HIV-1 subtype diversity and transmission strain source among men who have sex with men in Guangxi, China

Abstract With the rapid increase in HIV prevalence of men who have sex with men (MSM) in recent years and common human migration and travelling across different provinces in China, MSM are now finding it easier to meet each other, which might contribute to local HIV epidemics as well as fueling cros...

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Autores principales:	Yi Chen, Zhiyong Shen, Yi Feng, Yuhua Ruan, Jianjun Li, Shuai Tang, Kailing Tang, Shujia Liang, Xianwu Pang, Edward B. McNeil, Hui Xing, Virasakdi Chongsuvivatwong, Mei Lin, Guanghua Lan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1a62f932c0214c7c8179464736310d6e
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spelling	oai:doaj.org-article:1a62f932c0214c7c8179464736310d6e2021-12-02T18:03:31ZHIV-1 subtype diversity and transmission strain source among men who have sex with men in Guangxi, China10.1038/s41598-021-87745-32045-2322https://doaj.org/article/1a62f932c0214c7c8179464736310d6e2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87745-3https://doaj.org/toc/2045-2322Abstract With the rapid increase in HIV prevalence of men who have sex with men (MSM) in recent years and common human migration and travelling across different provinces in China, MSM are now finding it easier to meet each other, which might contribute to local HIV epidemics as well as fueling cross-province transmission. We performed a cross-sectional survey in 2018–2019 to investigate the current HIV subtype diversity and inferred HIV strain transmission origin among MSM in Guangxi province, China based on a phylogenetic analysis. Based on 238 samples, we found that the HIV-1 subtype diversity was more complicated than before, except for three major HIV subtypes/circulating recombinant forms (CRFs): CRF07_BC, CRF01_AE, CRF55_01B, five other subtypes/CRFs (CRF59_01B, B, CRF08_BC, CRF67_01B, CRF68_01B) and five unique recombinant forms (URFs) were detected. In total, 76.8% (169/220) of samples were infected with HIV from local circulating strains, while others originated from other provinces, predominantly Guangdong and Shanghai. The high diversity of HIV recombinants and complicated HIV transmission sources in Guangxi MSM indicates that there has been an active sexual network between HIV positive MSM both within and outside Guangxi without any effective prevention. Inter-province collaboration must be enforced to provide tailored HIV prevention and control services to MSM in China.Yi ChenZhiyong ShenYi FengYuhua RuanJianjun LiShuai TangKailing TangShujia LiangXianwu PangEdward B. McNeilHui XingVirasakdi ChongsuvivatwongMei LinGuanghua LanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yi Chen Zhiyong Shen Yi Feng Yuhua Ruan Jianjun Li Shuai Tang Kailing Tang Shujia Liang Xianwu Pang Edward B. McNeil Hui Xing Virasakdi Chongsuvivatwong Mei Lin Guanghua Lan HIV-1 subtype diversity and transmission strain source among men who have sex with men in Guangxi, China
description	Abstract With the rapid increase in HIV prevalence of men who have sex with men (MSM) in recent years and common human migration and travelling across different provinces in China, MSM are now finding it easier to meet each other, which might contribute to local HIV epidemics as well as fueling cross-province transmission. We performed a cross-sectional survey in 2018–2019 to investigate the current HIV subtype diversity and inferred HIV strain transmission origin among MSM in Guangxi province, China based on a phylogenetic analysis. Based on 238 samples, we found that the HIV-1 subtype diversity was more complicated than before, except for three major HIV subtypes/circulating recombinant forms (CRFs): CRF07_BC, CRF01_AE, CRF55_01B, five other subtypes/CRFs (CRF59_01B, B, CRF08_BC, CRF67_01B, CRF68_01B) and five unique recombinant forms (URFs) were detected. In total, 76.8% (169/220) of samples were infected with HIV from local circulating strains, while others originated from other provinces, predominantly Guangdong and Shanghai. The high diversity of HIV recombinants and complicated HIV transmission sources in Guangxi MSM indicates that there has been an active sexual network between HIV positive MSM both within and outside Guangxi without any effective prevention. Inter-province collaboration must be enforced to provide tailored HIV prevention and control services to MSM in China.
format	article
author	Yi Chen Zhiyong Shen Yi Feng Yuhua Ruan Jianjun Li Shuai Tang Kailing Tang Shujia Liang Xianwu Pang Edward B. McNeil Hui Xing Virasakdi Chongsuvivatwong Mei Lin Guanghua Lan
author_facet	Yi Chen Zhiyong Shen Yi Feng Yuhua Ruan Jianjun Li Shuai Tang Kailing Tang Shujia Liang Xianwu Pang Edward B. McNeil Hui Xing Virasakdi Chongsuvivatwong Mei Lin Guanghua Lan
author_sort	Yi Chen
title	HIV-1 subtype diversity and transmission strain source among men who have sex with men in Guangxi, China
title_short	HIV-1 subtype diversity and transmission strain source among men who have sex with men in Guangxi, China
title_full	HIV-1 subtype diversity and transmission strain source among men who have sex with men in Guangxi, China
title_fullStr	HIV-1 subtype diversity and transmission strain source among men who have sex with men in Guangxi, China
title_full_unstemmed	HIV-1 subtype diversity and transmission strain source among men who have sex with men in Guangxi, China
title_sort	hiv-1 subtype diversity and transmission strain source among men who have sex with men in guangxi, china
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1a62f932c0214c7c8179464736310d6e
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HIV-1 subtype diversity and transmission strain source among men who have sex with men in Guangxi, China

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