Formulation And Antioxidant Property Of Bitter Melon Seeds Oil Loaded Into SNEDDS Systems As A Nutraceutical

Bitter melon seeds oil is less soluble in the gastrointestinal tract and has low absorption. Therefore, a self-nanoemulsion dosage form needed to support its absorption and increase its stability. This study aimed to formulate bitter melon seeds oil into a self-nano emulsifying drug delivery system...

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Autores principales:	Lina Winarti, Lusia Oktora Ruma Kumala Sari, Evi Umayah Ulfa, Dwi Ayu Samsuri
Formato:	article
Lenguaje:	EN
Publicado:	Universitas Gadjah Mada 2021
Materias:	bitter melon seeds oil, nutraceutical, snedds, antioxidant activity Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/1a3ca32dc41b48f39979a33d3b68f125
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spelling	oai:doaj.org-article:1a3ca32dc41b48f39979a33d3b68f1252021-11-15T06:08:46ZFormulation And Antioxidant Property Of Bitter Melon Seeds Oil Loaded Into SNEDDS Systems As A Nutraceutical2338-94272338-948610.22146/ijp.1334https://doaj.org/article/1a3ca32dc41b48f39979a33d3b68f1252021-09-01T00:00:00Zhttps://jurnal.ugm.ac.id/v3/IJP/article/view/1334https://doaj.org/toc/2338-9427https://doaj.org/toc/2338-9486Bitter melon seeds oil is less soluble in the gastrointestinal tract and has low absorption. Therefore, a self-nanoemulsion dosage form needed to support its absorption and increase its stability. This study aimed to formulate bitter melon seeds oil into a self-nano emulsifying drug delivery system (SNEDDS) and evaluate its antioxidant activity using the Ferric Reducing Antioxidant Power (FRAP) method. The SNEDDS formulation uses bitter melon seed oil as the active ingredient and the oil phase, cremophor RH 40 as a surfactant, and glycerin as a co-surfactant. The results showed that the best SNEDDS formula obtains a ratio of oil: Smix (surfactant mixture) of 1:4. The best formula transmittance was 97.35 ± 0.04% with an emulsification time of 15.69 ± 0.06 seconds, a pH value of 6.87 ± 0.08, and a particle size of 31.8 ± 16.3 nm. Thermodynamic stability and robustness to dilution tests show the preparation is stable and resistant to various dilutions and pH. The antioxidant activity of bitter melon seed oil before and after being formulated into SNEDDS resulted in 62.73% and 50.31% reducing power. This result is not differences significantly. This study concluded that bitter melon seeds oil SNEDDS has good physical characteristics, stability, and no antioxidant activity changes.Lina WinartiLusia Oktora Ruma Kumala SariEvi Umayah UlfaDwi Ayu SamsuriUniversitas Gadjah Madaarticlebitter melon seeds oil, nutraceutical, snedds, antioxidant activityPharmacy and materia medicaRS1-441ENIndonesian Journal of Pharmacy, Pp 385–393-385–393 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bitter melon seeds oil, nutraceutical, snedds, antioxidant activity Pharmacy and materia medica RS1-441
spellingShingle	bitter melon seeds oil, nutraceutical, snedds, antioxidant activity Pharmacy and materia medica RS1-441 Lina Winarti Lusia Oktora Ruma Kumala Sari Evi Umayah Ulfa Dwi Ayu Samsuri Formulation And Antioxidant Property Of Bitter Melon Seeds Oil Loaded Into SNEDDS Systems As A Nutraceutical
description	Bitter melon seeds oil is less soluble in the gastrointestinal tract and has low absorption. Therefore, a self-nanoemulsion dosage form needed to support its absorption and increase its stability. This study aimed to formulate bitter melon seeds oil into a self-nano emulsifying drug delivery system (SNEDDS) and evaluate its antioxidant activity using the Ferric Reducing Antioxidant Power (FRAP) method. The SNEDDS formulation uses bitter melon seed oil as the active ingredient and the oil phase, cremophor RH 40 as a surfactant, and glycerin as a co-surfactant. The results showed that the best SNEDDS formula obtains a ratio of oil: Smix (surfactant mixture) of 1:4. The best formula transmittance was 97.35 ± 0.04% with an emulsification time of 15.69 ± 0.06 seconds, a pH value of 6.87 ± 0.08, and a particle size of 31.8 ± 16.3 nm. Thermodynamic stability and robustness to dilution tests show the preparation is stable and resistant to various dilutions and pH. The antioxidant activity of bitter melon seed oil before and after being formulated into SNEDDS resulted in 62.73% and 50.31% reducing power. This result is not differences significantly. This study concluded that bitter melon seeds oil SNEDDS has good physical characteristics, stability, and no antioxidant activity changes.
format	article
author	Lina Winarti Lusia Oktora Ruma Kumala Sari Evi Umayah Ulfa Dwi Ayu Samsuri
author_facet	Lina Winarti Lusia Oktora Ruma Kumala Sari Evi Umayah Ulfa Dwi Ayu Samsuri
author_sort	Lina Winarti
title	Formulation And Antioxidant Property Of Bitter Melon Seeds Oil Loaded Into SNEDDS Systems As A Nutraceutical
title_short	Formulation And Antioxidant Property Of Bitter Melon Seeds Oil Loaded Into SNEDDS Systems As A Nutraceutical
title_full	Formulation And Antioxidant Property Of Bitter Melon Seeds Oil Loaded Into SNEDDS Systems As A Nutraceutical
title_fullStr	Formulation And Antioxidant Property Of Bitter Melon Seeds Oil Loaded Into SNEDDS Systems As A Nutraceutical
title_full_unstemmed	Formulation And Antioxidant Property Of Bitter Melon Seeds Oil Loaded Into SNEDDS Systems As A Nutraceutical
title_sort	formulation and antioxidant property of bitter melon seeds oil loaded into snedds systems as a nutraceutical
publisher	Universitas Gadjah Mada
publishDate	2021
url	https://doaj.org/article/1a3ca32dc41b48f39979a33d3b68f125
work_keys_str_mv	AT linawinarti formulationandantioxidantpropertyofbittermelonseedsoilloadedintosneddssystemsasanutraceutical AT lusiaoktorarumakumalasari formulationandantioxidantpropertyofbittermelonseedsoilloadedintosneddssystemsasanutraceutical AT eviumayahulfa formulationandantioxidantpropertyofbittermelonseedsoilloadedintosneddssystemsasanutraceutical AT dwiayusamsuri formulationandantioxidantpropertyofbittermelonseedsoilloadedintosneddssystemsasanutraceutical
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Formulation And Antioxidant Property Of Bitter Melon Seeds Oil Loaded Into SNEDDS Systems As A Nutraceutical

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