Depth sensitivity and source-detector separations for near infrared spectroscopy based on the Colin27 brain template.

Understanding the spatial and depth sensitivity of non-invasive near-infrared spectroscopy (NIRS) measurements to brain tissue-i.e., near-infrared neuromonitoring (NIN) - is essential for designing experiments as well as interpreting research findings. However, a thorough characterization of such se...

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Autores principales:	Gary E Strangman, Zhi Li, Quan Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1a57f43a98de4b818b4179d129f34859
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spelling	oai:doaj.org-article:1a57f43a98de4b818b4179d129f348592021-11-18T09:01:46ZDepth sensitivity and source-detector separations for near infrared spectroscopy based on the Colin27 brain template.1932-620310.1371/journal.pone.0066319https://doaj.org/article/1a57f43a98de4b818b4179d129f348592013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23936292/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Understanding the spatial and depth sensitivity of non-invasive near-infrared spectroscopy (NIRS) measurements to brain tissue-i.e., near-infrared neuromonitoring (NIN) - is essential for designing experiments as well as interpreting research findings. However, a thorough characterization of such sensitivity in realistic head models has remained unavailable. In this study, we conducted 3,555 Monte Carlo (MC) simulations to densely cover the scalp of a well-characterized, adult male template brain (Colin27). We sought to evaluate: (i) the spatial sensitivity profile of NIRS to brain tissue as a function of source-detector separation, (ii) the NIRS sensitivity to brain tissue as a function of depth in this realistic and complex head model, and (iii) the effect of NIRS instrument sensitivity on detecting brain activation. We found that increasing the source-detector (SD) separation from 20 to 65 mm provides monotonic increases in sensitivity to brain tissue. For every 10 mm increase in SD separation (up to ~45 mm), sensitivity to gray matter increased an additional 4%. Our analyses also demonstrate that sensitivity in depth (S) decreases exponentially, with a "rule-of-thumb" formula S=0.75*0.85(depth). Thus, while the depth sensitivity of NIRS is not strictly limited, NIN signals in adult humans are strongly biased towards the outermost 10-15 mm of intracranial space. These general results, along with the detailed quantitation of sensitivity estimates around the head, can provide detailed guidance for interpreting the likely sources of NIRS signals, as well as help NIRS investigators design and plan better NIRS experiments, head probes and instruments.Gary E StrangmanZhi LiQuan ZhangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 8, p e66319 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gary E Strangman Zhi Li Quan Zhang Depth sensitivity and source-detector separations for near infrared spectroscopy based on the Colin27 brain template.
description	Understanding the spatial and depth sensitivity of non-invasive near-infrared spectroscopy (NIRS) measurements to brain tissue-i.e., near-infrared neuromonitoring (NIN) - is essential for designing experiments as well as interpreting research findings. However, a thorough characterization of such sensitivity in realistic head models has remained unavailable. In this study, we conducted 3,555 Monte Carlo (MC) simulations to densely cover the scalp of a well-characterized, adult male template brain (Colin27). We sought to evaluate: (i) the spatial sensitivity profile of NIRS to brain tissue as a function of source-detector separation, (ii) the NIRS sensitivity to brain tissue as a function of depth in this realistic and complex head model, and (iii) the effect of NIRS instrument sensitivity on detecting brain activation. We found that increasing the source-detector (SD) separation from 20 to 65 mm provides monotonic increases in sensitivity to brain tissue. For every 10 mm increase in SD separation (up to ~45 mm), sensitivity to gray matter increased an additional 4%. Our analyses also demonstrate that sensitivity in depth (S) decreases exponentially, with a "rule-of-thumb" formula S=0.75*0.85(depth). Thus, while the depth sensitivity of NIRS is not strictly limited, NIN signals in adult humans are strongly biased towards the outermost 10-15 mm of intracranial space. These general results, along with the detailed quantitation of sensitivity estimates around the head, can provide detailed guidance for interpreting the likely sources of NIRS signals, as well as help NIRS investigators design and plan better NIRS experiments, head probes and instruments.
format	article
author	Gary E Strangman Zhi Li Quan Zhang
author_facet	Gary E Strangman Zhi Li Quan Zhang
author_sort	Gary E Strangman
title	Depth sensitivity and source-detector separations for near infrared spectroscopy based on the Colin27 brain template.
title_short	Depth sensitivity and source-detector separations for near infrared spectroscopy based on the Colin27 brain template.
title_full	Depth sensitivity and source-detector separations for near infrared spectroscopy based on the Colin27 brain template.
title_fullStr	Depth sensitivity and source-detector separations for near infrared spectroscopy based on the Colin27 brain template.
title_full_unstemmed	Depth sensitivity and source-detector separations for near infrared spectroscopy based on the Colin27 brain template.
title_sort	depth sensitivity and source-detector separations for near infrared spectroscopy based on the colin27 brain template.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/1a57f43a98de4b818b4179d129f34859
work_keys_str_mv	AT garyestrangman depthsensitivityandsourcedetectorseparationsfornearinfraredspectroscopybasedonthecolin27braintemplate AT zhili depthsensitivityandsourcedetectorseparationsfornearinfraredspectroscopybasedonthecolin27braintemplate AT quanzhang depthsensitivityandsourcedetectorseparationsfornearinfraredspectroscopybasedonthecolin27braintemplate
_version_	1718421009396137984

Depth sensitivity and source-detector separations for near infrared spectroscopy based on the Colin27 brain template.

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