Synthesis of a thermoresponsive crosslinked MEO2MA polymer coating on microclusters of iron oxide nanoparticles
Abstract Encapsulation of magnetic nanoparticles (MNPs) of iron (II, III) oxide (Fe3O4) with a thermopolymeric shell of a crosslinked poly(2-(2-methoxyethoxy)ethyl methacrylate) P(MEO2MA) is successfully developed. Magnetic aggregates of large size, around 150–200 nm are obtained during the function...
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2021
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oai:doaj.org-article:1a77b3927b444705b508e894f8f6d5fb2021-12-02T10:54:30ZSynthesis of a thermoresponsive crosslinked MEO2MA polymer coating on microclusters of iron oxide nanoparticles10.1038/s41598-021-83608-z2045-2322https://doaj.org/article/1a77b3927b444705b508e894f8f6d5fb2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83608-zhttps://doaj.org/toc/2045-2322Abstract Encapsulation of magnetic nanoparticles (MNPs) of iron (II, III) oxide (Fe3O4) with a thermopolymeric shell of a crosslinked poly(2-(2-methoxyethoxy)ethyl methacrylate) P(MEO2MA) is successfully developed. Magnetic aggregates of large size, around 150–200 nm are obtained during the functionalization of the iron oxide NPs with vinyl groups by using 3-butenoic acid in the presence of a water soluble azo-initiator and a surfactant, at 70 °C. These polymerizable groups provide a covalent attachment of the P(MEO2MA) shell on the surface of the MNPs while a crosslinked network is achieved by including tetraethylene glycol dimethacrylate in the precipitation polymerization synthesis. Temperature control is used to modulate the swelling-to-collapse transition volume until a maximum of around 21:1 ratio between the expanded: shrunk states (from 364 to 144 nm in diameter) between 9 and 49 °C. The hybrid Fe3O4@P(MEO2MA) microgel exhibits a lower critical solution temperature of 21.9 °C below the corresponding value for P(MEO2MA) (bulk, 26 °C). The MEO2MA coating performance in the hybrid microgel is characterized by dynamic light scattering and transmission electron microscopy. The content of preformed MNPs [up to 30.2 (wt%) vs. microgel] was established by thermogravimetric analysis while magnetic properties by vibrating sample magnetometry.Alejandro Lapresta-FernándezAlfonso Salinas-CastilloLuis Fermín Capitán-VallveyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021) |
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Medicine R Science Q Alejandro Lapresta-Fernández Alfonso Salinas-Castillo Luis Fermín Capitán-Vallvey Synthesis of a thermoresponsive crosslinked MEO2MA polymer coating on microclusters of iron oxide nanoparticles |
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Abstract Encapsulation of magnetic nanoparticles (MNPs) of iron (II, III) oxide (Fe3O4) with a thermopolymeric shell of a crosslinked poly(2-(2-methoxyethoxy)ethyl methacrylate) P(MEO2MA) is successfully developed. Magnetic aggregates of large size, around 150–200 nm are obtained during the functionalization of the iron oxide NPs with vinyl groups by using 3-butenoic acid in the presence of a water soluble azo-initiator and a surfactant, at 70 °C. These polymerizable groups provide a covalent attachment of the P(MEO2MA) shell on the surface of the MNPs while a crosslinked network is achieved by including tetraethylene glycol dimethacrylate in the precipitation polymerization synthesis. Temperature control is used to modulate the swelling-to-collapse transition volume until a maximum of around 21:1 ratio between the expanded: shrunk states (from 364 to 144 nm in diameter) between 9 and 49 °C. The hybrid Fe3O4@P(MEO2MA) microgel exhibits a lower critical solution temperature of 21.9 °C below the corresponding value for P(MEO2MA) (bulk, 26 °C). The MEO2MA coating performance in the hybrid microgel is characterized by dynamic light scattering and transmission electron microscopy. The content of preformed MNPs [up to 30.2 (wt%) vs. microgel] was established by thermogravimetric analysis while magnetic properties by vibrating sample magnetometry. |
format |
article |
author |
Alejandro Lapresta-Fernández Alfonso Salinas-Castillo Luis Fermín Capitán-Vallvey |
author_facet |
Alejandro Lapresta-Fernández Alfonso Salinas-Castillo Luis Fermín Capitán-Vallvey |
author_sort |
Alejandro Lapresta-Fernández |
title |
Synthesis of a thermoresponsive crosslinked MEO2MA polymer coating on microclusters of iron oxide nanoparticles |
title_short |
Synthesis of a thermoresponsive crosslinked MEO2MA polymer coating on microclusters of iron oxide nanoparticles |
title_full |
Synthesis of a thermoresponsive crosslinked MEO2MA polymer coating on microclusters of iron oxide nanoparticles |
title_fullStr |
Synthesis of a thermoresponsive crosslinked MEO2MA polymer coating on microclusters of iron oxide nanoparticles |
title_full_unstemmed |
Synthesis of a thermoresponsive crosslinked MEO2MA polymer coating on microclusters of iron oxide nanoparticles |
title_sort |
synthesis of a thermoresponsive crosslinked meo2ma polymer coating on microclusters of iron oxide nanoparticles |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/1a77b3927b444705b508e894f8f6d5fb |
work_keys_str_mv |
AT alejandrolaprestafernandez synthesisofathermoresponsivecrosslinkedmeo2mapolymercoatingonmicroclustersofironoxidenanoparticles AT alfonsosalinascastillo synthesisofathermoresponsivecrosslinkedmeo2mapolymercoatingonmicroclustersofironoxidenanoparticles AT luisfermincapitanvallvey synthesisofathermoresponsivecrosslinkedmeo2mapolymercoatingonmicroclustersofironoxidenanoparticles |
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1718396455138361344 |