The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases

RNA and DNA polymerases need to discriminate efficiently against closely related nucleotide triphosphate substrates. Here, the authors show that a conserved Arg residue is the major determinant of selectivity against deoxyribonucleoside substrates by multisubunit RNA polymerases.

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Autores principales: Janne J. Mäkinen, Yeonoh Shin, Eeva Vieras, Pasi Virta, Mikko Metsä-Ketelä, Katsuhiko S. Murakami, Georgiy A. Belogurov
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/1a267789452f415e8760bfc2fe901636
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spelling oai:doaj.org-article:1a267789452f415e8760bfc2fe9016362021-12-02T14:06:23ZThe mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases10.1038/s41467-021-21005-w2041-1723https://doaj.org/article/1a267789452f415e8760bfc2fe9016362021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21005-whttps://doaj.org/toc/2041-1723RNA and DNA polymerases need to discriminate efficiently against closely related nucleotide triphosphate substrates. Here, the authors show that a conserved Arg residue is the major determinant of selectivity against deoxyribonucleoside substrates by multisubunit RNA polymerases.Janne J. MäkinenYeonoh ShinEeva VierasPasi VirtaMikko Metsä-KeteläKatsuhiko S. MurakamiGeorgiy A. BelogurovNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Janne J. Mäkinen
Yeonoh Shin
Eeva Vieras
Pasi Virta
Mikko Metsä-Ketelä
Katsuhiko S. Murakami
Georgiy A. Belogurov
The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases
description RNA and DNA polymerases need to discriminate efficiently against closely related nucleotide triphosphate substrates. Here, the authors show that a conserved Arg residue is the major determinant of selectivity against deoxyribonucleoside substrates by multisubunit RNA polymerases.
format article
author Janne J. Mäkinen
Yeonoh Shin
Eeva Vieras
Pasi Virta
Mikko Metsä-Ketelä
Katsuhiko S. Murakami
Georgiy A. Belogurov
author_facet Janne J. Mäkinen
Yeonoh Shin
Eeva Vieras
Pasi Virta
Mikko Metsä-Ketelä
Katsuhiko S. Murakami
Georgiy A. Belogurov
author_sort Janne J. Mäkinen
title The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases
title_short The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases
title_full The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases
title_fullStr The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases
title_full_unstemmed The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases
title_sort mechanism of the nucleo-sugar selection by multi-subunit rna polymerases
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/1a267789452f415e8760bfc2fe901636
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