High-Resolution Imaging for the Analysis and Reconstruction of 3D Microenvironments for Regenerative Medicine: An Application-Focused Review

The rapid evolution of regenerative medicine and its associated scientific fields, such as tissue engineering, has provided great promise for multiple applications where replacement and regeneration of damaged or lost tissue is required. In order to evaluate and optimise the tissue engineering techn...

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Autores principales:	Michail E. Klontzas, Alexandros Protonotarios
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	tissue engineering regenerative medicine cardiovascular musculoskeletal neural MRI Technology T Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/1a14ad4de8464b3e805fddf481bb2052
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spelling	oai:doaj.org-article:1a14ad4de8464b3e805fddf481bb20522021-11-25T16:46:38ZHigh-Resolution Imaging for the Analysis and Reconstruction of 3D Microenvironments for Regenerative Medicine: An Application-Focused Review10.3390/bioengineering81101822306-5354https://doaj.org/article/1a14ad4de8464b3e805fddf481bb20522021-11-01T00:00:00Zhttps://www.mdpi.com/2306-5354/8/11/182https://doaj.org/toc/2306-5354The rapid evolution of regenerative medicine and its associated scientific fields, such as tissue engineering, has provided great promise for multiple applications where replacement and regeneration of damaged or lost tissue is required. In order to evaluate and optimise the tissue engineering techniques, visualisation of the material of interest is crucial. This includes monitoring of the cellular behaviour, extracellular matrix composition, scaffold structure, and other crucial elements of biomaterials. Non-invasive visualisation of artificial tissues is important at all stages of development and clinical translation. A variety of preclinical and clinical imaging methods—including confocal multiphoton microscopy, optical coherence tomography, magnetic resonance imaging (MRI), and computed tomography (CT)—have been used for the evaluation of artificial tissues. This review attempts to present the imaging methods available to assess the composition and quality of 3D microenvironments, as well as their integration with human tissues once implanted in the human body. The review provides tissue-specific application examples to demonstrate the applicability of such methods on cardiovascular, musculoskeletal, and neural tissue engineering.Michail E. KlontzasAlexandros ProtonotariosMDPI AGarticletissue engineeringregenerative medicinecardiovascularmusculoskeletalneuralMRITechnologyTBiology (General)QH301-705.5ENBioengineering, Vol 8, Iss 182, p 182 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	tissue engineering regenerative medicine cardiovascular musculoskeletal neural MRI Technology T Biology (General) QH301-705.5
spellingShingle	tissue engineering regenerative medicine cardiovascular musculoskeletal neural MRI Technology T Biology (General) QH301-705.5 Michail E. Klontzas Alexandros Protonotarios High-Resolution Imaging for the Analysis and Reconstruction of 3D Microenvironments for Regenerative Medicine: An Application-Focused Review
description	The rapid evolution of regenerative medicine and its associated scientific fields, such as tissue engineering, has provided great promise for multiple applications where replacement and regeneration of damaged or lost tissue is required. In order to evaluate and optimise the tissue engineering techniques, visualisation of the material of interest is crucial. This includes monitoring of the cellular behaviour, extracellular matrix composition, scaffold structure, and other crucial elements of biomaterials. Non-invasive visualisation of artificial tissues is important at all stages of development and clinical translation. A variety of preclinical and clinical imaging methods—including confocal multiphoton microscopy, optical coherence tomography, magnetic resonance imaging (MRI), and computed tomography (CT)—have been used for the evaluation of artificial tissues. This review attempts to present the imaging methods available to assess the composition and quality of 3D microenvironments, as well as their integration with human tissues once implanted in the human body. The review provides tissue-specific application examples to demonstrate the applicability of such methods on cardiovascular, musculoskeletal, and neural tissue engineering.
format	article
author	Michail E. Klontzas Alexandros Protonotarios
author_facet	Michail E. Klontzas Alexandros Protonotarios
author_sort	Michail E. Klontzas
title	High-Resolution Imaging for the Analysis and Reconstruction of 3D Microenvironments for Regenerative Medicine: An Application-Focused Review
title_short	High-Resolution Imaging for the Analysis and Reconstruction of 3D Microenvironments for Regenerative Medicine: An Application-Focused Review
title_full	High-Resolution Imaging for the Analysis and Reconstruction of 3D Microenvironments for Regenerative Medicine: An Application-Focused Review
title_fullStr	High-Resolution Imaging for the Analysis and Reconstruction of 3D Microenvironments for Regenerative Medicine: An Application-Focused Review
title_full_unstemmed	High-Resolution Imaging for the Analysis and Reconstruction of 3D Microenvironments for Regenerative Medicine: An Application-Focused Review
title_sort	high-resolution imaging for the analysis and reconstruction of 3d microenvironments for regenerative medicine: an application-focused review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1a14ad4de8464b3e805fddf481bb2052
work_keys_str_mv	AT michaileklontzas highresolutionimagingfortheanalysisandreconstructionof3dmicroenvironmentsforregenerativemedicineanapplicationfocusedreview AT alexandrosprotonotarios highresolutionimagingfortheanalysisandreconstructionof3dmicroenvironmentsforregenerativemedicineanapplicationfocusedreview
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High-Resolution Imaging for the Analysis and Reconstruction of 3D Microenvironments for Regenerative Medicine: An Application-Focused Review

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