Does dehydroepiandrosterone sulfate have a role in COVID-19 prognosis and treatment?

The pathophysiology of COVID comprises an exaggerated pro-inflammatory response. Hypothalamic-pituitary-adrenal (HPA) axis has a crucial role in various inflammatory conditions and modulated immunological response. Limited evidence is available regarding the incidence and the effect of HPA dysfuncti...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tomo Sojit, Banerjee Mithu, Sharma Praveen, Garg Mahendra
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2021
Materias:	covid-19 hypothalamic-pituitary-adrenal axis dhea dheas cortisol Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/1a5e720786f94662aada43f4fc6c2328
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1a5e720786f94662aada43f4fc6c2328
record_format	dspace
spelling	oai:doaj.org-article:1a5e720786f94662aada43f4fc6c23282021-12-02T19:03:59ZDoes dehydroepiandrosterone sulfate have a role in COVID-19 prognosis and treatment?1336-032910.2478/enr-2021-0019https://doaj.org/article/1a5e720786f94662aada43f4fc6c23282021-07-01T00:00:00Zhttps://doi.org/10.2478/enr-2021-0019https://doaj.org/toc/1336-0329The pathophysiology of COVID comprises an exaggerated pro-inflammatory response. Hypothalamic-pituitary-adrenal (HPA) axis has a crucial role in various inflammatory conditions and modulated immunological response. Limited evidence is available regarding the incidence and the effect of HPA dysfunction in COVID-19. Although the cortisol levels have only been estimated in a few studies, the dehydroepiandrosterone sulfate (DHEAS) release from the adrenal gland has not been explored yet. In this mini review, the authors discuss the role of dehydroepiandrosterone (DHEA) and DHEAS in the acute stress response and immunological modulation. Various effects of DHEAS have been demonstrated in different diseases. The specific inhibitory effect of DHEA on interleukin 6 (IL-6) could be of paramount importance in COVID-19. Further, DHEA supplementation has already been proposed in inflammatory conditions, like rheumatoid arthritis. DHEAS levels in COVID-19 may help to understand the HPA axis dysfunction as well as the possibility of repurposing DHEA as a drug for mitigating the pro-inflammatory COVID-19.Tomo SojitBanerjee MithuSharma PraveenGarg MahendraSciendoarticlecovid-19hypothalamic-pituitary-adrenal axisdheadheascortisolDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENEndocrine Regulations, Vol 55, Iss 3, Pp 174-181 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	covid-19 hypothalamic-pituitary-adrenal axis dhea dheas cortisol Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	covid-19 hypothalamic-pituitary-adrenal axis dhea dheas cortisol Diseases of the endocrine glands. Clinical endocrinology RC648-665 Tomo Sojit Banerjee Mithu Sharma Praveen Garg Mahendra Does dehydroepiandrosterone sulfate have a role in COVID-19 prognosis and treatment?
description	The pathophysiology of COVID comprises an exaggerated pro-inflammatory response. Hypothalamic-pituitary-adrenal (HPA) axis has a crucial role in various inflammatory conditions and modulated immunological response. Limited evidence is available regarding the incidence and the effect of HPA dysfunction in COVID-19. Although the cortisol levels have only been estimated in a few studies, the dehydroepiandrosterone sulfate (DHEAS) release from the adrenal gland has not been explored yet. In this mini review, the authors discuss the role of dehydroepiandrosterone (DHEA) and DHEAS in the acute stress response and immunological modulation. Various effects of DHEAS have been demonstrated in different diseases. The specific inhibitory effect of DHEA on interleukin 6 (IL-6) could be of paramount importance in COVID-19. Further, DHEA supplementation has already been proposed in inflammatory conditions, like rheumatoid arthritis. DHEAS levels in COVID-19 may help to understand the HPA axis dysfunction as well as the possibility of repurposing DHEA as a drug for mitigating the pro-inflammatory COVID-19.
format	article
author	Tomo Sojit Banerjee Mithu Sharma Praveen Garg Mahendra
author_facet	Tomo Sojit Banerjee Mithu Sharma Praveen Garg Mahendra
author_sort	Tomo Sojit
title	Does dehydroepiandrosterone sulfate have a role in COVID-19 prognosis and treatment?
title_short	Does dehydroepiandrosterone sulfate have a role in COVID-19 prognosis and treatment?
title_full	Does dehydroepiandrosterone sulfate have a role in COVID-19 prognosis and treatment?
title_fullStr	Does dehydroepiandrosterone sulfate have a role in COVID-19 prognosis and treatment?
title_full_unstemmed	Does dehydroepiandrosterone sulfate have a role in COVID-19 prognosis and treatment?
title_sort	does dehydroepiandrosterone sulfate have a role in covid-19 prognosis and treatment?
publisher	Sciendo
publishDate	2021
url	https://doaj.org/article/1a5e720786f94662aada43f4fc6c2328
work_keys_str_mv	AT tomosojit doesdehydroepiandrosteronesulfatehavearoleincovid19prognosisandtreatment AT banerjeemithu doesdehydroepiandrosteronesulfatehavearoleincovid19prognosisandtreatment AT sharmapraveen doesdehydroepiandrosteronesulfatehavearoleincovid19prognosisandtreatment AT gargmahendra doesdehydroepiandrosteronesulfatehavearoleincovid19prognosisandtreatment
_version_	1718377193875177472

Does dehydroepiandrosterone sulfate have a role in COVID-19 prognosis and treatment?

Ejemplares similares