Comparison of Protectivity and Safety of Two Vaccines against <i>Actinobacillus pleuropneumoniae</i> in a Field Study

<i>Actinobacillus pleuropneumoniae</i> causing porcine pleuropneumoniae is responsible for lowered productivity and reduction of performance indicators such as daily weight gain and increase of losses in the swine industry worldwide. To control the disease, vaccination is used to reduce...

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Autores principales:	Peter Hölzen, Tobias Warnck, Steffen Hoy, Kathleen Schlegel, Isabel Hennig-Pauka, Horst Gaumann
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Actinobacillus pleuropneumoniae</i> porcine pleuropneumoniae PP Coglapix Apx LPS Agriculture (General) S1-972
Acceso en línea:	https://doaj.org/article/1a718abeca4649ddbf2e33245fecfc8b
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spelling	oai:doaj.org-article:1a718abeca4649ddbf2e33245fecfc8b2021-11-25T16:00:31ZComparison of Protectivity and Safety of Two Vaccines against <i>Actinobacillus pleuropneumoniae</i> in a Field Study10.3390/agriculture111111432077-0472https://doaj.org/article/1a718abeca4649ddbf2e33245fecfc8b2021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0472/11/11/1143https://doaj.org/toc/2077-0472<i>Actinobacillus pleuropneumoniae</i> causing porcine pleuropneumoniae is responsible for lowered productivity and reduction of performance indicators such as daily weight gain and increase of losses in the swine industry worldwide. To control the disease, vaccination is used to reduce clinical signs and production losses. A randomized, blinded field trail was conducted to compare two licensed <i>A. pleuropneumoniae</i> vaccines in 600 finishing pigs in terms of lung lesions, mortality, medication, weight gain and safety, in a farm in northeast Germany. After weaning, pigs were allocated randomly in two groups resulting in group sizes of 300 individuals. Nursery pigs were vaccinated at the age of 7 to 10 weeks either with a <i>A. pleuropneumoniae</i> bacterin, containing ApxI-III toxoids (group 1), or with a subunit purified <i>A. pleuropneumoniae</i> toxoid vaccine (group 2). Blinded lung lesion scoring at slaughter following the Ceva Lung Program methodology revealed a significantly lower proportion of lungs affected with pleurisy in group 1 compared to group 2. Weighing of the animals did not show a significant difference (<i>p</i> = 0.092); however, at the end of finishing animals of group 1 showed a 1.59 kg higher weight (100.40 ± 10.15 kg) compared to animals in group 2 (98.81 kg ± 11.56 kg). Mortality and antimicrobial medication were significantly lower in group 1 compared to group 2 (13 losses and 17 antimicrobial medications in group 2, 4 losses and 1 antimicrobial medications in group 1). Injection site and systemic adverse reactions were recorded on both days of vaccination and did not differ significantly between the groups (<i>p</i> > 0.05). In this study, the efficacy of vaccination with a commercially available <i>A. pleuropneumoniae</i> bacterin containing ApxI-III toxoids was superior to that of a commercially available <i>A. pleuropneumoniae</i> subunit toxoid vaccine in preventing pulmonary lesions associated with <i>A. pleuropneumoniae</i> infection.Grzegorz WoźniakowskiPeter HölzenTobias WarnckSteffen HoyKathleen SchlegelIsabel Hennig-PaukaHorst GaumannMDPI AGarticle<i>Actinobacillus pleuropneumoniae</i>porcine pleuropneumoniaePPCoglapixApxLPSAgriculture (General)S1-972ENAgriculture, Vol 11, Iss 1143, p 1143 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Actinobacillus pleuropneumoniae</i> porcine pleuropneumoniae PP Coglapix Apx LPS Agriculture (General) S1-972
spellingShingle	<i>Actinobacillus pleuropneumoniae</i> porcine pleuropneumoniae PP Coglapix Apx LPS Agriculture (General) S1-972 Peter Hölzen Tobias Warnck Steffen Hoy Kathleen Schlegel Isabel Hennig-Pauka Horst Gaumann Comparison of Protectivity and Safety of Two Vaccines against <i>Actinobacillus pleuropneumoniae</i> in a Field Study
description	<i>Actinobacillus pleuropneumoniae</i> causing porcine pleuropneumoniae is responsible for lowered productivity and reduction of performance indicators such as daily weight gain and increase of losses in the swine industry worldwide. To control the disease, vaccination is used to reduce clinical signs and production losses. A randomized, blinded field trail was conducted to compare two licensed <i>A. pleuropneumoniae</i> vaccines in 600 finishing pigs in terms of lung lesions, mortality, medication, weight gain and safety, in a farm in northeast Germany. After weaning, pigs were allocated randomly in two groups resulting in group sizes of 300 individuals. Nursery pigs were vaccinated at the age of 7 to 10 weeks either with a <i>A. pleuropneumoniae</i> bacterin, containing ApxI-III toxoids (group 1), or with a subunit purified <i>A. pleuropneumoniae</i> toxoid vaccine (group 2). Blinded lung lesion scoring at slaughter following the Ceva Lung Program methodology revealed a significantly lower proportion of lungs affected with pleurisy in group 1 compared to group 2. Weighing of the animals did not show a significant difference (<i>p</i> = 0.092); however, at the end of finishing animals of group 1 showed a 1.59 kg higher weight (100.40 ± 10.15 kg) compared to animals in group 2 (98.81 kg ± 11.56 kg). Mortality and antimicrobial medication were significantly lower in group 1 compared to group 2 (13 losses and 17 antimicrobial medications in group 2, 4 losses and 1 antimicrobial medications in group 1). Injection site and systemic adverse reactions were recorded on both days of vaccination and did not differ significantly between the groups (<i>p</i> > 0.05). In this study, the efficacy of vaccination with a commercially available <i>A. pleuropneumoniae</i> bacterin containing ApxI-III toxoids was superior to that of a commercially available <i>A. pleuropneumoniae</i> subunit toxoid vaccine in preventing pulmonary lesions associated with <i>A. pleuropneumoniae</i> infection.Grzegorz Woźniakowski
format	article
author	Peter Hölzen Tobias Warnck Steffen Hoy Kathleen Schlegel Isabel Hennig-Pauka Horst Gaumann
author_facet	Peter Hölzen Tobias Warnck Steffen Hoy Kathleen Schlegel Isabel Hennig-Pauka Horst Gaumann
author_sort	Peter Hölzen
title	Comparison of Protectivity and Safety of Two Vaccines against <i>Actinobacillus pleuropneumoniae</i> in a Field Study
title_short	Comparison of Protectivity and Safety of Two Vaccines against <i>Actinobacillus pleuropneumoniae</i> in a Field Study
title_full	Comparison of Protectivity and Safety of Two Vaccines against <i>Actinobacillus pleuropneumoniae</i> in a Field Study
title_fullStr	Comparison of Protectivity and Safety of Two Vaccines against <i>Actinobacillus pleuropneumoniae</i> in a Field Study
title_full_unstemmed	Comparison of Protectivity and Safety of Two Vaccines against <i>Actinobacillus pleuropneumoniae</i> in a Field Study
title_sort	comparison of protectivity and safety of two vaccines against <i>actinobacillus pleuropneumoniae</i> in a field study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1a718abeca4649ddbf2e33245fecfc8b
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Comparison of Protectivity and Safety of Two Vaccines against <i>Actinobacillus pleuropneumoniae</i> in a Field Study

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