Synthesis of a thermoresponsive crosslinked MEO2MA polymer coating on microclusters of iron oxide nanoparticles

Abstract Encapsulation of magnetic nanoparticles (MNPs) of iron (II, III) oxide (Fe3O4) with a thermopolymeric shell of a crosslinked poly(2-(2-methoxyethoxy)ethyl methacrylate) P(MEO2MA) is successfully developed. Magnetic aggregates of large size, around 150–200 nm are obtained during the function...

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Autores principales:	Alejandro Lapresta-Fernández, Alfonso Salinas-Castillo, Luis Fermín Capitán-Vallvey
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1a77b3927b444705b508e894f8f6d5fb
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spelling	oai:doaj.org-article:1a77b3927b444705b508e894f8f6d5fb2021-12-02T10:54:30ZSynthesis of a thermoresponsive crosslinked MEO2MA polymer coating on microclusters of iron oxide nanoparticles10.1038/s41598-021-83608-z2045-2322https://doaj.org/article/1a77b3927b444705b508e894f8f6d5fb2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83608-zhttps://doaj.org/toc/2045-2322Abstract Encapsulation of magnetic nanoparticles (MNPs) of iron (II, III) oxide (Fe3O4) with a thermopolymeric shell of a crosslinked poly(2-(2-methoxyethoxy)ethyl methacrylate) P(MEO2MA) is successfully developed. Magnetic aggregates of large size, around 150–200 nm are obtained during the functionalization of the iron oxide NPs with vinyl groups by using 3-butenoic acid in the presence of a water soluble azo-initiator and a surfactant, at 70 °C. These polymerizable groups provide a covalent attachment of the P(MEO2MA) shell on the surface of the MNPs while a crosslinked network is achieved by including tetraethylene glycol dimethacrylate in the precipitation polymerization synthesis. Temperature control is used to modulate the swelling-to-collapse transition volume until a maximum of around 21:1 ratio between the expanded: shrunk states (from 364 to 144 nm in diameter) between 9 and 49 °C. The hybrid Fe3O4@P(MEO2MA) microgel exhibits a lower critical solution temperature of 21.9 °C below the corresponding value for P(MEO2MA) (bulk, 26 °C). The MEO2MA coating performance in the hybrid microgel is characterized by dynamic light scattering and transmission electron microscopy. The content of preformed MNPs [up to 30.2 (wt%) vs. microgel] was established by thermogravimetric analysis while magnetic properties by vibrating sample magnetometry.Alejandro Lapresta-FernándezAlfonso Salinas-CastilloLuis Fermín Capitán-VallveyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alejandro Lapresta-Fernández Alfonso Salinas-Castillo Luis Fermín Capitán-Vallvey Synthesis of a thermoresponsive crosslinked MEO2MA polymer coating on microclusters of iron oxide nanoparticles
description	Abstract Encapsulation of magnetic nanoparticles (MNPs) of iron (II, III) oxide (Fe3O4) with a thermopolymeric shell of a crosslinked poly(2-(2-methoxyethoxy)ethyl methacrylate) P(MEO2MA) is successfully developed. Magnetic aggregates of large size, around 150–200 nm are obtained during the functionalization of the iron oxide NPs with vinyl groups by using 3-butenoic acid in the presence of a water soluble azo-initiator and a surfactant, at 70 °C. These polymerizable groups provide a covalent attachment of the P(MEO2MA) shell on the surface of the MNPs while a crosslinked network is achieved by including tetraethylene glycol dimethacrylate in the precipitation polymerization synthesis. Temperature control is used to modulate the swelling-to-collapse transition volume until a maximum of around 21:1 ratio between the expanded: shrunk states (from 364 to 144 nm in diameter) between 9 and 49 °C. The hybrid Fe3O4@P(MEO2MA) microgel exhibits a lower critical solution temperature of 21.9 °C below the corresponding value for P(MEO2MA) (bulk, 26 °C). The MEO2MA coating performance in the hybrid microgel is characterized by dynamic light scattering and transmission electron microscopy. The content of preformed MNPs [up to 30.2 (wt%) vs. microgel] was established by thermogravimetric analysis while magnetic properties by vibrating sample magnetometry.
format	article
author	Alejandro Lapresta-Fernández Alfonso Salinas-Castillo Luis Fermín Capitán-Vallvey
author_facet	Alejandro Lapresta-Fernández Alfonso Salinas-Castillo Luis Fermín Capitán-Vallvey
author_sort	Alejandro Lapresta-Fernández
title	Synthesis of a thermoresponsive crosslinked MEO2MA polymer coating on microclusters of iron oxide nanoparticles
title_short	Synthesis of a thermoresponsive crosslinked MEO2MA polymer coating on microclusters of iron oxide nanoparticles
title_full	Synthesis of a thermoresponsive crosslinked MEO2MA polymer coating on microclusters of iron oxide nanoparticles
title_fullStr	Synthesis of a thermoresponsive crosslinked MEO2MA polymer coating on microclusters of iron oxide nanoparticles
title_full_unstemmed	Synthesis of a thermoresponsive crosslinked MEO2MA polymer coating on microclusters of iron oxide nanoparticles
title_sort	synthesis of a thermoresponsive crosslinked meo2ma polymer coating on microclusters of iron oxide nanoparticles
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1a77b3927b444705b508e894f8f6d5fb
work_keys_str_mv	AT alejandrolaprestafernandez synthesisofathermoresponsivecrosslinkedmeo2mapolymercoatingonmicroclustersofironoxidenanoparticles AT alfonsosalinascastillo synthesisofathermoresponsivecrosslinkedmeo2mapolymercoatingonmicroclustersofironoxidenanoparticles AT luisfermincapitanvallvey synthesisofathermoresponsivecrosslinkedmeo2mapolymercoatingonmicroclustersofironoxidenanoparticles
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Synthesis of a thermoresponsive crosslinked MEO2MA polymer coating on microclusters of iron oxide nanoparticles

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