Constructing a synthetic pathway for acetyl-coenzyme A from one-carbon through enzyme design

Constructing a synthetic pathway for acetyl-coenzyme A from one-carbon through enzyme design

The microbial synthesis of carbon-containing compounds from single carbon precursors is desirable, yet designed pathways to achieve this goal overlap with host metabolism. Here the authors design a de novo metabolic pathway to assimilate formaldehyde into acetyl-CoA that does not overlap with known...

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Autores principales: Xiaoyun Lu, Yuwan Liu, Yiqun Yang, Shanshan Wang, Qian Wang, Xiya Wang, Zhihui Yan, Jian Cheng, Cui Liu, Xue Yang, Hao Luo, Sheng Yang, Junran Gou, Luzhen Ye, Lina Lu, Zhidan Zhang, Yu Guo, Yan Nie, Jianping Lin, Sheng Li, Chaoguang Tian, Tao Cai, Bingzhao Zhuo, Hongwu Ma, Wen Wang, Yanhe Ma, Yongjun Liu, Yin Li, Huifeng Jiang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/1a13a3c2908242da81c5fcbabe166587
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