The therapeutic effects of adipose-derived mesenchymal stem cells on obesity and its associated diseases in diet-induced obese mice

Abstract Obesity is a global public health concern associated with increased risk of several comorbidities. Due to the limited effectiveness of current therapies, new treatment strategies are needed. Our aim was to examine the effect of adipose-derived mesenchymal stem cells (AD-MSCs) on obesity and...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hala jaber, Khodr Issa, Ali Eid, Fatima A. Saleh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1a62c90ccacf4fcb95d0c269778041b5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1a62c90ccacf4fcb95d0c269778041b5
record_format	dspace
spelling	oai:doaj.org-article:1a62c90ccacf4fcb95d0c269778041b52021-12-02T13:17:56ZThe therapeutic effects of adipose-derived mesenchymal stem cells on obesity and its associated diseases in diet-induced obese mice10.1038/s41598-021-85917-92045-2322https://doaj.org/article/1a62c90ccacf4fcb95d0c269778041b52021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85917-9https://doaj.org/toc/2045-2322Abstract Obesity is a global public health concern associated with increased risk of several comorbidities. Due to the limited effectiveness of current therapies, new treatment strategies are needed. Our aim was to examine the effect of adipose-derived mesenchymal stem cells (AD-MSCs) on obesity and its associated diseases in a diet-induced obese (DIO) animal model. C57BL6 mice were fed with either high fat diet (HFD) or CHOW diet for 15 weeks. Obese and lean mice were then subjected to two doses of AD-MSCs intraperitoneally. Mice body weight and composition; food intake; blood glucose levels; glycated hemoglobin (HbA1c), intraperitoneal glucose tolerance test and atherogenic index of plasma (AIP) were measured. Pro-inflammatory cytokines, tumor necrosis factor-α and interleukin-6, were also determined. AD-MSCs treatment reduced blood glucose levels, HbA1c and AIP as well as improved glucose tolerance in DIO mice. In addition, MSCs caused significant attenuation in the levels of inflammatory mediators in HFD-fed mice. Taken together, AD-MSCs were effective in treating obesity-associated diabetes in an animal model as well as protective against cardiovascular diseases as shown by AIP, which might be partly due to the attenuation of inflammatory mediators. Thus, AD-MSCs may offer a promising therapeutic potential in counteracting obesity-related diseases in patients.Hala jaberKhodr IssaAli EidFatima A. SalehNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hala jaber Khodr Issa Ali Eid Fatima A. Saleh The therapeutic effects of adipose-derived mesenchymal stem cells on obesity and its associated diseases in diet-induced obese mice
description	Abstract Obesity is a global public health concern associated with increased risk of several comorbidities. Due to the limited effectiveness of current therapies, new treatment strategies are needed. Our aim was to examine the effect of adipose-derived mesenchymal stem cells (AD-MSCs) on obesity and its associated diseases in a diet-induced obese (DIO) animal model. C57BL6 mice were fed with either high fat diet (HFD) or CHOW diet for 15 weeks. Obese and lean mice were then subjected to two doses of AD-MSCs intraperitoneally. Mice body weight and composition; food intake; blood glucose levels; glycated hemoglobin (HbA1c), intraperitoneal glucose tolerance test and atherogenic index of plasma (AIP) were measured. Pro-inflammatory cytokines, tumor necrosis factor-α and interleukin-6, were also determined. AD-MSCs treatment reduced blood glucose levels, HbA1c and AIP as well as improved glucose tolerance in DIO mice. In addition, MSCs caused significant attenuation in the levels of inflammatory mediators in HFD-fed mice. Taken together, AD-MSCs were effective in treating obesity-associated diabetes in an animal model as well as protective against cardiovascular diseases as shown by AIP, which might be partly due to the attenuation of inflammatory mediators. Thus, AD-MSCs may offer a promising therapeutic potential in counteracting obesity-related diseases in patients.
format	article
author	Hala jaber Khodr Issa Ali Eid Fatima A. Saleh
author_facet	Hala jaber Khodr Issa Ali Eid Fatima A. Saleh
author_sort	Hala jaber
title	The therapeutic effects of adipose-derived mesenchymal stem cells on obesity and its associated diseases in diet-induced obese mice
title_short	The therapeutic effects of adipose-derived mesenchymal stem cells on obesity and its associated diseases in diet-induced obese mice
title_full	The therapeutic effects of adipose-derived mesenchymal stem cells on obesity and its associated diseases in diet-induced obese mice
title_fullStr	The therapeutic effects of adipose-derived mesenchymal stem cells on obesity and its associated diseases in diet-induced obese mice
title_full_unstemmed	The therapeutic effects of adipose-derived mesenchymal stem cells on obesity and its associated diseases in diet-induced obese mice
title_sort	therapeutic effects of adipose-derived mesenchymal stem cells on obesity and its associated diseases in diet-induced obese mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1a62c90ccacf4fcb95d0c269778041b5
work_keys_str_mv	AT halajaber thetherapeuticeffectsofadiposederivedmesenchymalstemcellsonobesityanditsassociateddiseasesindietinducedobesemice AT khodrissa thetherapeuticeffectsofadiposederivedmesenchymalstemcellsonobesityanditsassociateddiseasesindietinducedobesemice AT alieid thetherapeuticeffectsofadiposederivedmesenchymalstemcellsonobesityanditsassociateddiseasesindietinducedobesemice AT fatimaasaleh thetherapeuticeffectsofadiposederivedmesenchymalstemcellsonobesityanditsassociateddiseasesindietinducedobesemice AT halajaber therapeuticeffectsofadiposederivedmesenchymalstemcellsonobesityanditsassociateddiseasesindietinducedobesemice AT khodrissa therapeuticeffectsofadiposederivedmesenchymalstemcellsonobesityanditsassociateddiseasesindietinducedobesemice AT alieid therapeuticeffectsofadiposederivedmesenchymalstemcellsonobesityanditsassociateddiseasesindietinducedobesemice AT fatimaasaleh therapeuticeffectsofadiposederivedmesenchymalstemcellsonobesityanditsassociateddiseasesindietinducedobesemice
_version_	1718393319107592192

The therapeutic effects of adipose-derived mesenchymal stem cells on obesity and its associated diseases in diet-induced obese mice

Ejemplares similares