Structural basis of RNA cap modification by SARS-CoV-2
Specific non-structural proteins (nsp) of SARS coronaviruses are involved in methylation of virally encoded mRNAs to mimic cellular mRNAs for protection against host innate immune restriction. Here, the authors present a high resolution structure of SARS-CoV-2 nsp16/nsp10 ternary complex in the pres...
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Nature Portfolio
2020
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oai:doaj.org-article:1a2c5dcfc62842e8b013e549e88fbd222021-12-02T16:17:53ZStructural basis of RNA cap modification by SARS-CoV-210.1038/s41467-020-17496-82041-1723https://doaj.org/article/1a2c5dcfc62842e8b013e549e88fbd222020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17496-8https://doaj.org/toc/2041-1723Specific non-structural proteins (nsp) of SARS coronaviruses are involved in methylation of virally encoded mRNAs to mimic cellular mRNAs for protection against host innate immune restriction. Here, the authors present a high resolution structure of SARS-CoV-2 nsp16/nsp10 ternary complex in the presence of cognate RNA substrate analogue and methyl donor, S-adenosyl methionine, revealing unique ligand-binding sites that may represent alternative targets for antiviral development.Thiruselvam ViswanathanShailee AryaSiu-Hong ChanShan QiNan DaiAnurag MisraJun-Gyu ParkFatai OladunniDmytro KovalskyyRobert A. HromasLuis Martinez-SobridoYogesh K. GuptaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-7 (2020) |
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Science Q Thiruselvam Viswanathan Shailee Arya Siu-Hong Chan Shan Qi Nan Dai Anurag Misra Jun-Gyu Park Fatai Oladunni Dmytro Kovalskyy Robert A. Hromas Luis Martinez-Sobrido Yogesh K. Gupta Structural basis of RNA cap modification by SARS-CoV-2 |
description |
Specific non-structural proteins (nsp) of SARS coronaviruses are involved in methylation of virally encoded mRNAs to mimic cellular mRNAs for protection against host innate immune restriction. Here, the authors present a high resolution structure of SARS-CoV-2 nsp16/nsp10 ternary complex in the presence of cognate RNA substrate analogue and methyl donor, S-adenosyl methionine, revealing unique ligand-binding sites that may represent alternative targets for antiviral development. |
format |
article |
author |
Thiruselvam Viswanathan Shailee Arya Siu-Hong Chan Shan Qi Nan Dai Anurag Misra Jun-Gyu Park Fatai Oladunni Dmytro Kovalskyy Robert A. Hromas Luis Martinez-Sobrido Yogesh K. Gupta |
author_facet |
Thiruselvam Viswanathan Shailee Arya Siu-Hong Chan Shan Qi Nan Dai Anurag Misra Jun-Gyu Park Fatai Oladunni Dmytro Kovalskyy Robert A. Hromas Luis Martinez-Sobrido Yogesh K. Gupta |
author_sort |
Thiruselvam Viswanathan |
title |
Structural basis of RNA cap modification by SARS-CoV-2 |
title_short |
Structural basis of RNA cap modification by SARS-CoV-2 |
title_full |
Structural basis of RNA cap modification by SARS-CoV-2 |
title_fullStr |
Structural basis of RNA cap modification by SARS-CoV-2 |
title_full_unstemmed |
Structural basis of RNA cap modification by SARS-CoV-2 |
title_sort |
structural basis of rna cap modification by sars-cov-2 |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/1a2c5dcfc62842e8b013e549e88fbd22 |
work_keys_str_mv |
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1718384217108250624 |