A fluoride-responsive genetic circuit enables in vivo biofluorination in engineered Pseudomonas putida

Addition of fluorine to organic structures is a unique strategy for tuning molecular properties, but approaches to integrate fluorometabolites into the biochemistry of living cells are scarce. Here, the authors develop a fluoride-responsive genetic circuit to enable in vivo biofluorination in engine...

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Autores principales: Patricia Calero, Daniel C. Volke, Phillip T. Lowe, Charlotte H. Gotfredsen, David O’Hagan, Pablo I. Nikel
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/1a6013c572344c6f92fbaa1ff47e21f1
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Sumario:Addition of fluorine to organic structures is a unique strategy for tuning molecular properties, but approaches to integrate fluorometabolites into the biochemistry of living cells are scarce. Here, the authors develop a fluoride-responsive genetic circuit to enable in vivo biofluorination in engineered Pseudomonas putida.