Mechanistic insight into TRIP13-catalyzed Mad2 structural transition and spindle checkpoint silencing

The spindle checkpoint ensures the fidelity of chromosome segregation during mitosis and meiosis. Here the authors use a combination of biochemical and structural biology approaches to show how the TRIP13 ATPase and its adaptor, p31comet, catalyze the conversion of the checkpoint protein Mad2 betwee...

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Autores principales:	Melissa L. Brulotte, Byung-Cheon Jeong, Faxiang Li, Bing Li, Eric B. Yu, Qiong Wu, Chad A. Brautigam, Hongtao Yu, Xuelian Luo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1a45bc1b1cac4929bf939b9c72673234
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spelling	oai:doaj.org-article:1a45bc1b1cac4929bf939b9c726732342021-12-02T17:06:18ZMechanistic insight into TRIP13-catalyzed Mad2 structural transition and spindle checkpoint silencing10.1038/s41467-017-02012-22041-1723https://doaj.org/article/1a45bc1b1cac4929bf939b9c726732342017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02012-2https://doaj.org/toc/2041-1723The spindle checkpoint ensures the fidelity of chromosome segregation during mitosis and meiosis. Here the authors use a combination of biochemical and structural biology approaches to show how the TRIP13 ATPase and its adaptor, p31comet, catalyze the conversion of the checkpoint protein Mad2 between latent and active formsMelissa L. BrulotteByung-Cheon JeongFaxiang LiBing LiEric B. YuQiong WuChad A. BrautigamHongtao YuXuelian LuoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Melissa L. Brulotte Byung-Cheon Jeong Faxiang Li Bing Li Eric B. Yu Qiong Wu Chad A. Brautigam Hongtao Yu Xuelian Luo Mechanistic insight into TRIP13-catalyzed Mad2 structural transition and spindle checkpoint silencing
description	The spindle checkpoint ensures the fidelity of chromosome segregation during mitosis and meiosis. Here the authors use a combination of biochemical and structural biology approaches to show how the TRIP13 ATPase and its adaptor, p31comet, catalyze the conversion of the checkpoint protein Mad2 between latent and active forms
format	article
author	Melissa L. Brulotte Byung-Cheon Jeong Faxiang Li Bing Li Eric B. Yu Qiong Wu Chad A. Brautigam Hongtao Yu Xuelian Luo
author_facet	Melissa L. Brulotte Byung-Cheon Jeong Faxiang Li Bing Li Eric B. Yu Qiong Wu Chad A. Brautigam Hongtao Yu Xuelian Luo
author_sort	Melissa L. Brulotte
title	Mechanistic insight into TRIP13-catalyzed Mad2 structural transition and spindle checkpoint silencing
title_short	Mechanistic insight into TRIP13-catalyzed Mad2 structural transition and spindle checkpoint silencing
title_full	Mechanistic insight into TRIP13-catalyzed Mad2 structural transition and spindle checkpoint silencing
title_fullStr	Mechanistic insight into TRIP13-catalyzed Mad2 structural transition and spindle checkpoint silencing
title_full_unstemmed	Mechanistic insight into TRIP13-catalyzed Mad2 structural transition and spindle checkpoint silencing
title_sort	mechanistic insight into trip13-catalyzed mad2 structural transition and spindle checkpoint silencing
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1a45bc1b1cac4929bf939b9c72673234
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_version_	1718381660890726400

Mechanistic insight into TRIP13-catalyzed Mad2 structural transition and spindle checkpoint silencing

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