Intradiscal quantitative chemical exchange saturation transfer MRI signal correlates with discogenic pain in human patients
Abstract Low back pain (LBP) is often a result of a degenerative process in the intervertebral disc. The precise origin of discogenic pain is diagnosed by the invasive procedure of provocative discography (PD). Previously, we developed quantitative chemical exchange saturation transfer (qCEST) magne...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/1a3459a68fb84f2d89e23e8ca6981fe8 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:1a3459a68fb84f2d89e23e8ca6981fe8 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:1a3459a68fb84f2d89e23e8ca6981fe82021-12-02T17:17:40ZIntradiscal quantitative chemical exchange saturation transfer MRI signal correlates with discogenic pain in human patients10.1038/s41598-021-97672-y2045-2322https://doaj.org/article/1a3459a68fb84f2d89e23e8ca6981fe82021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97672-yhttps://doaj.org/toc/2045-2322Abstract Low back pain (LBP) is often a result of a degenerative process in the intervertebral disc. The precise origin of discogenic pain is diagnosed by the invasive procedure of provocative discography (PD). Previously, we developed quantitative chemical exchange saturation transfer (qCEST) magnetic resonance imaging (MRI) to detect pH as a biomarker for discogenic pain. Based on these findings we initiated a clinical study with the goal to evaluate the correlation between qCEST values and PD results in LBP patients. Twenty five volunteers with chronic low back pain were subjected to T2-weighted (T2w) and qCEST MRI scans followed by PD. A total of 72 discs were analyzed. The average qCEST signal value of painful discs was significantly higher than non-painful discs (p = 0.012). The ratio between qCEST and normalized T2w was found to be significantly higher in painful discs compared to non-painful discs (p = 0.0022). A receiver operating characteristics (ROC) analysis indicated that qCEST/T2w ratio could be used to differentiate between painful and non-painful discs with 78% sensitivity and 81% specificity. The results of the study suggest that qCEST could be used for the diagnosis of discogenic pain, in conjunction with the commonly used T2w scan.Gadi PelledMargaux M. SalasPei HanHoward E. GillKarl A. LautenschlagerTristan T. LaiCameron M. ShawverMatthew B. HochBrandon J. GoffAaron M. BettsZhengwei ZhouCody LynchGrant SchroederMaxim BezMarcel M. MayaCatherine BreseeZulma GazitJohn P. McCallinDan GazitDebiao LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Gadi Pelled Margaux M. Salas Pei Han Howard E. Gill Karl A. Lautenschlager Tristan T. Lai Cameron M. Shawver Matthew B. Hoch Brandon J. Goff Aaron M. Betts Zhengwei Zhou Cody Lynch Grant Schroeder Maxim Bez Marcel M. Maya Catherine Bresee Zulma Gazit John P. McCallin Dan Gazit Debiao Li Intradiscal quantitative chemical exchange saturation transfer MRI signal correlates with discogenic pain in human patients |
| description |
Abstract Low back pain (LBP) is often a result of a degenerative process in the intervertebral disc. The precise origin of discogenic pain is diagnosed by the invasive procedure of provocative discography (PD). Previously, we developed quantitative chemical exchange saturation transfer (qCEST) magnetic resonance imaging (MRI) to detect pH as a biomarker for discogenic pain. Based on these findings we initiated a clinical study with the goal to evaluate the correlation between qCEST values and PD results in LBP patients. Twenty five volunteers with chronic low back pain were subjected to T2-weighted (T2w) and qCEST MRI scans followed by PD. A total of 72 discs were analyzed. The average qCEST signal value of painful discs was significantly higher than non-painful discs (p = 0.012). The ratio between qCEST and normalized T2w was found to be significantly higher in painful discs compared to non-painful discs (p = 0.0022). A receiver operating characteristics (ROC) analysis indicated that qCEST/T2w ratio could be used to differentiate between painful and non-painful discs with 78% sensitivity and 81% specificity. The results of the study suggest that qCEST could be used for the diagnosis of discogenic pain, in conjunction with the commonly used T2w scan. |
