APPARENT MOLAR VOLUMES OF THE ΒETA-ADRENERGIC BLOCKER PROPRANOLOL-HCl IN AQUEOUS MEDIA AT SEVERAL TEMPERATURES

Propranolol-HCl is a non selective β-adrenergic blocker widely used in the treatment of several cardiovascular diseases; nevertheless, the physicochemical information about its volumetric behavior and other aqueous properties is not complete at present. In this context, densities of aqueous solution...

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Autores principales:	Daniel Ricardo DELGADO, Edgar Francisco VARGAS, Fleming MARTÍNEZ
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2011
Materias:	Propranolol apparent molar volume molar expansibility dissolution chemical thermodynamics Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/1a2a16e8922449b789f5faaf5bb1f12d
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spelling	oai:doaj.org-article:1a2a16e8922449b789f5faaf5bb1f12d2021-11-19T04:14:05ZAPPARENT MOLAR VOLUMES OF THE ΒETA-ADRENERGIC BLOCKER PROPRANOLOL-HCl IN AQUEOUS MEDIA AT SEVERAL TEMPERATURES0121-40042145-2660https://doaj.org/article/1a2a16e8922449b789f5faaf5bb1f12d2011-05-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/8779https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660Propranolol-HCl is a non selective β-adrenergic blocker widely used in the treatment of several cardiovascular diseases; nevertheless, the physicochemical information about its volumetric behavior and other aqueous properties is not complete at present. In this context, densities of aqueous solutions of propanolol-HCl have been measured in this research as a function of concentration (from 0.0500 to 0.2500) mol kg–1 at several temperatures, i.e. (278.15, 283.15, 288.15, 293.15, 298.15, 303.15, 308.15 and 313.15) K. These values have not been reported earlier in the literature. The apparent molar volumes and partial molar volumes at infinite dilution for the electrolyte drug were calculated. Otherwise, the partial molar volumes at infinite dilution and the partial molar expansibilities for the drug as molecular form were also calculated. The dependence of these properties on temperature is presented. The results are interpreted in terms of several solute-solvent interactions. Ultimately, the reported information can be useful to understand the intermolecular events exhibited by this drug in pharmaceutical and biological systems.Daniel Ricardo DELGADOEdgar Francisco VARGASFleming MARTÍNEZUniversidad de AntioquiaarticlePropranololapparent molar volumemolar expansibilitydissolutionchemical thermodynamicsFood processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 18, Iss 1 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Propranolol apparent molar volume molar expansibility dissolution chemical thermodynamics Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	Propranolol apparent molar volume molar expansibility dissolution chemical thermodynamics Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Daniel Ricardo DELGADO Edgar Francisco VARGAS Fleming MARTÍNEZ APPARENT MOLAR VOLUMES OF THE ΒETA-ADRENERGIC BLOCKER PROPRANOLOL-HCl IN AQUEOUS MEDIA AT SEVERAL TEMPERATURES
description	Propranolol-HCl is a non selective β-adrenergic blocker widely used in the treatment of several cardiovascular diseases; nevertheless, the physicochemical information about its volumetric behavior and other aqueous properties is not complete at present. In this context, densities of aqueous solutions of propanolol-HCl have been measured in this research as a function of concentration (from 0.0500 to 0.2500) mol kg–1 at several temperatures, i.e. (278.15, 283.15, 288.15, 293.15, 298.15, 303.15, 308.15 and 313.15) K. These values have not been reported earlier in the literature. The apparent molar volumes and partial molar volumes at infinite dilution for the electrolyte drug were calculated. Otherwise, the partial molar volumes at infinite dilution and the partial molar expansibilities for the drug as molecular form were also calculated. The dependence of these properties on temperature is presented. The results are interpreted in terms of several solute-solvent interactions. Ultimately, the reported information can be useful to understand the intermolecular events exhibited by this drug in pharmaceutical and biological systems.
format	article
author	Daniel Ricardo DELGADO Edgar Francisco VARGAS Fleming MARTÍNEZ
author_facet	Daniel Ricardo DELGADO Edgar Francisco VARGAS Fleming MARTÍNEZ
author_sort	Daniel Ricardo DELGADO
title	APPARENT MOLAR VOLUMES OF THE ΒETA-ADRENERGIC BLOCKER PROPRANOLOL-HCl IN AQUEOUS MEDIA AT SEVERAL TEMPERATURES
title_short	APPARENT MOLAR VOLUMES OF THE ΒETA-ADRENERGIC BLOCKER PROPRANOLOL-HCl IN AQUEOUS MEDIA AT SEVERAL TEMPERATURES
title_full	APPARENT MOLAR VOLUMES OF THE ΒETA-ADRENERGIC BLOCKER PROPRANOLOL-HCl IN AQUEOUS MEDIA AT SEVERAL TEMPERATURES
title_fullStr	APPARENT MOLAR VOLUMES OF THE ΒETA-ADRENERGIC BLOCKER PROPRANOLOL-HCl IN AQUEOUS MEDIA AT SEVERAL TEMPERATURES
title_full_unstemmed	APPARENT MOLAR VOLUMES OF THE ΒETA-ADRENERGIC BLOCKER PROPRANOLOL-HCl IN AQUEOUS MEDIA AT SEVERAL TEMPERATURES
title_sort	apparent molar volumes of the βeta-adrenergic blocker propranolol-hcl in aqueous media at several temperatures
publisher	Universidad de Antioquia
publishDate	2011
url	https://doaj.org/article/1a2a16e8922449b789f5faaf5bb1f12d
work_keys_str_mv	AT danielricardodelgado apparentmolarvolumesofthebetaadrenergicblockerpropranololhclinaqueousmediaatseveraltemperatures AT edgarfranciscovargas apparentmolarvolumesofthebetaadrenergicblockerpropranololhclinaqueousmediaatseveraltemperatures AT flemingmartinez apparentmolarvolumesofthebetaadrenergicblockerpropranololhclinaqueousmediaatseveraltemperatures
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APPARENT MOLAR VOLUMES OF THE ΒETA-ADRENERGIC BLOCKER PROPRANOLOL-HCl IN AQUEOUS MEDIA AT SEVERAL TEMPERATURES

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