Cardiac manifestations of Familial Mediterranean fever

Familial Mediterranean fever (FMF) is autoinflammatory disorder characterized by sporadic attacks of fever, peritonitis, pleuritis, and arthritis. It is mainly seen in patients from Mediterranean origins, but it is now reported more frequently in Europe and North America due to immigration. To analy...

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Autores principales:	Ahmad Alsarah, Osama Alsara, Heather S Laird-Fick
Formato:	article
Lenguaje:	EN
Publicado:	Thieme Medical and Scientific Publishers Pvt. Ltd. 2017
Materias:	atherosclerosis cardiomyopathy coronary artery disease familial mediterranean fever pericarditis Medicine R
Acceso en línea:	https://doaj.org/article/1a4437596fe44bed8d2cede531e3e73f
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spelling	oai:doaj.org-article:1a4437596fe44bed8d2cede531e3e73f2021-12-02T16:37:41ZCardiac manifestations of Familial Mediterranean fever2231-07702249-446410.4103/ajm.AJM_78_17https://doaj.org/article/1a4437596fe44bed8d2cede531e3e73f2017-10-01T00:00:00Zhttp://www.thieme-connect.de/DOI/DOI?10.4103/ajm.AJM_78_17https://doaj.org/toc/2231-0770https://doaj.org/toc/2249-4464Familial Mediterranean fever (FMF) is autoinflammatory disorder characterized by sporadic attacks of fever, peritonitis, pleuritis, and arthritis. It is mainly seen in patients from Mediterranean origins, but it is now reported more frequently in Europe and North America due to immigration. To analyze the data on the cardiovascular manifestations in FMF patients, we searched PubMed using the terms “Familial Mediterranean Fever” or “FMF” in combination with other key words including “cardiovascular diseases” “pericardial diseases” “atherosclerosis” “coronary artery diseases” “cardiomyopathy” “pulmonary hypertension” or “valvular diseases.” suggested several mechanisms to explain the cardiac involvements in FMF including the ongoing inflammation and the amyloid deposits in the heart and vessels' walls at the advanced stages of FMF. The course of these manifestations varies widely, but it can associate with poor prognosis in some cases such as with pulmonary hypertension. Interestingly, Colchicine, which is the cornerstone therapy of FMF, plays a vital role in treating and preventing some of these disorders. In this article, In this article, we will discuss the incidence, pathophysiology, and prognosis of the various cardiac manifestations affecting FMF patients.Ahmad AlsarahOsama AlsaraHeather S Laird-FickThieme Medical and Scientific Publishers Pvt. Ltd.articleatherosclerosiscardiomyopathycoronary artery diseasefamilial mediterranean feverpericarditisMedicineRENAvicenna Journal of Medicine, Vol 07, Iss 04, Pp 158-163 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	atherosclerosis cardiomyopathy coronary artery disease familial mediterranean fever pericarditis Medicine R
spellingShingle	atherosclerosis cardiomyopathy coronary artery disease familial mediterranean fever pericarditis Medicine R Ahmad Alsarah Osama Alsara Heather S Laird-Fick Cardiac manifestations of Familial Mediterranean fever
description	Familial Mediterranean fever (FMF) is autoinflammatory disorder characterized by sporadic attacks of fever, peritonitis, pleuritis, and arthritis. It is mainly seen in patients from Mediterranean origins, but it is now reported more frequently in Europe and North America due to immigration. To analyze the data on the cardiovascular manifestations in FMF patients, we searched PubMed using the terms “Familial Mediterranean Fever” or “FMF” in combination with other key words including “cardiovascular diseases” “pericardial diseases” “atherosclerosis” “coronary artery diseases” “cardiomyopathy” “pulmonary hypertension” or “valvular diseases.” suggested several mechanisms to explain the cardiac involvements in FMF including the ongoing inflammation and the amyloid deposits in the heart and vessels' walls at the advanced stages of FMF. The course of these manifestations varies widely, but it can associate with poor prognosis in some cases such as with pulmonary hypertension. Interestingly, Colchicine, which is the cornerstone therapy of FMF, plays a vital role in treating and preventing some of these disorders. In this article, In this article, we will discuss the incidence, pathophysiology, and prognosis of the various cardiac manifestations affecting FMF patients.
format	article
author	Ahmad Alsarah Osama Alsara Heather S Laird-Fick
author_facet	Ahmad Alsarah Osama Alsara Heather S Laird-Fick
author_sort	Ahmad Alsarah
title	Cardiac manifestations of Familial Mediterranean fever
title_short	Cardiac manifestations of Familial Mediterranean fever
title_full	Cardiac manifestations of Familial Mediterranean fever
title_fullStr	Cardiac manifestations of Familial Mediterranean fever
title_full_unstemmed	Cardiac manifestations of Familial Mediterranean fever
title_sort	cardiac manifestations of familial mediterranean fever
publisher	Thieme Medical and Scientific Publishers Pvt. Ltd.
publishDate	2017
url	https://doaj.org/article/1a4437596fe44bed8d2cede531e3e73f
work_keys_str_mv	AT ahmadalsarah cardiacmanifestationsoffamilialmediterraneanfever AT osamaalsara cardiacmanifestationsoffamilialmediterraneanfever AT heatherslairdfick cardiacmanifestationsoffamilialmediterraneanfever
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Cardiac manifestations of Familial Mediterranean fever

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