Identification of cancer sex-disparity in the functional integrity of p53 and its X chromosome network

There is disproportionally high cancer prevalence in males. Here, the authors analyse the tumour suppressor p53 in sporadic cancers, highlighting a higher incidence of its mutation in males. Males are further disadvantaged by a failure to shield against the expression of damaged X-linked genes in p5...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sue Haupt, Franco Caramia, Alan Herschtal, Thierry Soussi, Guillermina Lozano, Hu Chen, Han Liang, Terence P. Speed, Ygal Haupt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1a749f75f57f428ea7b81ae7e79a67f1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1a749f75f57f428ea7b81ae7e79a67f1
record_format	dspace
spelling	oai:doaj.org-article:1a749f75f57f428ea7b81ae7e79a67f12021-12-02T14:39:39ZIdentification of cancer sex-disparity in the functional integrity of p53 and its X chromosome network10.1038/s41467-019-13266-32041-1723https://doaj.org/article/1a749f75f57f428ea7b81ae7e79a67f12019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13266-3https://doaj.org/toc/2041-1723There is disproportionally high cancer prevalence in males. Here, the authors analyse the tumour suppressor p53 in sporadic cancers, highlighting a higher incidence of its mutation in males. Males are further disadvantaged by a failure to shield against the expression of damaged X-linked genes in p53-networks. These factors likely contribute to sex-disparity.Sue HauptFranco CaramiaAlan HerschtalThierry SoussiGuillermina LozanoHu ChenHan LiangTerence P. SpeedYgal HauptNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sue Haupt Franco Caramia Alan Herschtal Thierry Soussi Guillermina Lozano Hu Chen Han Liang Terence P. Speed Ygal Haupt Identification of cancer sex-disparity in the functional integrity of p53 and its X chromosome network
description	There is disproportionally high cancer prevalence in males. Here, the authors analyse the tumour suppressor p53 in sporadic cancers, highlighting a higher incidence of its mutation in males. Males are further disadvantaged by a failure to shield against the expression of damaged X-linked genes in p53-networks. These factors likely contribute to sex-disparity.
format	article
author	Sue Haupt Franco Caramia Alan Herschtal Thierry Soussi Guillermina Lozano Hu Chen Han Liang Terence P. Speed Ygal Haupt
author_facet	Sue Haupt Franco Caramia Alan Herschtal Thierry Soussi Guillermina Lozano Hu Chen Han Liang Terence P. Speed Ygal Haupt
author_sort	Sue Haupt
title	Identification of cancer sex-disparity in the functional integrity of p53 and its X chromosome network
title_short	Identification of cancer sex-disparity in the functional integrity of p53 and its X chromosome network
title_full	Identification of cancer sex-disparity in the functional integrity of p53 and its X chromosome network
title_fullStr	Identification of cancer sex-disparity in the functional integrity of p53 and its X chromosome network
title_full_unstemmed	Identification of cancer sex-disparity in the functional integrity of p53 and its X chromosome network
title_sort	identification of cancer sex-disparity in the functional integrity of p53 and its x chromosome network
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/1a749f75f57f428ea7b81ae7e79a67f1
work_keys_str_mv	AT suehaupt identificationofcancersexdisparityinthefunctionalintegrityofp53anditsxchromosomenetwork AT francocaramia identificationofcancersexdisparityinthefunctionalintegrityofp53anditsxchromosomenetwork AT alanherschtal identificationofcancersexdisparityinthefunctionalintegrityofp53anditsxchromosomenetwork AT thierrysoussi identificationofcancersexdisparityinthefunctionalintegrityofp53anditsxchromosomenetwork AT guillerminalozano identificationofcancersexdisparityinthefunctionalintegrityofp53anditsxchromosomenetwork AT huchen identificationofcancersexdisparityinthefunctionalintegrityofp53anditsxchromosomenetwork AT hanliang identificationofcancersexdisparityinthefunctionalintegrityofp53anditsxchromosomenetwork AT terencepspeed identificationofcancersexdisparityinthefunctionalintegrityofp53anditsxchromosomenetwork AT ygalhaupt identificationofcancersexdisparityinthefunctionalintegrityofp53anditsxchromosomenetwork
_version_	1718390519569055744

Identification of cancer sex-disparity in the functional integrity of p53 and its X chromosome network

Ejemplares similares