Minimal change disease following the Moderna COVID-19 vaccine: first case report

Abstract Background There have been cases of minimal change disease (MCD) reported following previous vaccines. During the COVID-19 era, only 3 cases of new-onset MCD and a case of MCD relapse were reported following the Pfizer-BioNTech COVID-19 vaccine. We herein report the first case of MCD after...

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Autores principales:	Shaefiq Thappy, Sherin R. Thalappil, Shahem Abbarh, Abdulrahman Al-Mashdali, Mohammed Akhtar, Mohamad M. Alkadi
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Nephrotic syndrome Immunization. Minimal change disease Case report Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/1a52fc8b514e4e0c95096deadb0d8850
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spelling	oai:doaj.org-article:1a52fc8b514e4e0c95096deadb0d88502021-11-14T12:43:45ZMinimal change disease following the Moderna COVID-19 vaccine: first case report10.1186/s12882-021-02583-91471-2369https://doaj.org/article/1a52fc8b514e4e0c95096deadb0d88502021-11-01T00:00:00Zhttps://doi.org/10.1186/s12882-021-02583-9https://doaj.org/toc/1471-2369Abstract Background There have been cases of minimal change disease (MCD) reported following previous vaccines. During the COVID-19 era, only 3 cases of new-onset MCD and a case of MCD relapse were reported following the Pfizer-BioNTech COVID-19 vaccine. We herein report the first case of MCD after receiving the Moderna COVID-19 vaccine. Case presentation A 43-year-old man presented to hospital 3 weeks after receiving the first dose of the Moderna vaccine, with both bilateral lower extremities and scrotal edema. He initially developed a sudden-onset bilateral lower extremities swelling on day 7 post-vaccine. He, then, developed dyspnea and scrotal swelling over a time span of 2 weeks. On physical examination, his blood pressure was 150/92 mmHg. There was a decreased air entry at lung bases, bilateral lower extremities and scrotal edema. Labs revealed hypoalbuminemia, hyperlipidemia and 15 g of proteinuria. His immunologic and serologic work up was negative. Renal biopsy showed concomitant MCD and IgA nephropathy. Patient was treated with oral steroids and had a good response; his edema resolved, serum albumin improved, and proteinuria decreased to 1 g within 2 weeks of treatment. Conclusions To the best of our knowledge, MCD has not been previously reported after receiving the Moderna COVID-19 vaccine. It remains unclear whether the COVID-19 mRNA vaccines are associated with the development of MCD, or it coincided with the mass vaccination. Further studies are needed to determine the incidence of MCD post COVID-19 vaccines and the underlying pathophysiology of glomerular injury post vaccination.Shaefiq ThappySherin R. ThalappilShahem AbbarhAbdulrahman Al-MashdaliMohammed AkhtarMohamad M. AlkadiBMCarticleNephrotic syndromeImmunization.Minimal change diseaseCase reportDiseases of the genitourinary system. UrologyRC870-923ENBMC Nephrology, Vol 22, Iss 1, Pp 1-4 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Nephrotic syndrome Immunization. Minimal change disease Case report Diseases of the genitourinary system. Urology RC870-923
spellingShingle	Nephrotic syndrome Immunization. Minimal change disease Case report Diseases of the genitourinary system. Urology RC870-923 Shaefiq Thappy Sherin R. Thalappil Shahem Abbarh Abdulrahman Al-Mashdali Mohammed Akhtar Mohamad M. Alkadi Minimal change disease following the Moderna COVID-19 vaccine: first case report
description	Abstract Background There have been cases of minimal change disease (MCD) reported following previous vaccines. During the COVID-19 era, only 3 cases of new-onset MCD and a case of MCD relapse were reported following the Pfizer-BioNTech COVID-19 vaccine. We herein report the first case of MCD after receiving the Moderna COVID-19 vaccine. Case presentation A 43-year-old man presented to hospital 3 weeks after receiving the first dose of the Moderna vaccine, with both bilateral lower extremities and scrotal edema. He initially developed a sudden-onset bilateral lower extremities swelling on day 7 post-vaccine. He, then, developed dyspnea and scrotal swelling over a time span of 2 weeks. On physical examination, his blood pressure was 150/92 mmHg. There was a decreased air entry at lung bases, bilateral lower extremities and scrotal edema. Labs revealed hypoalbuminemia, hyperlipidemia and 15 g of proteinuria. His immunologic and serologic work up was negative. Renal biopsy showed concomitant MCD and IgA nephropathy. Patient was treated with oral steroids and had a good response; his edema resolved, serum albumin improved, and proteinuria decreased to 1 g within 2 weeks of treatment. Conclusions To the best of our knowledge, MCD has not been previously reported after receiving the Moderna COVID-19 vaccine. It remains unclear whether the COVID-19 mRNA vaccines are associated with the development of MCD, or it coincided with the mass vaccination. Further studies are needed to determine the incidence of MCD post COVID-19 vaccines and the underlying pathophysiology of glomerular injury post vaccination.
format	article
author	Shaefiq Thappy Sherin R. Thalappil Shahem Abbarh Abdulrahman Al-Mashdali Mohammed Akhtar Mohamad M. Alkadi
author_facet	Shaefiq Thappy Sherin R. Thalappil Shahem Abbarh Abdulrahman Al-Mashdali Mohammed Akhtar Mohamad M. Alkadi
author_sort	Shaefiq Thappy
title	Minimal change disease following the Moderna COVID-19 vaccine: first case report
title_short	Minimal change disease following the Moderna COVID-19 vaccine: first case report
title_full	Minimal change disease following the Moderna COVID-19 vaccine: first case report
title_fullStr	Minimal change disease following the Moderna COVID-19 vaccine: first case report
title_full_unstemmed	Minimal change disease following the Moderna COVID-19 vaccine: first case report
title_sort	minimal change disease following the moderna covid-19 vaccine: first case report
publisher	BMC
publishDate	2021
url	https://doaj.org/article/1a52fc8b514e4e0c95096deadb0d8850
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Minimal change disease following the Moderna COVID-19 vaccine: first case report

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