Pathogenic characteristics of intracellular infection in chlamydiosis

This review analyzes scientific data and systematized information regarding microbiological aspects and pathogenesis of chlamydia infection. Chlamydia are obligate intracellular microorganisms that are sensitive to any human cells where energy parasitism is possible: various types of epithelium, fib...

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Autores principales:	A. N. Markina, T. A. Kapustina, O. V. Parilova, E. V. Belova
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2021
Materias:	chlamydia infection respiratory chlamydiosis anti-chlamydia immunity chlamydia persistence pathogenesis immunity Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/1a5b2947fbb84b1193150982bb486e4c
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spelling	oai:doaj.org-article:1a5b2947fbb84b1193150982bb486e4c2021-11-22T07:09:55ZPathogenic characteristics of intracellular infection in chlamydiosis2220-76192313-739810.15789/2220-7619-PCO-1213https://doaj.org/article/1a5b2947fbb84b1193150982bb486e4c2021-06-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/1213https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398This review analyzes scientific data and systematized information regarding microbiological aspects and pathogenesis of chlamydia infection. Chlamydia are obligate intracellular microorganisms that are sensitive to any human cells where energy parasitism is possible: various types of epithelium, fibrocytes, histiocytes, glial and muscle cells, squamous epithelium of the meninges and eyeball, neurons, monocytes, macrophages. Structure, chemical composition and enzymatic activity of Chlamydia closely resemble those in Gram-negative bacteria, as they retain their morphological identity throughout the life cycle, possess cell wall, ribosomes, DNA, RNA, biochemical elements of glycolysis, tissue respiration, peptose production being sensitive to some broad-spectrum antibiotics, and are able to vegetative form division. In recent decades, the pathogenesis and clinical symptoms of chlamydial lesions in the urogenital tract, nervous, cardiovascular, musculoskeletal and bronchopulmonary systems have been actively studied, and new approaches and treatment schemes for chlamydia-infected patients are still developing. Over many decades, Chlamydia infection has been an important and urgent problem, not only due to its high prevalence, but also because of high rate of complications negatively affecting populational health and related demographic parameters. Chlamydia causes multiple diseases resulting in chronization of inflammatory process in all human organs and systems, and affects reproduction of population. Mandatory statistical recording of chlamydiosis cases introduced as early as in 1994 in the Russian Federation does not reflect the actual incidence rate. A rise in number of inflammatory diseases of the upper respiratory tract caused by Chlamydia undoubtedly increases its etiological importance, but data regarding etiopathogenetic role of Chlamydia in ENT pathology are ambiguous and contradictory. Available publications describe a large range of variation in rate of detected Chlamydia due to poor awareness of doctors about the microbiological properties of chlamydia, pathogenetic and clinical features of clinical signs of this infection, and lack of common and clear understanding on the algorithms for identifying and treating chlamydiosis. Since the majority of chlamydia-associated nosological forms are asymptomatic, knowing pathogenetic features of related will allow to prevent the spread of the infection and reduce subsequent socio-economic consequences.A. N. MarkinaT. A. KapustinaO. V. ParilovaE. V. BelovaSankt-Peterburg : NIIÈM imeni Pasteraarticlechlamydia infectionrespiratory chlamydiosisanti-chlamydia immunitychlamydia persistencepathogenesisimmunityInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 11, Iss 3, Pp 423-432 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	chlamydia infection respiratory chlamydiosis anti-chlamydia immunity chlamydia persistence pathogenesis immunity Infectious and parasitic diseases RC109-216
spellingShingle	chlamydia infection respiratory chlamydiosis anti-chlamydia immunity chlamydia persistence pathogenesis immunity Infectious and parasitic diseases RC109-216 A. N. Markina T. A. Kapustina O. V. Parilova E. V. Belova Pathogenic characteristics of intracellular infection in chlamydiosis
description	This review analyzes scientific data and systematized information regarding microbiological aspects and pathogenesis of chlamydia infection. Chlamydia are obligate intracellular microorganisms that are sensitive to any human cells where energy parasitism is possible: various types of epithelium, fibrocytes, histiocytes, glial and muscle cells, squamous epithelium of the meninges and eyeball, neurons, monocytes, macrophages. Structure, chemical composition and enzymatic activity of Chlamydia closely resemble those in Gram-negative bacteria, as they retain their morphological identity throughout the life cycle, possess cell wall, ribosomes, DNA, RNA, biochemical elements of glycolysis, tissue respiration, peptose production being sensitive to some broad-spectrum antibiotics, and are able to vegetative form division. In recent decades, the pathogenesis and clinical symptoms of chlamydial lesions in the urogenital tract, nervous, cardiovascular, musculoskeletal and bronchopulmonary systems have been actively studied, and new approaches and treatment schemes for chlamydia-infected patients are still developing. Over many decades, Chlamydia infection has been an important and urgent problem, not only due to its high prevalence, but also because of high rate of complications negatively affecting populational health and related demographic parameters. Chlamydia causes multiple diseases resulting in chronization of inflammatory process in all human organs and systems, and affects reproduction of population. Mandatory statistical recording of chlamydiosis cases introduced as early as in 1994 in the Russian Federation does not reflect the actual incidence rate. A rise in number of inflammatory diseases of the upper respiratory tract caused by Chlamydia undoubtedly increases its etiological importance, but data regarding etiopathogenetic role of Chlamydia in ENT pathology are ambiguous and contradictory. Available publications describe a large range of variation in rate of detected Chlamydia due to poor awareness of doctors about the microbiological properties of chlamydia, pathogenetic and clinical features of clinical signs of this infection, and lack of common and clear understanding on the algorithms for identifying and treating chlamydiosis. Since the majority of chlamydia-associated nosological forms are asymptomatic, knowing pathogenetic features of related will allow to prevent the spread of the infection and reduce subsequent socio-economic consequences.
format	article
author	A. N. Markina T. A. Kapustina O. V. Parilova E. V. Belova
author_facet	A. N. Markina T. A. Kapustina O. V. Parilova E. V. Belova
author_sort	A. N. Markina
title	Pathogenic characteristics of intracellular infection in chlamydiosis
title_short	Pathogenic characteristics of intracellular infection in chlamydiosis
title_full	Pathogenic characteristics of intracellular infection in chlamydiosis
title_fullStr	Pathogenic characteristics of intracellular infection in chlamydiosis
title_full_unstemmed	Pathogenic characteristics of intracellular infection in chlamydiosis
title_sort	pathogenic characteristics of intracellular infection in chlamydiosis
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2021
url	https://doaj.org/article/1a5b2947fbb84b1193150982bb486e4c
work_keys_str_mv	AT anmarkina pathogeniccharacteristicsofintracellularinfectioninchlamydiosis AT takapustina pathogeniccharacteristicsofintracellularinfectioninchlamydiosis AT ovparilova pathogeniccharacteristicsofintracellularinfectioninchlamydiosis AT evbelova pathogeniccharacteristicsofintracellularinfectioninchlamydiosis
_version_	1718417902154022912

Pathogenic characteristics of intracellular infection in chlamydiosis

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