Mutations in <italic toggle="yes">hmg1</italic>, Challenging the Paradigm of Clinical Triazole Resistance in <named-content content-type="genus-species">Aspergillus fumigatus</named-content>

Mutations in <italic toggle="yes">hmg1</italic>, Challenging the Paradigm of Clinical Triazole Resistance in <named-content content-type="genus-species">Aspergillus fumigatus</named-content>

ABSTRACT Aspergillus fumigatus is the predominant pathogen of invasive aspergillosis, a disease state credited with over 200,000 life-threatening infections each year. The triazole class of antifungals are clinically essential to the treatment of invasive aspergillosis, both as frontline and as salv...

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Autores principales: Jeffrey M. Rybak, Wenbo Ge, Nathan P. Wiederhold, Josie E. Parker, Steven L. Kelly, P. David Rogers, Jarrod R. Fortwendel
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2019
Materias:
Aspergillus fumigatus
HMG-CoA reductase
antifungal resistance
ergosterol
hmg1
triazole
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/1a326c478b58433da1a49105ffc817db
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