Impaired olfactory neurogenesis affects the performance of olfactory-guided behavior in aged female opossums

Abstract Increasing evidence has indicated that adult neurogenesis contributes to brain plasticity, although function of new neurons is still under debate. In opossums, we performed an olfactory-guided behavior task and examined the association between olfactory discrimination-guided behavior and ad...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Beata Tepper, Paulina Koguc-Sobolewska, Katarzyna Jaslan, Krzysztof Turlejski, Katarzyna Bartkowska, Ruzanna Djavadian
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1a33916548bc4225ad35cfbaae515b07
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1a33916548bc4225ad35cfbaae515b07
record_format	dspace
spelling	oai:doaj.org-article:1a33916548bc4225ad35cfbaae515b072021-12-02T13:35:03ZImpaired olfactory neurogenesis affects the performance of olfactory-guided behavior in aged female opossums10.1038/s41598-021-83834-52045-2322https://doaj.org/article/1a33916548bc4225ad35cfbaae515b072021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83834-5https://doaj.org/toc/2045-2322Abstract Increasing evidence has indicated that adult neurogenesis contributes to brain plasticity, although function of new neurons is still under debate. In opossums, we performed an olfactory-guided behavior task and examined the association between olfactory discrimination-guided behavior and adult neurogenesis in the olfactory bulb (OB). We found that young and aged opossums of either sex learned to find food buried in litter using olfactory cues. However, aged females required more time to find food compared to aged males and young opossums of both sexes. The levels of doublecortin, that is used as a marker for immature neurons, were the lowest in the OB of aged female opossums. Another protein, HuD that is associated with learning and memory, was detected in all layers of the OB, except the granule cell layer, where a high density of DCX cells was detected. The level of HuD was higher in aged opossums compared to young opossums. This indicates that HuD is involved in plasticity and negatively regulates olfactory perception. The majority of 2-year-old female opossums are in the post-reproductive age but males of this age are still sexually active. We suggest that in aged female opossums neural plasticity induced by adult neurogenesis decreases due to their hormonal decline.Beata TepperPaulina Koguc-SobolewskaKatarzyna JaslanKrzysztof TurlejskiKatarzyna BartkowskaRuzanna DjavadianNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Beata Tepper Paulina Koguc-Sobolewska Katarzyna Jaslan Krzysztof Turlejski Katarzyna Bartkowska Ruzanna Djavadian Impaired olfactory neurogenesis affects the performance of olfactory-guided behavior in aged female opossums
description	Abstract Increasing evidence has indicated that adult neurogenesis contributes to brain plasticity, although function of new neurons is still under debate. In opossums, we performed an olfactory-guided behavior task and examined the association between olfactory discrimination-guided behavior and adult neurogenesis in the olfactory bulb (OB). We found that young and aged opossums of either sex learned to find food buried in litter using olfactory cues. However, aged females required more time to find food compared to aged males and young opossums of both sexes. The levels of doublecortin, that is used as a marker for immature neurons, were the lowest in the OB of aged female opossums. Another protein, HuD that is associated with learning and memory, was detected in all layers of the OB, except the granule cell layer, where a high density of DCX cells was detected. The level of HuD was higher in aged opossums compared to young opossums. This indicates that HuD is involved in plasticity and negatively regulates olfactory perception. The majority of 2-year-old female opossums are in the post-reproductive age but males of this age are still sexually active. We suggest that in aged female opossums neural plasticity induced by adult neurogenesis decreases due to their hormonal decline.
format	article
author	Beata Tepper Paulina Koguc-Sobolewska Katarzyna Jaslan Krzysztof Turlejski Katarzyna Bartkowska Ruzanna Djavadian
author_facet	Beata Tepper Paulina Koguc-Sobolewska Katarzyna Jaslan Krzysztof Turlejski Katarzyna Bartkowska Ruzanna Djavadian
author_sort	Beata Tepper
title	Impaired olfactory neurogenesis affects the performance of olfactory-guided behavior in aged female opossums
title_short	Impaired olfactory neurogenesis affects the performance of olfactory-guided behavior in aged female opossums
title_full	Impaired olfactory neurogenesis affects the performance of olfactory-guided behavior in aged female opossums
title_fullStr	Impaired olfactory neurogenesis affects the performance of olfactory-guided behavior in aged female opossums
title_full_unstemmed	Impaired olfactory neurogenesis affects the performance of olfactory-guided behavior in aged female opossums
title_sort	impaired olfactory neurogenesis affects the performance of olfactory-guided behavior in aged female opossums
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1a33916548bc4225ad35cfbaae515b07
work_keys_str_mv	AT beatatepper impairedolfactoryneurogenesisaffectstheperformanceofolfactoryguidedbehaviorinagedfemaleopossums AT paulinakogucsobolewska impairedolfactoryneurogenesisaffectstheperformanceofolfactoryguidedbehaviorinagedfemaleopossums AT katarzynajaslan impairedolfactoryneurogenesisaffectstheperformanceofolfactoryguidedbehaviorinagedfemaleopossums AT krzysztofturlejski impairedolfactoryneurogenesisaffectstheperformanceofolfactoryguidedbehaviorinagedfemaleopossums AT katarzynabartkowska impairedolfactoryneurogenesisaffectstheperformanceofolfactoryguidedbehaviorinagedfemaleopossums AT ruzannadjavadian impairedolfactoryneurogenesisaffectstheperformanceofolfactoryguidedbehaviorinagedfemaleopossums
_version_	1718392720237527040

Impaired olfactory neurogenesis affects the performance of olfactory-guided behavior in aged female opossums

Ejemplares similares