Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells

Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells

Wnt ligands are essential for intestinal homoeostasis and stem cell maintenance. Here, the authors show that reduction in Wnt secretion reduces the number of intestinal stem cells; this results in rapid fixation of mutated stem cells and accelerated adenoma formation due to lack of cell competition.

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Autores principales: D. J. Huels, L. Bruens, M. C. Hodder, P. Cammareri, A. D. Campbell, R. A. Ridgway, D. M. Gay, M. Solar-Abboud, W. J. Faller, C. Nixon, L. B. Zeiger, M. E. McLaughlin, E. Morrissey, D. J. Winton, H. J. Snippert, J. van Rheenen, O. J. Sansom
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Q
Acceso en línea:https://doaj.org/article/1a2839335a8e4193bb5d85dedd7c98ab
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spelling oai:doaj.org-article:1a2839335a8e4193bb5d85dedd7c98ab2021-12-02T16:49:39ZWnt ligands influence tumour initiation by controlling the number of intestinal stem cells10.1038/s41467-018-03426-22041-1723https://doaj.org/article/1a2839335a8e4193bb5d85dedd7c98ab2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03426-2https://doaj.org/toc/2041-1723Wnt ligands are essential for intestinal homoeostasis and stem cell maintenance. Here, the authors show that reduction in Wnt secretion reduces the number of intestinal stem cells; this results in rapid fixation of mutated stem cells and accelerated adenoma formation due to lack of cell competition.D. J. HuelsL. BruensM. C. HodderP. CammareriA. D. CampbellR. A. RidgwayD. M. GayM. Solar-AbboudW. J. FallerC. NixonL. B. ZeigerM. E. McLaughlinE. MorrisseyD. J. WintonH. J. SnippertJ. van RheenenO. J. SansomNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
D. J. Huels
L. Bruens
M. C. Hodder
P. Cammareri
A. D. Campbell
R. A. Ridgway
D. M. Gay
M. Solar-Abboud
W. J. Faller
C. Nixon
L. B. Zeiger
M. E. McLaughlin
E. Morrissey
D. J. Winton
H. J. Snippert
J. van Rheenen
O. J. Sansom
Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells
description Wnt ligands are essential for intestinal homoeostasis and stem cell maintenance. Here, the authors show that reduction in Wnt secretion reduces the number of intestinal stem cells; this results in rapid fixation of mutated stem cells and accelerated adenoma formation due to lack of cell competition.
format article
author D. J. Huels
L. Bruens
M. C. Hodder
P. Cammareri
A. D. Campbell
R. A. Ridgway
D. M. Gay
M. Solar-Abboud
W. J. Faller
C. Nixon
L. B. Zeiger
M. E. McLaughlin
E. Morrissey
D. J. Winton
H. J. Snippert
J. van Rheenen
O. J. Sansom
author_facet D. J. Huels
L. Bruens
M. C. Hodder
P. Cammareri
A. D. Campbell
R. A. Ridgway
D. M. Gay
M. Solar-Abboud
W. J. Faller
C. Nixon
L. B. Zeiger
M. E. McLaughlin
E. Morrissey
D. J. Winton
H. J. Snippert
J. van Rheenen
O. J. Sansom
author_sort D. J. Huels
title Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells
title_short Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells
title_full Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells
title_fullStr Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells
title_full_unstemmed Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells
title_sort wnt ligands influence tumour initiation by controlling the number of intestinal stem cells
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/1a2839335a8e4193bb5d85dedd7c98ab
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