Inner and outer retinal layer thickness alterations in pediatric and juvenile craniopharyngioma

Abstract We evaluated postoperative retinal thickness in pediatric and juvenile craniopharyngioma (CP) patients with chiasmal compression using optical coherence tomography (OCT) auto-segmentation. We included 18 eyes of 18 pediatric or juvenile patients with CP and 20 healthy controls. Each thickne...

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Autores principales:	Ga-In Lee, Kyung-Ah Park, Sei Yeul Oh, Doo-Sik Kong, Sang Duk Hong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1a765657aa264380a8d94d5b2ed1ad9a
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spelling	oai:doaj.org-article:1a765657aa264380a8d94d5b2ed1ad9a2021-12-02T14:06:31ZInner and outer retinal layer thickness alterations in pediatric and juvenile craniopharyngioma10.1038/s41598-021-82107-52045-2322https://doaj.org/article/1a765657aa264380a8d94d5b2ed1ad9a2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82107-5https://doaj.org/toc/2045-2322Abstract We evaluated postoperative retinal thickness in pediatric and juvenile craniopharyngioma (CP) patients with chiasmal compression using optical coherence tomography (OCT) auto-segmentation. We included 18 eyes of 18 pediatric or juvenile patients with CP and 20 healthy controls. Each thickness of the macular retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer, outer plexiform layer, outer nuclear layer, and photoreceptor layer was compared between the CP patients and healthy controls. There was significant thinning in the macular RNFL (estimates [μm], superior, − 10.68; inferior, − 7.24; nasal, − 14.22), all quadrants of GCL (superior, − 16.53; inferior, − 14.37; nasal, − 24.34; temporal, − 9.91) and IPL (superior, − 11.45; inferior, − 9.76; nasal, − 15.25; temporal, − 4.97) in pediatric and juvenile CP patients postoperatively compared to healthy control eyes after adjusting for age and refractive errors. Thickness reduction in the average and nasal quadrant of RNFL, GCL, and IPL was associated with peripapillary RNFL thickness, and reduced nasal quadrant GCL and IPL thicknesses were associated with postoperative visual field defects. In pediatric and juvenile patients with CP, decreased inner retinal layer thickness following chiasmal compression was observed. The changes in retinal structures were closely related to peripapillary RNFL thinning and functional outcomes.Ga-In LeeKyung-Ah ParkSei Yeul OhDoo-Sik KongSang Duk HongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ga-In Lee Kyung-Ah Park Sei Yeul Oh Doo-Sik Kong Sang Duk Hong Inner and outer retinal layer thickness alterations in pediatric and juvenile craniopharyngioma
description	Abstract We evaluated postoperative retinal thickness in pediatric and juvenile craniopharyngioma (CP) patients with chiasmal compression using optical coherence tomography (OCT) auto-segmentation. We included 18 eyes of 18 pediatric or juvenile patients with CP and 20 healthy controls. Each thickness of the macular retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer, outer plexiform layer, outer nuclear layer, and photoreceptor layer was compared between the CP patients and healthy controls. There was significant thinning in the macular RNFL (estimates [μm], superior, − 10.68; inferior, − 7.24; nasal, − 14.22), all quadrants of GCL (superior, − 16.53; inferior, − 14.37; nasal, − 24.34; temporal, − 9.91) and IPL (superior, − 11.45; inferior, − 9.76; nasal, − 15.25; temporal, − 4.97) in pediatric and juvenile CP patients postoperatively compared to healthy control eyes after adjusting for age and refractive errors. Thickness reduction in the average and nasal quadrant of RNFL, GCL, and IPL was associated with peripapillary RNFL thickness, and reduced nasal quadrant GCL and IPL thicknesses were associated with postoperative visual field defects. In pediatric and juvenile patients with CP, decreased inner retinal layer thickness following chiasmal compression was observed. The changes in retinal structures were closely related to peripapillary RNFL thinning and functional outcomes.
format	article
author	Ga-In Lee Kyung-Ah Park Sei Yeul Oh Doo-Sik Kong Sang Duk Hong
author_facet	Ga-In Lee Kyung-Ah Park Sei Yeul Oh Doo-Sik Kong Sang Duk Hong
author_sort	Ga-In Lee
title	Inner and outer retinal layer thickness alterations in pediatric and juvenile craniopharyngioma
title_short	Inner and outer retinal layer thickness alterations in pediatric and juvenile craniopharyngioma
title_full	Inner and outer retinal layer thickness alterations in pediatric and juvenile craniopharyngioma
title_fullStr	Inner and outer retinal layer thickness alterations in pediatric and juvenile craniopharyngioma
title_full_unstemmed	Inner and outer retinal layer thickness alterations in pediatric and juvenile craniopharyngioma
title_sort	inner and outer retinal layer thickness alterations in pediatric and juvenile craniopharyngioma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1a765657aa264380a8d94d5b2ed1ad9a
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Inner and outer retinal layer thickness alterations in pediatric and juvenile craniopharyngioma

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