Effects of four kinds of electromagnetic fields (EMF) with different frequency spectrum bands on ovariectomized osteoporosis in mice

Effects of four kinds of electromagnetic fields (EMF) with different frequency spectrum bands on ovariectomized osteoporosis in mice

Abstract Electromagnetic fields (EMF) was considered as a non-invasive modality for treatment of osteoporosis while the effects were diverse with EMF parameters in time domain. In present study, we extended analysis of EMF characteristics from time domain to frequency domain, aiming to investigate e...

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Autores principales: Tao Lei, Feijiang Li, Zhuowen Liang, Chi Tang, Kangning Xie, Pan Wang, Xu Dong, Shuai Shan, Juan Liu, Qiaoling Xu, Erping Luo, Guanghao Shen
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Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/1a70d2ff10c143daa2ad0580b53f4324
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spelling oai:doaj.org-article:1a70d2ff10c143daa2ad0580b53f43242021-12-02T12:32:27ZEffects of four kinds of electromagnetic fields (EMF) with different frequency spectrum bands on ovariectomized osteoporosis in mice10.1038/s41598-017-00668-w2045-2322https://doaj.org/article/1a70d2ff10c143daa2ad0580b53f43242017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00668-whttps://doaj.org/toc/2045-2322Abstract Electromagnetic fields (EMF) was considered as a non-invasive modality for treatment of osteoporosis while the effects were diverse with EMF parameters in time domain. In present study, we extended analysis of EMF characteristics from time domain to frequency domain, aiming to investigate effects of four kinds of EMF (LP (1–100 Hz), BP (100–3,000 Hz), HP (3,000–50,000 Hz) and AP (1–50,000 Hz)) on ovariectomized (OVX) osteoporosis (OP) in mice. Forty-eight 3-month-old female BALB/c mice were equally assigned to Sham, OVX, OVX + LP, OVX + BP, OVX + HP and OVX + AP groups (n = 8). After 8-week exposure (3 h/day), LP and BP significantly increased serum bone formation markers and osteogenesis-related gene expressions compared with OVX. Bedsides, LP and BP also slightly increased bone resorption activity compared with OVX, evidenced by increased RANKL/OPG ratio. HP sharply decreased serum bone formation and resporption markers and osteogenesis and osteoclastogenesis related gene expressions compared with OVX. AP had accumulative effects of LP, BP and HP, which significantly increased bone formation and decreased bone resporption activity compared with OVX. As a result, LP, BP and HP exposure did not later deterioration of bone mass, microarchitecture and mechanical strength in OVX mice with OP. However, AP stimulation attenuated OVX-induced bone loss.Tao LeiFeijiang LiZhuowen LiangChi TangKangning XiePan WangXu DongShuai ShanJuan LiuQiaoling XuErping LuoGuanghao ShenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Tao Lei
Feijiang Li
Zhuowen Liang
Chi Tang
Kangning Xie
Pan Wang
Xu Dong
Shuai Shan
Juan Liu
Qiaoling Xu
Erping Luo
Guanghao Shen
Effects of four kinds of electromagnetic fields (EMF) with different frequency spectrum bands on ovariectomized osteoporosis in mice
description Abstract Electromagnetic fields (EMF) was considered as a non-invasive modality for treatment of osteoporosis while the effects were diverse with EMF parameters in time domain. In present study, we extended analysis of EMF characteristics from time domain to frequency domain, aiming to investigate effects of four kinds of EMF (LP (1–100 Hz), BP (100–3,000 Hz), HP (3,000–50,000 Hz) and AP (1–50,000 Hz)) on ovariectomized (OVX) osteoporosis (OP) in mice. Forty-eight 3-month-old female BALB/c mice were equally assigned to Sham, OVX, OVX + LP, OVX + BP, OVX + HP and OVX + AP groups (n = 8). After 8-week exposure (3 h/day), LP and BP significantly increased serum bone formation markers and osteogenesis-related gene expressions compared with OVX. Bedsides, LP and BP also slightly increased bone resorption activity compared with OVX, evidenced by increased RANKL/OPG ratio. HP sharply decreased serum bone formation and resporption markers and osteogenesis and osteoclastogenesis related gene expressions compared with OVX. AP had accumulative effects of LP, BP and HP, which significantly increased bone formation and decreased bone resporption activity compared with OVX. As a result, LP, BP and HP exposure did not later deterioration of bone mass, microarchitecture and mechanical strength in OVX mice with OP. However, AP stimulation attenuated OVX-induced bone loss.
format article
author Tao Lei
Feijiang Li
Zhuowen Liang
Chi Tang
Kangning Xie
Pan Wang
Xu Dong
Shuai Shan
Juan Liu
Qiaoling Xu
Erping Luo
Guanghao Shen
author_facet Tao Lei
Feijiang Li
Zhuowen Liang
Chi Tang
Kangning Xie
Pan Wang
Xu Dong
Shuai Shan
Juan Liu
Qiaoling Xu
Erping Luo
Guanghao Shen
author_sort Tao Lei
title Effects of four kinds of electromagnetic fields (EMF) with different frequency spectrum bands on ovariectomized osteoporosis in mice
title_short Effects of four kinds of electromagnetic fields (EMF) with different frequency spectrum bands on ovariectomized osteoporosis in mice
title_full Effects of four kinds of electromagnetic fields (EMF) with different frequency spectrum bands on ovariectomized osteoporosis in mice
title_fullStr Effects of four kinds of electromagnetic fields (EMF) with different frequency spectrum bands on ovariectomized osteoporosis in mice
title_full_unstemmed Effects of four kinds of electromagnetic fields (EMF) with different frequency spectrum bands on ovariectomized osteoporosis in mice
title_sort effects of four kinds of electromagnetic fields (emf) with different frequency spectrum bands on ovariectomized osteoporosis in mice
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/1a70d2ff10c143daa2ad0580b53f4324
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