Association between Mycobacterium tuberculosis complex phylogenetic lineage and acquired drug resistance.

<h4>Background</h4>Development of resistance to antituberculosis drugs during treatment (i.e., acquired resistance) can lead to emergence of resistant strains and consequent poor clinical outcomes. However, it is unknown whether Mycobacterium tuberculosis complex species and lineage affe...

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Autores principales:	Courtney M Yuen, Ekaterina V Kurbatova, Eleanor S Click, J Sean Cavanaugh, J Peter Cegielski
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1a22faf0fe904398981757d91e3d2731
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spelling	oai:doaj.org-article:1a22faf0fe904398981757d91e3d27312021-11-18T08:40:40ZAssociation between Mycobacterium tuberculosis complex phylogenetic lineage and acquired drug resistance.1932-620310.1371/journal.pone.0083006https://doaj.org/article/1a22faf0fe904398981757d91e3d27312013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24376623/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Development of resistance to antituberculosis drugs during treatment (i.e., acquired resistance) can lead to emergence of resistant strains and consequent poor clinical outcomes. However, it is unknown whether Mycobacterium tuberculosis complex species and lineage affects the likelihood of acquired resistance.<h4>Methods</h4>We analyzed data from the U.S. National Tuberculosis Surveillance System and National Tuberculosis Genotyping Service for tuberculosis cases during 2004-2011 with assigned species and lineage and both initial and final drug susceptibility test results. We determined univariate associations between species and lineage of Mycobacterium tuberculosis complex bacteria and acquired resistance to isoniazid, rifamycins, fluoroquinolones, and second-line injectables. We used Poisson regression with backward elimination to generate multivariable models for acquired resistance to isoniazid and rifamycins.<h4>Results</h4>M. bovis was independently associated with acquired resistance to isoniazid (adjusted prevalence ratio = 8.46, 95% CI 2.96-24.14) adjusting for HIV status, and with acquired resistance to rifamycins (adjusted prevalence ratio = 4.53, 95% CI 1.29-15.90) adjusting for homelessness, HIV status, initial resistance to isoniazid, site of disease, and administration of therapy. East Asian lineage was associated with acquired resistance to fluoroquinolones (prevalence ratio = 6.10, 95% CI 1.56-23.83).<h4>Conclusions</h4>We found an association between mycobacterial species and lineage and acquired drug resistance using U.S. surveillance data. Prospective clinical studies are needed to determine the clinical significance of these findings, including whether rapid genotyping of isolates at the outset of treatment may benefit patient management.Courtney M YuenEkaterina V KurbatovaEleanor S ClickJ Sean CavanaughJ Peter CegielskiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e83006 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Courtney M Yuen Ekaterina V Kurbatova Eleanor S Click J Sean Cavanaugh J Peter Cegielski Association between Mycobacterium tuberculosis complex phylogenetic lineage and acquired drug resistance.
description	<h4>Background</h4>Development of resistance to antituberculosis drugs during treatment (i.e., acquired resistance) can lead to emergence of resistant strains and consequent poor clinical outcomes. However, it is unknown whether Mycobacterium tuberculosis complex species and lineage affects the likelihood of acquired resistance.<h4>Methods</h4>We analyzed data from the U.S. National Tuberculosis Surveillance System and National Tuberculosis Genotyping Service for tuberculosis cases during 2004-2011 with assigned species and lineage and both initial and final drug susceptibility test results. We determined univariate associations between species and lineage of Mycobacterium tuberculosis complex bacteria and acquired resistance to isoniazid, rifamycins, fluoroquinolones, and second-line injectables. We used Poisson regression with backward elimination to generate multivariable models for acquired resistance to isoniazid and rifamycins.<h4>Results</h4>M. bovis was independently associated with acquired resistance to isoniazid (adjusted prevalence ratio = 8.46, 95% CI 2.96-24.14) adjusting for HIV status, and with acquired resistance to rifamycins (adjusted prevalence ratio = 4.53, 95% CI 1.29-15.90) adjusting for homelessness, HIV status, initial resistance to isoniazid, site of disease, and administration of therapy. East Asian lineage was associated with acquired resistance to fluoroquinolones (prevalence ratio = 6.10, 95% CI 1.56-23.83).<h4>Conclusions</h4>We found an association between mycobacterial species and lineage and acquired drug resistance using U.S. surveillance data. Prospective clinical studies are needed to determine the clinical significance of these findings, including whether rapid genotyping of isolates at the outset of treatment may benefit patient management.
format	article
author	Courtney M Yuen Ekaterina V Kurbatova Eleanor S Click J Sean Cavanaugh J Peter Cegielski
author_facet	Courtney M Yuen Ekaterina V Kurbatova Eleanor S Click J Sean Cavanaugh J Peter Cegielski
author_sort	Courtney M Yuen
title	Association between Mycobacterium tuberculosis complex phylogenetic lineage and acquired drug resistance.
title_short	Association between Mycobacterium tuberculosis complex phylogenetic lineage and acquired drug resistance.
title_full	Association between Mycobacterium tuberculosis complex phylogenetic lineage and acquired drug resistance.
title_fullStr	Association between Mycobacterium tuberculosis complex phylogenetic lineage and acquired drug resistance.
title_full_unstemmed	Association between Mycobacterium tuberculosis complex phylogenetic lineage and acquired drug resistance.
title_sort	association between mycobacterium tuberculosis complex phylogenetic lineage and acquired drug resistance.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/1a22faf0fe904398981757d91e3d2731
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Association between Mycobacterium tuberculosis complex phylogenetic lineage and acquired drug resistance.

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