Low levels of plasma endothelin-1 in patients with retinitis pigmentosa

Hiroshi Ohguro1, Yukihiko Mashima2, Mitsuru Nakazawa31Department of Ophthalmology, Sapporo Medical University School of Medicine, 2Department of Ophthalmology, Keio University School of Medicine, 3Department of Ophthalmology, Hirosaki University School of Medicine, JapanPurpose: The aim of this stud...

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Autores principales:	Hiroshi Ohguro, Yukihiko Mashima, Mitsuru Nakazawa
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/1a3afba277a441c48173ce9c26258eb3
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spelling	oai:doaj.org-article:1a3afba277a441c48173ce9c26258eb32021-12-02T00:34:33ZLow levels of plasma endothelin-1 in patients with retinitis pigmentosa1177-54671177-5483https://doaj.org/article/1a3afba277a441c48173ce9c26258eb32010-06-01T00:00:00Zhttp://www.dovepress.com/low-levels-of-plasma-endothelin-1-in-patients-with-retinitis-pigmentos-a4588https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Hiroshi Ohguro1, Yukihiko Mashima2, Mitsuru Nakazawa31Department of Ophthalmology, Sapporo Medical University School of Medicine, 2Department of Ophthalmology, Keio University School of Medicine, 3Department of Ophthalmology, Hirosaki University School of Medicine, JapanPurpose: The aim of this study was to elucidate the role of endothelin-1 (ET-1) in the pathophysiology of retinitis pigmentosa (RP).Methods: Plasma ET-1 levels and ophthalmic features in 50 RP patients were compared with those in 20 healthy-eye control subjects. Plasma ET-1 concentrations were determined using a commercially available enzyme-linked immunosorbent assay kit.Results: Mean plasma ET-1 levels of RP patients (1.88 &plusmn; 0.56 pg/mL) were significantly lower than those of control subjects (2.30 &plusmn; 0.30 pg/mL, Mann-Whitney&rsquo;s U test; P &lt; 0.01). However, ET-1 concentrations varied markedly in each patient. Among RP patients, a significant correlation of ET-1 concentrations was not observed in terms of its hereditary forms or other clinical factors.Conclusion: ET-1 may be important in the pathogenesis of RP, and measurement of its plasma concentrations may also contribute to additional insights into the retinal hemodynamics of RP.Keywords: endothelin-1, retinitis pigmentosa, retinal hemodynamics Hiroshi OhguroYukihiko MashimaMitsuru NakazawaDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2010, Iss default, Pp 569-573 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Hiroshi Ohguro Yukihiko Mashima Mitsuru Nakazawa Low levels of plasma endothelin-1 in patients with retinitis pigmentosa
description	Hiroshi Ohguro1, Yukihiko Mashima2, Mitsuru Nakazawa31Department of Ophthalmology, Sapporo Medical University School of Medicine, 2Department of Ophthalmology, Keio University School of Medicine, 3Department of Ophthalmology, Hirosaki University School of Medicine, JapanPurpose: The aim of this study was to elucidate the role of endothelin-1 (ET-1) in the pathophysiology of retinitis pigmentosa (RP).Methods: Plasma ET-1 levels and ophthalmic features in 50 RP patients were compared with those in 20 healthy-eye control subjects. Plasma ET-1 concentrations were determined using a commercially available enzyme-linked immunosorbent assay kit.Results: Mean plasma ET-1 levels of RP patients (1.88 &plusmn; 0.56 pg/mL) were significantly lower than those of control subjects (2.30 &plusmn; 0.30 pg/mL, Mann-Whitney&rsquo;s U test; P &lt; 0.01). However, ET-1 concentrations varied markedly in each patient. Among RP patients, a significant correlation of ET-1 concentrations was not observed in terms of its hereditary forms or other clinical factors.Conclusion: ET-1 may be important in the pathogenesis of RP, and measurement of its plasma concentrations may also contribute to additional insights into the retinal hemodynamics of RP.Keywords: endothelin-1, retinitis pigmentosa, retinal hemodynamics
format	article
author	Hiroshi Ohguro Yukihiko Mashima Mitsuru Nakazawa
author_facet	Hiroshi Ohguro Yukihiko Mashima Mitsuru Nakazawa
author_sort	Hiroshi Ohguro
title	Low levels of plasma endothelin-1 in patients with retinitis pigmentosa
title_short	Low levels of plasma endothelin-1 in patients with retinitis pigmentosa
title_full	Low levels of plasma endothelin-1 in patients with retinitis pigmentosa
title_fullStr	Low levels of plasma endothelin-1 in patients with retinitis pigmentosa
title_full_unstemmed	Low levels of plasma endothelin-1 in patients with retinitis pigmentosa
title_sort	low levels of plasma endothelin-1 in patients with retinitis pigmentosa
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/1a3afba277a441c48173ce9c26258eb3
work_keys_str_mv	AT hiroshiohguro lowlevelsofplasmaendothelin1inpatientswithretinitispigmentosa AT yukihikomashima lowlevelsofplasmaendothelin1inpatientswithretinitispigmentosa AT mitsurunakazawa lowlevelsofplasmaendothelin1inpatientswithretinitispigmentosa
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Low levels of plasma endothelin-1 in patients with retinitis pigmentosa

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