| format |
article |
| author |
Gadi Pelled Margaux M. Salas Pei Han Howard E. Gill Karl A. Lautenschlager Tristan T. Lai Cameron M. Shawver Matthew B. Hoch Brandon J. Goff Aaron M. Betts Zhengwei Zhou Cody Lynch Grant Schroeder Maxim Bez Marcel M. Maya Catherine Bresee Zulma Gazit John P. McCallin Dan Gazit Debiao Li |
| author_facet |
Gadi Pelled Margaux M. Salas Pei Han Howard E. Gill Karl A. Lautenschlager Tristan T. Lai Cameron M. Shawver Matthew B. Hoch Brandon J. Goff Aaron M. Betts Zhengwei Zhou Cody Lynch Grant Schroeder Maxim Bez Marcel M. Maya Catherine Bresee Zulma Gazit John P. McCallin Dan Gazit Debiao Li |
| author_sort |
Gadi Pelled |
| title |
Intradiscal quantitative chemical exchange saturation transfer MRI signal correlates with discogenic pain in human patients |
| title_short |
Intradiscal quantitative chemical exchange saturation transfer MRI signal correlates with discogenic pain in human patients |
| title_full |
Intradiscal quantitative chemical exchange saturation transfer MRI signal correlates with discogenic pain in human patients |
| title_fullStr |
Intradiscal quantitative chemical exchange saturation transfer MRI signal correlates with discogenic pain in human patients |
| title_full_unstemmed |
Intradiscal quantitative chemical exchange saturation transfer MRI signal correlates with discogenic pain in human patients |
| title_sort |
intradiscal quantitative chemical exchange saturation transfer mri signal correlates with discogenic pain in human patients |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/1a3459a68fb84f2d89e23e8ca6981fe8 |
| work_keys_str_mv |
AT gadipelled intradiscalquantitativechemicalexchangesaturationtransfermrisignalcorrelateswithdiscogenicpaininhumanpatients AT margauxmsalas intradiscalquantitativechemicalexchangesaturationtransfermrisignalcorrelateswithdiscogenicpaininhumanpatients AT peihan intradiscalquantitativechemicalexchangesaturationtransfermrisignalcorrelateswithdiscogenicpaininhumanpatients AT howardegill intradiscalquantitativechemicalexchangesaturationtransfermrisignalcorrelateswithdiscogenicpaininhumanpatients AT karlalautenschlager intradiscalquantitativechemicalexchangesaturationtransfermrisignalcorrelateswithdiscogenicpaininhumanpatients AT tristantlai intradiscalquantitativechemicalexchangesaturationtransfermrisignalcorrelateswithdiscogenicpaininhumanpatients AT cameronmshawver intradiscalquantitativechemicalexchangesaturationtransfermrisignalcorrelateswithdiscogenicpaininhumanpatients AT matthewbhoch intradiscalquantitativechemicalexchangesaturationtransfermrisignalcorrelateswithdiscogenicpaininhumanpatients AT brandonjgoff intradiscalquantitativechemicalexchangesaturationtransfermrisignalcorrelateswithdiscogenicpaininhumanpatients AT aaronmbetts intradiscalquantitativechemicalexchangesaturationtransfermrisignalcorrelateswithdiscogenicpaininhumanpatients AT zhengweizhou intradiscalquantitativechemicalexchangesaturationtransfermrisignalcorrelateswithdiscogenicpaininhumanpatients AT codylynch intradiscalquantitativechemicalexchangesaturationtransfermrisignalcorrelateswithdiscogenicpaininhumanpatients AT grantschroeder intradiscalquantitativechemicalexchangesaturationtransfermrisignalcorrelateswithdiscogenicpaininhumanpatients AT maximbez intradiscalquantitativechemicalexchangesaturationtransfermrisignalcorrelateswithdiscogenicpaininhumanpatients AT marcelmmaya intradiscalquantitativechemicalexchangesaturationtransfermrisignalcorrelateswithdiscogenicpaininhumanpatients AT catherinebresee intradiscalquantitativechemicalexchangesaturationtransfermrisignalcorrelateswithdiscogenicpaininhumanpatients AT zulmagazit intradiscalquantitativechemicalexchangesaturationtransfermrisignalcorrelateswithdiscogenicpaininhumanpatients AT johnpmccallin intradiscalquantitativechemicalexchangesaturationtransfermrisignalcorrelateswithdiscogenicpaininhumanpatients AT dangazit intradiscalquantitativechemicalexchangesaturationtransfermrisignalcorrelateswithdiscogenicpaininhumanpatients AT debiaoli intradiscalquantitativechemicalexchangesaturationtransfermrisignalcorrelateswithdiscogenicpaininhumanpatients |
| _version_ |
1718381130742235136 |