Metastatic Lymph Node Ratio for Predicting Recurrence in Medullary Thyroid Cancer

The lymph node ratio (LNR) has been investigated as a prognostic factor in many different types of cancers, including differentiated thyroid cancer; however, reports regarding medullary thyroid cancer (MTC) are limited. Therefore, this study aims to evaluate LNR as a risk factor for structural recur...

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Autores principales:	Jinyoung Kim, Jun Park, Hyunju Park, Min Sun Choi, Hye Won Jang, Tae Hyuk Kim, Sun Wook Kim, Jae Hoon Chung
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	thyroid neoplasms prognosis lymph node ratio Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/1a1f239554f24959925ee599aeb9d6bc
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spelling	oai:doaj.org-article:1a1f239554f24959925ee599aeb9d6bc2021-11-25T17:04:38ZMetastatic Lymph Node Ratio for Predicting Recurrence in Medullary Thyroid Cancer10.3390/cancers132258422072-6694https://doaj.org/article/1a1f239554f24959925ee599aeb9d6bc2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5842https://doaj.org/toc/2072-6694The lymph node ratio (LNR) has been investigated as a prognostic factor in many different types of cancers, including differentiated thyroid cancer; however, reports regarding medullary thyroid cancer (MTC) are limited. Therefore, this study aims to evaluate LNR as a risk factor for structural recurrence in patients with MTC. Medical records of patients treated for MTC in a single tertiary center between 1995 and 2017 were retrospectively reviewed. LNR is defined as the number of metastatic lymph nodes or lymph node metastases (LNM) divided by the number of retrieved lymph nodes or lymph node yield (LNY). In the survival analysis, recurrence-free survival was defined as the time from the date of total thyroidectomy to recurrence or last follow-up. To identify risk factors influencing structural recurrence, univariable and multivariable Cox proportional hazard models were used. A total of 132 patients were enrolled. The mean age of study participants was 49.7 years, and 86 patients (65%) were women. Structural recurrence was identified in 39 patients at the end of the study period, and the median follow-up period was 8.7 years. In univariable analyses, gross extra thyroidal extension, N stage, postoperative serum calcitonin and carcinoembryonic antigen (CEA) levels, and LNR were significant (<i>p</i> < 0.05) predictors of structural recurrence. In multivariable analysis, postoperative serum calcitonin, postoperative serum CEA, and LNR were identified as a predictor of disease-free survival (<i>p</i> < 0.05). LNR can potentially predict structural recurrence as a quantitative evaluation tool for lymph node metastasis in patients with MTC.Jinyoung KimJun ParkHyunju ParkMin Sun ChoiHye Won JangTae Hyuk KimSun Wook KimJae Hoon ChungMDPI AGarticlethyroid neoplasmsprognosislymph node ratioNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5842, p 5842 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	thyroid neoplasms prognosis lymph node ratio Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	thyroid neoplasms prognosis lymph node ratio Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Jinyoung Kim Jun Park Hyunju Park Min Sun Choi Hye Won Jang Tae Hyuk Kim Sun Wook Kim Jae Hoon Chung Metastatic Lymph Node Ratio for Predicting Recurrence in Medullary Thyroid Cancer
description	The lymph node ratio (LNR) has been investigated as a prognostic factor in many different types of cancers, including differentiated thyroid cancer; however, reports regarding medullary thyroid cancer (MTC) are limited. Therefore, this study aims to evaluate LNR as a risk factor for structural recurrence in patients with MTC. Medical records of patients treated for MTC in a single tertiary center between 1995 and 2017 were retrospectively reviewed. LNR is defined as the number of metastatic lymph nodes or lymph node metastases (LNM) divided by the number of retrieved lymph nodes or lymph node yield (LNY). In the survival analysis, recurrence-free survival was defined as the time from the date of total thyroidectomy to recurrence or last follow-up. To identify risk factors influencing structural recurrence, univariable and multivariable Cox proportional hazard models were used. A total of 132 patients were enrolled. The mean age of study participants was 49.7 years, and 86 patients (65%) were women. Structural recurrence was identified in 39 patients at the end of the study period, and the median follow-up period was 8.7 years. In univariable analyses, gross extra thyroidal extension, N stage, postoperative serum calcitonin and carcinoembryonic antigen (CEA) levels, and LNR were significant (<i>p</i> < 0.05) predictors of structural recurrence. In multivariable analysis, postoperative serum calcitonin, postoperative serum CEA, and LNR were identified as a predictor of disease-free survival (<i>p</i> < 0.05). LNR can potentially predict structural recurrence as a quantitative evaluation tool for lymph node metastasis in patients with MTC.
format	article
author	Jinyoung Kim Jun Park Hyunju Park Min Sun Choi Hye Won Jang Tae Hyuk Kim Sun Wook Kim Jae Hoon Chung
author_facet	Jinyoung Kim Jun Park Hyunju Park Min Sun Choi Hye Won Jang Tae Hyuk Kim Sun Wook Kim Jae Hoon Chung
author_sort	Jinyoung Kim
title	Metastatic Lymph Node Ratio for Predicting Recurrence in Medullary Thyroid Cancer
title_short	Metastatic Lymph Node Ratio for Predicting Recurrence in Medullary Thyroid Cancer
title_full	Metastatic Lymph Node Ratio for Predicting Recurrence in Medullary Thyroid Cancer
title_fullStr	Metastatic Lymph Node Ratio for Predicting Recurrence in Medullary Thyroid Cancer
title_full_unstemmed	Metastatic Lymph Node Ratio for Predicting Recurrence in Medullary Thyroid Cancer
title_sort	metastatic lymph node ratio for predicting recurrence in medullary thyroid cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1a1f239554f24959925ee599aeb9d6bc
work_keys_str_mv	AT jinyoungkim metastaticlymphnoderatioforpredictingrecurrenceinmedullarythyroidcancer AT junpark metastaticlymphnoderatioforpredictingrecurrenceinmedullarythyroidcancer AT hyunjupark metastaticlymphnoderatioforpredictingrecurrenceinmedullarythyroidcancer AT minsunchoi metastaticlymphnoderatioforpredictingrecurrenceinmedullarythyroidcancer AT hyewonjang metastaticlymphnoderatioforpredictingrecurrenceinmedullarythyroidcancer AT taehyukkim metastaticlymphnoderatioforpredictingrecurrenceinmedullarythyroidcancer AT sunwookkim metastaticlymphnoderatioforpredictingrecurrenceinmedullarythyroidcancer AT jaehoonchung metastaticlymphnoderatioforpredictingrecurrenceinmedullarythyroidcancer
_version_	1718412698086014976

Metastatic Lymph Node Ratio for Predicting Recurrence in Medullary Thyroid Cancer

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