The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases
RNA and DNA polymerases need to discriminate efficiently against closely related nucleotide triphosphate substrates. Here, the authors show that a conserved Arg residue is the major determinant of selectivity against deoxyribonucleoside substrates by multisubunit RNA polymerases.
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Nature Portfolio
2021
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oai:doaj.org-article:1a267789452f415e8760bfc2fe9016362021-12-02T14:06:23ZThe mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases10.1038/s41467-021-21005-w2041-1723https://doaj.org/article/1a267789452f415e8760bfc2fe9016362021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21005-whttps://doaj.org/toc/2041-1723RNA and DNA polymerases need to discriminate efficiently against closely related nucleotide triphosphate substrates. Here, the authors show that a conserved Arg residue is the major determinant of selectivity against deoxyribonucleoside substrates by multisubunit RNA polymerases.Janne J. MäkinenYeonoh ShinEeva VierasPasi VirtaMikko Metsä-KeteläKatsuhiko S. MurakamiGeorgiy A. BelogurovNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021) |
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Science Q Janne J. Mäkinen Yeonoh Shin Eeva Vieras Pasi Virta Mikko Metsä-Ketelä Katsuhiko S. Murakami Georgiy A. Belogurov The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases |
description |
RNA and DNA polymerases need to discriminate efficiently against closely related nucleotide triphosphate substrates. Here, the authors show that a conserved Arg residue is the major determinant of selectivity against deoxyribonucleoside substrates by multisubunit RNA polymerases. |
format |
article |
author |
Janne J. Mäkinen Yeonoh Shin Eeva Vieras Pasi Virta Mikko Metsä-Ketelä Katsuhiko S. Murakami Georgiy A. Belogurov |
author_facet |
Janne J. Mäkinen Yeonoh Shin Eeva Vieras Pasi Virta Mikko Metsä-Ketelä Katsuhiko S. Murakami Georgiy A. Belogurov |
author_sort |
Janne J. Mäkinen |
title |
The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases |
title_short |
The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases |
title_full |
The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases |
title_fullStr |
The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases |
title_full_unstemmed |
The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases |
title_sort |
mechanism of the nucleo-sugar selection by multi-subunit rna polymerases |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/1a267789452f415e8760bfc2fe901636 |
work_keys_str_mv |
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