Closed-Loop Recycling Dual-Mode Counter-Current Chromatography with Specified Sample Loading Durations: Modeling of Preparative and Industrial-Scale Separations

We previously reported on a new counter-current chromatography (CCC) operating mode called closed-loop recycling dual-mode counter-current chromatography (CLR DM CCC), which incorporates the advantages of closed-loop recycling (CLR) and dual-mode (DM) counter-current chromatography and includes sequ...

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Autores principales:	Artak E. Kostanyan, Andrey A. Voshkin
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	closed-loop recycling chromatography dual-mode counter-current chromatography model-based design separation of complex mixtures with widely different partition coefficients Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/1a2126b3b6534a1c8c59c93feaf8bfed
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spelling	oai:doaj.org-article:1a2126b3b6534a1c8c59c93feaf8bfed2021-11-11T18:32:43ZClosed-Loop Recycling Dual-Mode Counter-Current Chromatography with Specified Sample Loading Durations: Modeling of Preparative and Industrial-Scale Separations10.3390/molecules262165611420-3049https://doaj.org/article/1a2126b3b6534a1c8c59c93feaf8bfed2021-10-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/21/6561https://doaj.org/toc/1420-3049We previously reported on a new counter-current chromatography (CCC) operating mode called closed-loop recycling dual-mode counter-current chromatography (CLR DM CCC), which incorporates the advantages of closed-loop recycling (CLR) and dual-mode (DM) counter-current chromatography and includes sequential separation of compounds in the closed-loop recycling mode with the mobile <i>x</i>-phase and in the inverted-phase counter-current mode with the mobile <i>y</i>-phase. The theoretical analysis of several implementations of this separation method was carried out under impulse sample injection conditions. This study is dedicated to the further development of CLR DM CCC theory applied to preparative and industrial separations, where high-throughput operation is required. Large sample volumes can be loaded via continuous loading within a specified time. To simulate CLR DM CCC separations with specified sample loading durations, equations are developed and presented in “Mathcad” software.Artak E. KostanyanAndrey A. VoshkinMDPI AGarticleclosed-loop recycling chromatographydual-mode counter-current chromatographymodel-based designseparation of complex mixtures with widely different partition coefficientsOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6561, p 6561 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	closed-loop recycling chromatography dual-mode counter-current chromatography model-based design separation of complex mixtures with widely different partition coefficients Organic chemistry QD241-441
spellingShingle	closed-loop recycling chromatography dual-mode counter-current chromatography model-based design separation of complex mixtures with widely different partition coefficients Organic chemistry QD241-441 Artak E. Kostanyan Andrey A. Voshkin Closed-Loop Recycling Dual-Mode Counter-Current Chromatography with Specified Sample Loading Durations: Modeling of Preparative and Industrial-Scale Separations
description	We previously reported on a new counter-current chromatography (CCC) operating mode called closed-loop recycling dual-mode counter-current chromatography (CLR DM CCC), which incorporates the advantages of closed-loop recycling (CLR) and dual-mode (DM) counter-current chromatography and includes sequential separation of compounds in the closed-loop recycling mode with the mobile <i>x</i>-phase and in the inverted-phase counter-current mode with the mobile <i>y</i>-phase. The theoretical analysis of several implementations of this separation method was carried out under impulse sample injection conditions. This study is dedicated to the further development of CLR DM CCC theory applied to preparative and industrial separations, where high-throughput operation is required. Large sample volumes can be loaded via continuous loading within a specified time. To simulate CLR DM CCC separations with specified sample loading durations, equations are developed and presented in “Mathcad” software.
format	article
author	Artak E. Kostanyan Andrey A. Voshkin
author_facet	Artak E. Kostanyan Andrey A. Voshkin
author_sort	Artak E. Kostanyan
title	Closed-Loop Recycling Dual-Mode Counter-Current Chromatography with Specified Sample Loading Durations: Modeling of Preparative and Industrial-Scale Separations
title_short	Closed-Loop Recycling Dual-Mode Counter-Current Chromatography with Specified Sample Loading Durations: Modeling of Preparative and Industrial-Scale Separations
title_full	Closed-Loop Recycling Dual-Mode Counter-Current Chromatography with Specified Sample Loading Durations: Modeling of Preparative and Industrial-Scale Separations
title_fullStr	Closed-Loop Recycling Dual-Mode Counter-Current Chromatography with Specified Sample Loading Durations: Modeling of Preparative and Industrial-Scale Separations
title_full_unstemmed	Closed-Loop Recycling Dual-Mode Counter-Current Chromatography with Specified Sample Loading Durations: Modeling of Preparative and Industrial-Scale Separations
title_sort	closed-loop recycling dual-mode counter-current chromatography with specified sample loading durations: modeling of preparative and industrial-scale separations
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1a2126b3b6534a1c8c59c93feaf8bfed
work_keys_str_mv	AT artakekostanyan closedlooprecyclingdualmodecountercurrentchromatographywithspecifiedsampleloadingdurationsmodelingofpreparativeandindustrialscaleseparations AT andreyavoshkin closedlooprecyclingdualmodecountercurrentchromatographywithspecifiedsampleloadingdurationsmodelingofpreparativeandindustrialscaleseparations
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Closed-Loop Recycling Dual-Mode Counter-Current Chromatography with Specified Sample Loading Durations: Modeling of Preparative and Industrial-Scale Separations

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