Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig

Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig

Cancers evolve as they progress under differing selective pressures. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, the authors present the method TrackSig the estimates evolutionary trajectories of somatic mutational processes from single bulk tumour data.

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Autores principales: Yulia Rubanova, Ruian Shi, Caitlin F. Harrigan, Roujia Li, Jeff Wintersinger, Nil Sahin, Amit Deshwar, PCAWG Evolution and Heterogeneity Working Group, Quaid Morris, PCAWG Consortium
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/1a3e0a924fa54deda33cd083d4a87624
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https://doaj.org/article/1a3e0a924fa54deda33cd083d4a87624

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