A fluoride-responsive genetic circuit enables in vivo biofluorination in engineered Pseudomonas putida

Addition of fluorine to organic structures is a unique strategy for tuning molecular properties, but approaches to integrate fluorometabolites into the biochemistry of living cells are scarce. Here, the authors develop a fluoride-responsive genetic circuit to enable in vivo biofluorination in engine...

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Autores principales:	Patricia Calero, Daniel C. Volke, Phillip T. Lowe, Charlotte H. Gotfredsen, David O’Hagan, Pablo I. Nikel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1a6013c572344c6f92fbaa1ff47e21f1
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spelling	oai:doaj.org-article:1a6013c572344c6f92fbaa1ff47e21f12021-12-02T18:37:17ZA fluoride-responsive genetic circuit enables in vivo biofluorination in engineered Pseudomonas putida10.1038/s41467-020-18813-x2041-1723https://doaj.org/article/1a6013c572344c6f92fbaa1ff47e21f12020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18813-xhttps://doaj.org/toc/2041-1723Addition of fluorine to organic structures is a unique strategy for tuning molecular properties, but approaches to integrate fluorometabolites into the biochemistry of living cells are scarce. Here, the authors develop a fluoride-responsive genetic circuit to enable in vivo biofluorination in engineered Pseudomonas putida.Patricia CaleroDaniel C. VolkePhillip T. LoweCharlotte H. GotfredsenDavid O’HaganPablo I. NikelNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Patricia Calero Daniel C. Volke Phillip T. Lowe Charlotte H. Gotfredsen David O’Hagan Pablo I. Nikel A fluoride-responsive genetic circuit enables in vivo biofluorination in engineered Pseudomonas putida
description	Addition of fluorine to organic structures is a unique strategy for tuning molecular properties, but approaches to integrate fluorometabolites into the biochemistry of living cells are scarce. Here, the authors develop a fluoride-responsive genetic circuit to enable in vivo biofluorination in engineered Pseudomonas putida.
format	article
author	Patricia Calero Daniel C. Volke Phillip T. Lowe Charlotte H. Gotfredsen David O’Hagan Pablo I. Nikel
author_facet	Patricia Calero Daniel C. Volke Phillip T. Lowe Charlotte H. Gotfredsen David O’Hagan Pablo I. Nikel
author_sort	Patricia Calero
title	A fluoride-responsive genetic circuit enables in vivo biofluorination in engineered Pseudomonas putida
title_short	A fluoride-responsive genetic circuit enables in vivo biofluorination in engineered Pseudomonas putida
title_full	A fluoride-responsive genetic circuit enables in vivo biofluorination in engineered Pseudomonas putida
title_fullStr	A fluoride-responsive genetic circuit enables in vivo biofluorination in engineered Pseudomonas putida
title_full_unstemmed	A fluoride-responsive genetic circuit enables in vivo biofluorination in engineered Pseudomonas putida
title_sort	fluoride-responsive genetic circuit enables in vivo biofluorination in engineered pseudomonas putida
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1a6013c572344c6f92fbaa1ff47e21f1
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A fluoride-responsive genetic circuit enables in vivo biofluorination in engineered Pseudomonas putida

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