The Nutritional Supply of Iodine and Selenium Affects Thyroid Hormone Axis Related Endpoints in Mice

Selenium and iodine are the two central trace elements for the homeostasis of thyroid hormones but additional trace elements such as iron, zinc, and copper are also involved. To compare the primary effects of inadequate intake of selenium and iodine on the thyroid gland, as well as the target organs...

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Autores principales:	Kristina Lossow, Kostja Renko, Maria Schwarz, Lutz Schomburg, Tanja Schwerdtle, Anna Patricia Kipp
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	selenium iodine thyroid kidney liver mouse Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/1a431dab710f4f868fb97100240a2240
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spelling	oai:doaj.org-article:1a431dab710f4f868fb97100240a22402021-11-25T18:33:54ZThe Nutritional Supply of Iodine and Selenium Affects Thyroid Hormone Axis Related Endpoints in Mice10.3390/nu131137732072-6643https://doaj.org/article/1a431dab710f4f868fb97100240a22402021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3773https://doaj.org/toc/2072-6643Selenium and iodine are the two central trace elements for the homeostasis of thyroid hormones but additional trace elements such as iron, zinc, and copper are also involved. To compare the primary effects of inadequate intake of selenium and iodine on the thyroid gland, as well as the target organs of thyroid hormones such as liver and kidney, mice were subjected to an eight-week dietary intervention with low versus adequate selenium and iodine supply. Analysis of trace element levels in serum, liver, and kidney demonstrated a successful intervention. Markers of the selenium status were unaffected by the iodine supply. The thyroid gland was able to maintain serum thyroxine levels even under selenium-deficient conditions, despite reduced selenoprotein expression in liver and kidney, including deiodinase type 1. Thyroid hormone target genes responded to the altered selenium and iodine supply, whereas the iron, zinc, and copper homeostasis remained unaffected. There was a notable interaction between thyroid hormones and copper, which requires further clarification. Overall, the effects of an altered selenium and iodine supply were pronounced in thyroid hormone target tissues, but not in the thyroid gland.Kristina LossowKostja RenkoMaria SchwarzLutz SchomburgTanja SchwerdtleAnna Patricia KippMDPI AGarticleseleniumiodinethyroidkidneylivermouseNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3773, p 3773 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	selenium iodine thyroid kidney liver mouse Nutrition. Foods and food supply TX341-641
spellingShingle	selenium iodine thyroid kidney liver mouse Nutrition. Foods and food supply TX341-641 Kristina Lossow Kostja Renko Maria Schwarz Lutz Schomburg Tanja Schwerdtle Anna Patricia Kipp The Nutritional Supply of Iodine and Selenium Affects Thyroid Hormone Axis Related Endpoints in Mice
description	Selenium and iodine are the two central trace elements for the homeostasis of thyroid hormones but additional trace elements such as iron, zinc, and copper are also involved. To compare the primary effects of inadequate intake of selenium and iodine on the thyroid gland, as well as the target organs of thyroid hormones such as liver and kidney, mice were subjected to an eight-week dietary intervention with low versus adequate selenium and iodine supply. Analysis of trace element levels in serum, liver, and kidney demonstrated a successful intervention. Markers of the selenium status were unaffected by the iodine supply. The thyroid gland was able to maintain serum thyroxine levels even under selenium-deficient conditions, despite reduced selenoprotein expression in liver and kidney, including deiodinase type 1. Thyroid hormone target genes responded to the altered selenium and iodine supply, whereas the iron, zinc, and copper homeostasis remained unaffected. There was a notable interaction between thyroid hormones and copper, which requires further clarification. Overall, the effects of an altered selenium and iodine supply were pronounced in thyroid hormone target tissues, but not in the thyroid gland.
format	article
author	Kristina Lossow Kostja Renko Maria Schwarz Lutz Schomburg Tanja Schwerdtle Anna Patricia Kipp
author_facet	Kristina Lossow Kostja Renko Maria Schwarz Lutz Schomburg Tanja Schwerdtle Anna Patricia Kipp
author_sort	Kristina Lossow
title	The Nutritional Supply of Iodine and Selenium Affects Thyroid Hormone Axis Related Endpoints in Mice
title_short	The Nutritional Supply of Iodine and Selenium Affects Thyroid Hormone Axis Related Endpoints in Mice
title_full	The Nutritional Supply of Iodine and Selenium Affects Thyroid Hormone Axis Related Endpoints in Mice
title_fullStr	The Nutritional Supply of Iodine and Selenium Affects Thyroid Hormone Axis Related Endpoints in Mice
title_full_unstemmed	The Nutritional Supply of Iodine and Selenium Affects Thyroid Hormone Axis Related Endpoints in Mice
title_sort	nutritional supply of iodine and selenium affects thyroid hormone axis related endpoints in mice
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1a431dab710f4f868fb97100240a2240
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The Nutritional Supply of Iodine and Selenium Affects Thyroid Hormone Axis Related Endpoints in Mice

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