Epidemiology and prognosis in young lung cancer patients aged under 45 years old in northern China

Abstract To explore the epidemiological characteristics and prognosis of lung cancer in patients aged under 45 years old in northern China. The population-based database about lung cancer cases aged under 45y selected form the Hebei Provincial Cancer Registry Center from 2010–2015. Mortality data of...

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Autores principales:	Jin Shi, Daojuan Li, Di Liang, Yutong He
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1a5eefef2ab842a8ba8747c9eac6e0f8
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spelling	oai:doaj.org-article:1a5eefef2ab842a8ba8747c9eac6e0f82021-12-02T13:24:14ZEpidemiology and prognosis in young lung cancer patients aged under 45 years old in northern China10.1038/s41598-021-86203-42045-2322https://doaj.org/article/1a5eefef2ab842a8ba8747c9eac6e0f82021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86203-4https://doaj.org/toc/2045-2322Abstract To explore the epidemiological characteristics and prognosis of lung cancer in patients aged under 45 years old in northern China. The population-based database about lung cancer cases aged under 45y selected form the Hebei Provincial Cancer Registry Center from 2010–2015. Mortality data of young death from 1973 to 1975, 1990 to 1992, and 2004 to 2005 were extracted from the national retrospective survey of death. Mortality rates were calculated by the mortality database above in this analysis. Consecutive, 954 non-selected younger patients (< 45 years) and 2261 selected older patients (≥ 45 years) with pathologically diagnosed lung cancer treated at the Fourth Hospital of Hebei Medical University were included as the hospital-based database. Epidemiological, treatment outcomes and prognosis status from 2010 to 2017 were documented. A comparison with younger and older patients was also made. Multivariate analysis with young lung cancer patients was calculated by Cox regression model. The younger lung cancer mortality rate tended to slightly increase in Hebei Province, from 1.04 per100 000 in 1973 to 2.01 per 100 000 in 2015, but the PDR tended to decrease over the last 40 years. There were 954 younger and 2261 older lung cancer patients included in the hospital-based database. The proportions of patients who were female (50.84% vs 34.85%), family history of cancer (12.37% vs 6.32%), advanced stage at diagnosis (65.46% vs 60.77%) and adenocarcinoma (65.27% vs 61.11%) were relatively higher in the younger group than in the older group. The median OS were 23.0 months and 27.0 months between younger and older, the OS difference existed between the two groups (P = 0.001). In the younger patients, Cox regression showed that a family history of cancer, symptoms at diagnosis, pathology, stage at diagnosis and surgery were confirmed as independent factors affecting the prognosis. Mortality rates among younger lung cancer patients showed an increasing trend in northern China. The younger account for small but have unique characteristics, with higher proportions of female, family history of cancer, adenocarcinoma and advanced stages than the older group and had a trend of worse OS.Jin ShiDaojuan LiDi LiangYutong HeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jin Shi Daojuan Li Di Liang Yutong He Epidemiology and prognosis in young lung cancer patients aged under 45 years old in northern China
description	Abstract To explore the epidemiological characteristics and prognosis of lung cancer in patients aged under 45 years old in northern China. The population-based database about lung cancer cases aged under 45y selected form the Hebei Provincial Cancer Registry Center from 2010–2015. Mortality data of young death from 1973 to 1975, 1990 to 1992, and 2004 to 2005 were extracted from the national retrospective survey of death. Mortality rates were calculated by the mortality database above in this analysis. Consecutive, 954 non-selected younger patients (< 45 years) and 2261 selected older patients (≥ 45 years) with pathologically diagnosed lung cancer treated at the Fourth Hospital of Hebei Medical University were included as the hospital-based database. Epidemiological, treatment outcomes and prognosis status from 2010 to 2017 were documented. A comparison with younger and older patients was also made. Multivariate analysis with young lung cancer patients was calculated by Cox regression model. The younger lung cancer mortality rate tended to slightly increase in Hebei Province, from 1.04 per100 000 in 1973 to 2.01 per 100 000 in 2015, but the PDR tended to decrease over the last 40 years. There were 954 younger and 2261 older lung cancer patients included in the hospital-based database. The proportions of patients who were female (50.84% vs 34.85%), family history of cancer (12.37% vs 6.32%), advanced stage at diagnosis (65.46% vs 60.77%) and adenocarcinoma (65.27% vs 61.11%) were relatively higher in the younger group than in the older group. The median OS were 23.0 months and 27.0 months between younger and older, the OS difference existed between the two groups (P = 0.001). In the younger patients, Cox regression showed that a family history of cancer, symptoms at diagnosis, pathology, stage at diagnosis and surgery were confirmed as independent factors affecting the prognosis. Mortality rates among younger lung cancer patients showed an increasing trend in northern China. The younger account for small but have unique characteristics, with higher proportions of female, family history of cancer, adenocarcinoma and advanced stages than the older group and had a trend of worse OS.
format	article
author	Jin Shi Daojuan Li Di Liang Yutong He
author_facet	Jin Shi Daojuan Li Di Liang Yutong He
author_sort	Jin Shi
title	Epidemiology and prognosis in young lung cancer patients aged under 45 years old in northern China
title_short	Epidemiology and prognosis in young lung cancer patients aged under 45 years old in northern China
title_full	Epidemiology and prognosis in young lung cancer patients aged under 45 years old in northern China
title_fullStr	Epidemiology and prognosis in young lung cancer patients aged under 45 years old in northern China
title_full_unstemmed	Epidemiology and prognosis in young lung cancer patients aged under 45 years old in northern China
title_sort	epidemiology and prognosis in young lung cancer patients aged under 45 years old in northern china
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1a5eefef2ab842a8ba8747c9eac6e0f8
work_keys_str_mv	AT jinshi epidemiologyandprognosisinyounglungcancerpatientsagedunder45yearsoldinnorthernchina AT daojuanli epidemiologyandprognosisinyounglungcancerpatientsagedunder45yearsoldinnorthernchina AT diliang epidemiologyandprognosisinyounglungcancerpatientsagedunder45yearsoldinnorthernchina AT yutonghe epidemiologyandprognosisinyounglungcancerpatientsagedunder45yearsoldinnorthernchina
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Epidemiology and prognosis in young lung cancer patients aged under 45 years old in northern China

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