The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases
RNA and DNA polymerases need to discriminate efficiently against closely related nucleotide triphosphate substrates. Here, the authors show that a conserved Arg residue is the major determinant of selectivity against deoxyribonucleoside substrates by multisubunit RNA polymerases.
Guardado en:
Autores principales: | Janne J. Mäkinen, Yeonoh Shin, Eeva Vieras, Pasi Virta, Mikko Metsä-Ketelä, Katsuhiko S. Murakami, Georgiy A. Belogurov |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/1a267789452f415e8760bfc2fe901636 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
The δ subunit and NTPase HelD institute a two-pronged mechanism for RNA polymerase recycling
por: Hao-Hong Pei, et al.
Publicado: (2020) -
Single-peptide DNA-dependent RNA polymerase homologous to multi-subunit RNA polymerase
por: David Forrest, et al.
Publicado: (2017) -
A distinct lineage of Caudovirales that encodes a deeply branching multi-subunit RNA polymerase
por: Alaina R. Weinheimer, et al.
Publicado: (2020) -
P50, the small subunit of DNA polymerase delta, is required for mediation of the interaction of polymerase delta subassemblies with PCNA.
por: Yujue Wang, et al.
Publicado: (2011) -
Shared active site architecture between archaeal PolD and multi-subunit RNA polymerases revealed by X-ray crystallography
por: Ludovic Sauguet, et al.
Publicado: (2016)