Effectiveness of convalescent plasma therapy in eight non-intubated coronavirus disease 2019 patients in Indonesia: a case series

Abstract Background Severe acute respiratory syndrome coronavirus 2, the cause of coronavirus disease 2019, has become a global pandemic. Currently, there is no definitive treatment for coronavirus disease 2019. Convalescent plasma therapy has become a potential specific curative method, while vacci...

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Autores principales:	Theresia Monica Rahardjo, Elizabeth Yogipranata, Ardian Hediyanto Naswan, Fitri Rahayu Sari, Fajar Budiono, Hernawati Permatasari, C. H. R. Driantik Chuntari
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Convalescent plasma therapy Non-intubated Case series Medicine R
Acceso en línea:	https://doaj.org/article/1a6494ccfcd14080824863834f0d10a8
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spelling	oai:doaj.org-article:1a6494ccfcd14080824863834f0d10a82021-11-28T12:37:15ZEffectiveness of convalescent plasma therapy in eight non-intubated coronavirus disease 2019 patients in Indonesia: a case series10.1186/s13256-021-03059-y1752-1947https://doaj.org/article/1a6494ccfcd14080824863834f0d10a82021-11-01T00:00:00Zhttps://doi.org/10.1186/s13256-021-03059-yhttps://doaj.org/toc/1752-1947Abstract Background Severe acute respiratory syndrome coronavirus 2, the cause of coronavirus disease 2019, has become a global pandemic. Currently, there is no definitive treatment for coronavirus disease 2019. Convalescent plasma therapy has become a potential specific curative method, while vaccines as protection modalities require further work. Case presentation Eight non-intubated Indonesian patients, ages ranging from 40 to 74 years old, with coronavirus disease 2019 confirmed by viral Ribonucleid Acid (RNA) real-time polymerase chain reaction tests were included. Four patients were administered two doses of 200 mL convalescent plasma, and the other four patients were administered one dose of convalescent plasma with an antibody titer of 1:320, within the first 14 days since symptoms occurred. The median times from illness onset to convalescent plasma therapy and from the first day of hospital admission to convalescent plasma therapy were 13 and 6.5 days, respectively. All patients showed improvements in clinical symptoms, laboratory parameters, thorax imaging, negative conversion of polymerase chain reaction results, and decreased oxygen supplementation within 1 week after convalescent plasma therapy. Patients with two convalescent plasma doses tended to have faster recovery than those with one convalescent plasma dose. No severe adverse effects were observed in any patient. Conclusion This is the first case series in Indonesia showing that convalescent plasma therapy is safe and well tolerated and that early convalescent plasma therapy before the patient is intubated could potentially prevent disease progression, increase the recovery rate, and shorten the inpatient time of stay.Theresia Monica RahardjoElizabeth YogipranataArdian Hediyanto NaswanFitri Rahayu SariFajar BudionoHernawati PermatasariC. H. R. Driantik ChuntariBMCarticleConvalescent plasma therapyNon-intubatedCase seriesMedicineRENJournal of Medical Case Reports, Vol 15, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Convalescent plasma therapy Non-intubated Case series Medicine R
spellingShingle	Convalescent plasma therapy Non-intubated Case series Medicine R Theresia Monica Rahardjo Elizabeth Yogipranata Ardian Hediyanto Naswan Fitri Rahayu Sari Fajar Budiono Hernawati Permatasari C. H. R. Driantik Chuntari Effectiveness of convalescent plasma therapy in eight non-intubated coronavirus disease 2019 patients in Indonesia: a case series
description	Abstract Background Severe acute respiratory syndrome coronavirus 2, the cause of coronavirus disease 2019, has become a global pandemic. Currently, there is no definitive treatment for coronavirus disease 2019. Convalescent plasma therapy has become a potential specific curative method, while vaccines as protection modalities require further work. Case presentation Eight non-intubated Indonesian patients, ages ranging from 40 to 74 years old, with coronavirus disease 2019 confirmed by viral Ribonucleid Acid (RNA) real-time polymerase chain reaction tests were included. Four patients were administered two doses of 200 mL convalescent plasma, and the other four patients were administered one dose of convalescent plasma with an antibody titer of 1:320, within the first 14 days since symptoms occurred. The median times from illness onset to convalescent plasma therapy and from the first day of hospital admission to convalescent plasma therapy were 13 and 6.5 days, respectively. All patients showed improvements in clinical symptoms, laboratory parameters, thorax imaging, negative conversion of polymerase chain reaction results, and decreased oxygen supplementation within 1 week after convalescent plasma therapy. Patients with two convalescent plasma doses tended to have faster recovery than those with one convalescent plasma dose. No severe adverse effects were observed in any patient. Conclusion This is the first case series in Indonesia showing that convalescent plasma therapy is safe and well tolerated and that early convalescent plasma therapy before the patient is intubated could potentially prevent disease progression, increase the recovery rate, and shorten the inpatient time of stay.
format	article
author	Theresia Monica Rahardjo Elizabeth Yogipranata Ardian Hediyanto Naswan Fitri Rahayu Sari Fajar Budiono Hernawati Permatasari C. H. R. Driantik Chuntari
author_facet	Theresia Monica Rahardjo Elizabeth Yogipranata Ardian Hediyanto Naswan Fitri Rahayu Sari Fajar Budiono Hernawati Permatasari C. H. R. Driantik Chuntari
author_sort	Theresia Monica Rahardjo
title	Effectiveness of convalescent plasma therapy in eight non-intubated coronavirus disease 2019 patients in Indonesia: a case series
title_short	Effectiveness of convalescent plasma therapy in eight non-intubated coronavirus disease 2019 patients in Indonesia: a case series
title_full	Effectiveness of convalescent plasma therapy in eight non-intubated coronavirus disease 2019 patients in Indonesia: a case series
title_fullStr	Effectiveness of convalescent plasma therapy in eight non-intubated coronavirus disease 2019 patients in Indonesia: a case series
title_full_unstemmed	Effectiveness of convalescent plasma therapy in eight non-intubated coronavirus disease 2019 patients in Indonesia: a case series
title_sort	effectiveness of convalescent plasma therapy in eight non-intubated coronavirus disease 2019 patients in indonesia: a case series
publisher	BMC
publishDate	2021
url	https://doaj.org/article/1a6494ccfcd14080824863834f0d10a8
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Effectiveness of convalescent plasma therapy in eight non-intubated coronavirus disease 2019 patients in Indonesia: a case series

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