Mortality due to COVID-19 infection: A comparison of first and second waves

Background The USA suffered an initial wave of COVID-19 cases from March to July in 2020. Cases again surged in August 2020 as business restrictions were lifted. We aimed to describe demographic, treatment, and mortality differences between both waves. Methods We identified all hospitalized patients...

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Autores principales:	Olubunmi Oladunjoye, Molly Gallagher, Tom Wasser, Adeolu Oladunjoye, Susmita Paladugu, Anthony Donato
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	covid-19 mortality hospitalization pandemic; sars-cov-2 Internal medicine RC31-1245
Acceso en línea:	https://doaj.org/article/1a2f10b6869b46d2934f20c901b54192
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spelling	oai:doaj.org-article:1a2f10b6869b46d2934f20c901b541922021-11-17T14:21:57ZMortality due to COVID-19 infection: A comparison of first and second waves2000-966610.1080/20009666.2021.1978154https://doaj.org/article/1a2f10b6869b46d2934f20c901b541922021-11-01T00:00:00Zhttp://dx.doi.org/10.1080/20009666.2021.1978154https://doaj.org/toc/2000-9666Background The USA suffered an initial wave of COVID-19 cases from March to July in 2020. Cases again surged in August 2020 as business restrictions were lifted. We aimed to describe demographic, treatment, and mortality differences between both waves. Methods We identified all hospitalized patients with COVID-19 infection in one US six-hospital health system between 1 March 2020 and 31 January 2021. We compared data obtained on patient demographics, treatment received, and mortality between first and second waves of the pandemic. Results A total of 4434 hospitalized COVID patients were identified, including 1313 patients in the first wave and 3121 patients in the second wave. Mortality was significantly higher in the first wave as compared to the second wave (23.2% vs. 12.3%, p < 0.001). Age and sex were similar in each wave. In the first wave, there were significantly more Non-Hispanic Black patients (28.8 vs. 18.1%, p < 0.001) and Hispanic patients (26.6% vs. 14.9%, p < 0.001) as compared to the second wave. There was a higher mortality rate in the first wave as compared to the second, which persisted after multivariable adjustment for sex, age, ethnicity, laboratory results at admission, treatment received, high flow use and mechanical ventilation (OR: 2.66, 95% CI: 1.83–3.87, p < 0.001). Conclusion Mortality in the second wave was lower than the first wave with significantly higher utilization of steroids, remdesivir and convalescent plasma in second wave.Olubunmi OladunjoyeMolly GallagherTom WasserAdeolu OladunjoyeSusmita PaladuguAnthony DonatoTaylor & Francis Grouparticlecovid-19mortalityhospitalizationpandemic; sars-cov-2Internal medicineRC31-1245ENJournal of Community Hospital Internal Medicine Perspectives, Vol 11, Iss 6, Pp 747-752 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	covid-19 mortality hospitalization pandemic; sars-cov-2 Internal medicine RC31-1245
spellingShingle	covid-19 mortality hospitalization pandemic; sars-cov-2 Internal medicine RC31-1245 Olubunmi Oladunjoye Molly Gallagher Tom Wasser Adeolu Oladunjoye Susmita Paladugu Anthony Donato Mortality due to COVID-19 infection: A comparison of first and second waves
description	Background The USA suffered an initial wave of COVID-19 cases from March to July in 2020. Cases again surged in August 2020 as business restrictions were lifted. We aimed to describe demographic, treatment, and mortality differences between both waves. Methods We identified all hospitalized patients with COVID-19 infection in one US six-hospital health system between 1 March 2020 and 31 January 2021. We compared data obtained on patient demographics, treatment received, and mortality between first and second waves of the pandemic. Results A total of 4434 hospitalized COVID patients were identified, including 1313 patients in the first wave and 3121 patients in the second wave. Mortality was significantly higher in the first wave as compared to the second wave (23.2% vs. 12.3%, p < 0.001). Age and sex were similar in each wave. In the first wave, there were significantly more Non-Hispanic Black patients (28.8 vs. 18.1%, p < 0.001) and Hispanic patients (26.6% vs. 14.9%, p < 0.001) as compared to the second wave. There was a higher mortality rate in the first wave as compared to the second, which persisted after multivariable adjustment for sex, age, ethnicity, laboratory results at admission, treatment received, high flow use and mechanical ventilation (OR: 2.66, 95% CI: 1.83–3.87, p < 0.001). Conclusion Mortality in the second wave was lower than the first wave with significantly higher utilization of steroids, remdesivir and convalescent plasma in second wave.
format	article
author	Olubunmi Oladunjoye Molly Gallagher Tom Wasser Adeolu Oladunjoye Susmita Paladugu Anthony Donato
author_facet	Olubunmi Oladunjoye Molly Gallagher Tom Wasser Adeolu Oladunjoye Susmita Paladugu Anthony Donato
author_sort	Olubunmi Oladunjoye
title	Mortality due to COVID-19 infection: A comparison of first and second waves
title_short	Mortality due to COVID-19 infection: A comparison of first and second waves
title_full	Mortality due to COVID-19 infection: A comparison of first and second waves
title_fullStr	Mortality due to COVID-19 infection: A comparison of first and second waves
title_full_unstemmed	Mortality due to COVID-19 infection: A comparison of first and second waves
title_sort	mortality due to covid-19 infection: a comparison of first and second waves
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/1a2f10b6869b46d2934f20c901b54192
work_keys_str_mv	AT olubunmioladunjoye mortalityduetocovid19infectionacomparisonoffirstandsecondwaves AT mollygallagher mortalityduetocovid19infectionacomparisonoffirstandsecondwaves AT tomwasser mortalityduetocovid19infectionacomparisonoffirstandsecondwaves AT adeoluoladunjoye mortalityduetocovid19infectionacomparisonoffirstandsecondwaves AT susmitapaladugu mortalityduetocovid19infectionacomparisonoffirstandsecondwaves AT anthonydonato mortalityduetocovid19infectionacomparisonoffirstandsecondwaves
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Mortality due to COVID-19 infection: A comparison of first and second waves

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