The circadian phase of antenatal glucocorticoid treatment affects the risk of behavioral disorders

Antenatal glucocorticoid therapy is indicated for mothers at risk of preterm delivery. Here, the authors show that the circadian phase of antenatal glucocorticoid treatment affects the risk of behavioral disorders later in life in mice and in a retrospective observational study in human infants.

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Autores principales: Mariana Astiz, Isabel Heyde, Mats Ingmar Fortmann, Verena Bossung, Claudia Roll, Anja Stein, Berthold Grüttner, Wolfgang Göpel, Christoph Härtel, Jonas Obleser, Henrik Oster
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Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/1a77159f7cad4c18bbc372837a3c2bf1
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spelling oai:doaj.org-article:1a77159f7cad4c18bbc372837a3c2bf12021-12-02T15:33:05ZThe circadian phase of antenatal glucocorticoid treatment affects the risk of behavioral disorders10.1038/s41467-020-17429-52041-1723https://doaj.org/article/1a77159f7cad4c18bbc372837a3c2bf12020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17429-5https://doaj.org/toc/2041-1723Antenatal glucocorticoid therapy is indicated for mothers at risk of preterm delivery. Here, the authors show that the circadian phase of antenatal glucocorticoid treatment affects the risk of behavioral disorders later in life in mice and in a retrospective observational study in human infants.Mariana AstizIsabel HeydeMats Ingmar FortmannVerena BossungClaudia RollAnja SteinBerthold GrüttnerWolfgang GöpelChristoph HärtelJonas ObleserHenrik OsterNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Mariana Astiz
Isabel Heyde
Mats Ingmar Fortmann
Verena Bossung
Claudia Roll
Anja Stein
Berthold Grüttner
Wolfgang Göpel
Christoph Härtel
Jonas Obleser
Henrik Oster
The circadian phase of antenatal glucocorticoid treatment affects the risk of behavioral disorders
description Antenatal glucocorticoid therapy is indicated for mothers at risk of preterm delivery. Here, the authors show that the circadian phase of antenatal glucocorticoid treatment affects the risk of behavioral disorders later in life in mice and in a retrospective observational study in human infants.
format article
author Mariana Astiz
Isabel Heyde
Mats Ingmar Fortmann
Verena Bossung
Claudia Roll
Anja Stein
Berthold Grüttner
Wolfgang Göpel
Christoph Härtel
Jonas Obleser
Henrik Oster
author_facet Mariana Astiz
Isabel Heyde
Mats Ingmar Fortmann
Verena Bossung
Claudia Roll
Anja Stein
Berthold Grüttner
Wolfgang Göpel
Christoph Härtel
Jonas Obleser
Henrik Oster
author_sort Mariana Astiz
title The circadian phase of antenatal glucocorticoid treatment affects the risk of behavioral disorders
title_short The circadian phase of antenatal glucocorticoid treatment affects the risk of behavioral disorders
title_full The circadian phase of antenatal glucocorticoid treatment affects the risk of behavioral disorders
title_fullStr The circadian phase of antenatal glucocorticoid treatment affects the risk of behavioral disorders
title_full_unstemmed The circadian phase of antenatal glucocorticoid treatment affects the risk of behavioral disorders
title_sort circadian phase of antenatal glucocorticoid treatment affects the risk of behavioral disorders
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/1a77159f7cad4c18bbc372837a3c2bf1
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