Role of ICAM-1 in impaired retinal circulation in rhegmatogenous retinal detachment

Abstract Many studies have demonstrated that rhegmatogenous retinal detachment (RRD) leads to impaired retinal circulation. However, the involvement of inflammation in the RRD-induced worsening of retinal circulation was obscure. This retrospective observational study included 150 patients with prim...

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Autores principales:	Harumasa Yokota, Taiji Nagaoka, Hidetaka Noma, Akemi Ofusa, Tomoe Kanemaki, Hiroshi Aso, Hirotsugu Hanazaki, Satoru Yamagami, Masahiko Shimura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1a73750d402d4deb92dbb78a2a386bae
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spelling	oai:doaj.org-article:1a73750d402d4deb92dbb78a2a386bae2021-12-02T16:23:42ZRole of ICAM-1 in impaired retinal circulation in rhegmatogenous retinal detachment10.1038/s41598-021-94993-w2045-2322https://doaj.org/article/1a73750d402d4deb92dbb78a2a386bae2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94993-whttps://doaj.org/toc/2045-2322Abstract Many studies have demonstrated that rhegmatogenous retinal detachment (RRD) leads to impaired retinal circulation. However, the involvement of inflammation in the RRD-induced worsening of retinal circulation was obscure. This retrospective observational study included 150 patients with primary RRD (macula-on, n = 63; macula-off, n = 87) who underwent 25-gauge microincision vitrectomy surgery (25G MIVS). Total retinal blood flow was represented by the mean blur rate (MBR) of the optic nerve head vessel, measured by laser speckle flowgraphy preoperatively and until 6 months postoperatively. Aqueous humor samples were obtained during surgery to determine cytokine concentrations by enzyme-linked immunosorbent assay. At 3 and 6 months postoperatively, there were no significant differences between eyes with macula-on RRD and fellow eyes. However, in macula-off RRD, MBR remained significantly lower in RRD eyes 6 months postoperatively (P < 0.05). Log-transformed levels of soluble intercellular adhesion molecule-1 (sICAM-1) were negatively correlated with relative MBR (r-MBR, RRD eye/fellow eye) before surgery (r = − 0.47, P = 0.01) in macula-on, but not macula-off, RRD. Six months postoperatively, r-MBR correlated significantly with sICAM-1 levels (r = − 0.36, P = 0.02) in macula-off RRD. ICAM-1 may play a role in RRD-induced deterioration of retinal circulation.Harumasa YokotaTaiji NagaokaHidetaka NomaAkemi OfusaTomoe KanemakiHiroshi AsoHirotsugu HanazakiSatoru YamagamiMasahiko ShimuraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Harumasa Yokota Taiji Nagaoka Hidetaka Noma Akemi Ofusa Tomoe Kanemaki Hiroshi Aso Hirotsugu Hanazaki Satoru Yamagami Masahiko Shimura Role of ICAM-1 in impaired retinal circulation in rhegmatogenous retinal detachment
description	Abstract Many studies have demonstrated that rhegmatogenous retinal detachment (RRD) leads to impaired retinal circulation. However, the involvement of inflammation in the RRD-induced worsening of retinal circulation was obscure. This retrospective observational study included 150 patients with primary RRD (macula-on, n = 63; macula-off, n = 87) who underwent 25-gauge microincision vitrectomy surgery (25G MIVS). Total retinal blood flow was represented by the mean blur rate (MBR) of the optic nerve head vessel, measured by laser speckle flowgraphy preoperatively and until 6 months postoperatively. Aqueous humor samples were obtained during surgery to determine cytokine concentrations by enzyme-linked immunosorbent assay. At 3 and 6 months postoperatively, there were no significant differences between eyes with macula-on RRD and fellow eyes. However, in macula-off RRD, MBR remained significantly lower in RRD eyes 6 months postoperatively (P < 0.05). Log-transformed levels of soluble intercellular adhesion molecule-1 (sICAM-1) were negatively correlated with relative MBR (r-MBR, RRD eye/fellow eye) before surgery (r = − 0.47, P = 0.01) in macula-on, but not macula-off, RRD. Six months postoperatively, r-MBR correlated significantly with sICAM-1 levels (r = − 0.36, P = 0.02) in macula-off RRD. ICAM-1 may play a role in RRD-induced deterioration of retinal circulation.
format	article
author	Harumasa Yokota Taiji Nagaoka Hidetaka Noma Akemi Ofusa Tomoe Kanemaki Hiroshi Aso Hirotsugu Hanazaki Satoru Yamagami Masahiko Shimura
author_facet	Harumasa Yokota Taiji Nagaoka Hidetaka Noma Akemi Ofusa Tomoe Kanemaki Hiroshi Aso Hirotsugu Hanazaki Satoru Yamagami Masahiko Shimura
author_sort	Harumasa Yokota
title	Role of ICAM-1 in impaired retinal circulation in rhegmatogenous retinal detachment
title_short	Role of ICAM-1 in impaired retinal circulation in rhegmatogenous retinal detachment
title_full	Role of ICAM-1 in impaired retinal circulation in rhegmatogenous retinal detachment
title_fullStr	Role of ICAM-1 in impaired retinal circulation in rhegmatogenous retinal detachment
title_full_unstemmed	Role of ICAM-1 in impaired retinal circulation in rhegmatogenous retinal detachment
title_sort	role of icam-1 in impaired retinal circulation in rhegmatogenous retinal detachment
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1a73750d402d4deb92dbb78a2a386bae
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Role of ICAM-1 in impaired retinal circulation in rhegmatogenous retinal detachment

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