway to assimilate formaldehyde into acetyl-CoA that does not overlap with known metabolic networks.
format	article
author	Xiaoyun Lu Yuwan Liu Yiqun Yang Shanshan Wang Qian Wang Xiya Wang Zhihui Yan Jian Cheng Cui Liu Xue Yang Hao Luo Sheng Yang Junran Gou Luzhen Ye Lina Lu Zhidan Zhang Yu Guo Yan Nie Jianping Lin Sheng Li Chaoguang Tian Tao Cai Bingzhao Zhuo Hongwu Ma Wen Wang Yanhe Ma Yongjun Liu Yin Li Huifeng Jiang
author_facet	Xiaoyun Lu Yuwan Liu Yiqun Yang Shanshan Wang Qian Wang Xiya Wang Zhihui Yan Jian Cheng Cui Liu Xue Yang Hao Luo Sheng Yang Junran Gou Luzhen Ye Lina Lu Zhidan Zhang Yu Guo Yan Nie Jianping Lin Sheng Li Chaoguang Tian Tao Cai Bingzhao Zhuo Hongwu Ma Wen Wang Yanhe Ma Yongjun Liu Yin Li Huifeng Jiang
author_sort	Xiaoyun Lu
title	Constructing a synthetic pathway for acetyl-coenzyme A from one-carbon through enzyme design
title_short	Constructing a synthetic pathway for acetyl-coenzyme A from one-carbon through enzyme design
title_full	Constructing a synthetic pathway for acetyl-coenzyme A from one-carbon through enzyme design
title_fullStr	Constructing a synthetic pathway for acetyl-coenzyme A from one-carbon through enzyme design
title_full_unstemmed	Constructing a synthetic pathway for acetyl-coenzyme A from one-carbon through enzyme design
title_sort	constructing a synthetic pathway for acetyl-coenzyme a from one-carbon through enzyme design
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/1a13a3c2908242da81c5fcbabe166587
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Constructing a synthetic pathway for acetyl-coenzyme A from one-carbon through enzyme design

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