Self-assembling surfactant-like peptide A6K as potential delivery system for hydrophobic drugs

Yongzhu Chen,1 Chengkang Tang,2 Jie Zhang,2 Meng Gong,3 Bo Su,2 Feng Qiu4 1Periodical Press, 2Core Facility of West China Hospital, 3Laboratory of Endocrinology and Metabolism, West China Hospital, 4Laboratory of Anaesthesia and Critical Care Medicine, Translational Neuroscience Centre, West China...

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Autores principales:	Chen Y, Tang C, Zhang J, Gong M, Su B, Qiu F
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1a325cb6800f4302a7de5e4ad90eccd9
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spelling	oai:doaj.org-article:1a325cb6800f4302a7de5e4ad90eccd92021-12-02T05:22:10ZSelf-assembling surfactant-like peptide A6K as potential delivery system for hydrophobic drugs1178-2013https://doaj.org/article/1a325cb6800f4302a7de5e4ad90eccd92015-01-01T00:00:00Zhttp://www.dovepress.com/self-assembling-surfactant-like-peptide-a6k-as-potential-delivery-syst-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013 Yongzhu Chen,1 Chengkang Tang,2 Jie Zhang,2 Meng Gong,3 Bo Su,2 Feng Qiu4 1Periodical Press, 2Core Facility of West China Hospital, 3Laboratory of Endocrinology and Metabolism, West China Hospital, 4Laboratory of Anaesthesia and Critical Care Medicine, Translational Neuroscience Centre, West China Hospital, Sichuan University, Chengdu, People’s Republic of China Background: Finding a suitable delivery system to improve the water solubility of hydrophobic drugs is a critical challenge in the development of effective formulations. In this study, we used A6K, a self-assembling surfactant-like peptide, as a carrier to encapsulate and deliver hydrophobic pyrene.Methods: Pyrene was mixed with A6K by magnetic stirring to form a suspension. Confocal laser scanning microscopy, transmission electron microscopy, dynamic light scattering, atomic force microscopy, fluorescence, and cell uptake measurements were carried out to study the features and stability of the nanostructures, the state and content of pyrene, as well as the pyrene release profile.Results: The suspension formed contained pyrene monomers trapped in the hydrophobic cores of the micellar nanofibers formed by A6K, as well as nanosized pyrene crystals wrapped up and stabilized by the nanofibers. The two different encapsulation methods greatly increased the concentration of pyrene in the suspension, and formation of pyrene crystals wrapped up by A6K nanofibers might be the major contributor to this effect. Furthermore, the suspension system could readily release and transfer pyrene into living cells.Conclusion: A6K could be further exploited as a promising delivery system for hydrophobic drugs. Keywords: pyrene, self-assembling peptide, micelles, nanofibers, drug delivery  Chen YTang CZhang JGong MSu BQiu FDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 847-858 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Chen Y Tang C Zhang J Gong M Su B Qiu F Self-assembling surfactant-like peptide A6K as potential delivery system for hydrophobic drugs
description	Yongzhu Chen,1 Chengkang Tang,2 Jie Zhang,2 Meng Gong,3 Bo Su,2 Feng Qiu4 1Periodical Press, 2Core Facility of West China Hospital, 3Laboratory of Endocrinology and Metabolism, West China Hospital, 4Laboratory of Anaesthesia and Critical Care Medicine, Translational Neuroscience Centre, West China Hospital, Sichuan University, Chengdu, People’s Republic of China Background: Finding a suitable delivery system to improve the water solubility of hydrophobic drugs is a critical challenge in the development of effective formulations. In this study, we used A6K, a self-assembling surfactant-like peptide, as a carrier to encapsulate and deliver hydrophobic pyrene.Methods: Pyrene was mixed with A6K by magnetic stirring to form a suspension. Confocal laser scanning microscopy, transmission electron microscopy, dynamic light scattering, atomic force microscopy, fluorescence, and cell uptake measurements were carried out to study the features and stability of the nanostructures, the state and content of pyrene, as well as the pyrene release profile.Results: The suspension formed contained pyrene monomers trapped in the hydrophobic cores of the micellar nanofibers formed by A6K, as well as nanosized pyrene crystals wrapped up and stabilized by the nanofibers. The two different encapsulation methods greatly increased the concentration of pyrene in the suspension, and formation of pyrene crystals wrapped up by A6K nanofibers might be the major contributor to this effect. Furthermore, the suspension system could readily release and transfer pyrene into living cells.Conclusion: A6K could be further exploited as a promising delivery system for hydrophobic drugs. Keywords: pyrene, self-assembling peptide, micelles, nanofibers, drug delivery
format	article
author	Chen Y Tang C Zhang J Gong M Su B Qiu F
author_facet	Chen Y Tang C Zhang J Gong M Su B Qiu F
author_sort	Chen Y
title	Self-assembling surfactant-like peptide A6K as potential delivery system for hydrophobic drugs
title_short	Self-assembling surfactant-like peptide A6K as potential delivery system for hydrophobic drugs
title_full	Self-assembling surfactant-like peptide A6K as potential delivery system for hydrophobic drugs
title_fullStr	Self-assembling surfactant-like peptide A6K as potential delivery system for hydrophobic drugs
title_full_unstemmed	Self-assembling surfactant-like peptide A6K as potential delivery system for hydrophobic drugs
title_sort	self-assembling surfactant-like peptide a6k as potential delivery system for hydrophobic drugs
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/1a325cb6800f4302a7de5e4ad90eccd9
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Self-assembling surfactant-like peptide A6K as potential delivery system for hydrophobic drugs

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