Role of neuro-sonography of peripheral nerves as a diagnostic and a differentiation tool of amyotrophic lateral sclerosis

Abstract Background Motor neuron disease is a heterogeneous group of progressive neurodegenerative disorders, most common of which is amyotrophic lateral sclerosis (ALS). There are many clinical and radiological criteria to diagnose amyotrophic lateral sclerosis and to differentiate it from other mo...

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Autores principales:	Rana Zakaria Ahmed Mohamed, Haitham Hamdy Salem, Hossam Moussa El-Sayed Sakr, Hossam-Eldin Mahmoud Afifi, Ahmed Mohammed Elsadek, Nagia Aly Fahmy
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	ALS Neuro-sonography Motor neuron disease Neuro-imaging Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/1a78d51ae37e461b8f9ce61e570cc7a8
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spelling	oai:doaj.org-article:1a78d51ae37e461b8f9ce61e570cc7a82021-11-08T10:44:30ZRole of neuro-sonography of peripheral nerves as a diagnostic and a differentiation tool of amyotrophic lateral sclerosis10.1186/s41983-021-00389-y1687-8329https://doaj.org/article/1a78d51ae37e461b8f9ce61e570cc7a82021-11-01T00:00:00Zhttps://doi.org/10.1186/s41983-021-00389-yhttps://doaj.org/toc/1687-8329Abstract Background Motor neuron disease is a heterogeneous group of progressive neurodegenerative disorders, most common of which is amyotrophic lateral sclerosis (ALS). There are many clinical and radiological criteria to diagnose amyotrophic lateral sclerosis and to differentiate it from other motor neuron disease and neurodegenerative disorders. Neuro-sonography is one of the easily applied tools to diagnose and differentiate ALS. ALS diagnosis is delayed up to 3 years according to some authors due to the wide differential diagnosis, with cervical degeneration being a common misdiagnosis. The objective of this study was to evaluate the role of neuro-sonography in diagnosis and differentiation of amyotrophic lateral sclerosis from other causes of progressive mixed upper and lower motor neuron lesion. Results A total neuro-sonography score at a cut-off point (≤ 127) predicted patients with ALS, with good (85%) accuracy, sensitivity = 73% and specificity = 83% (p < 0.01) and Lt median arm score at a cut-off point (≤ 6) predicted patients with ALS, with good (88%) accuracy, sensitivity = 86% and specificity = 86% (p < 0.01) and the median nerve at the arm level was the most sensitive and specific nerve to predict patients with ALS. Conclusion Neuro-sonography of peripheral nerves is a recent, noninvasive, accessible technique that can be used in early diagnosis of ALS.Rana Zakaria Ahmed MohamedHaitham Hamdy SalemHossam Moussa El-Sayed SakrHossam-Eldin Mahmoud AfifiAhmed Mohammed ElsadekNagia Aly FahmySpringerOpenarticleALSNeuro-sonographyMotor neuron diseaseNeuro-imagingNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery, Vol 57, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ALS Neuro-sonography Motor neuron disease Neuro-imaging Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	ALS Neuro-sonography Motor neuron disease Neuro-imaging Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Rana Zakaria Ahmed Mohamed Haitham Hamdy Salem Hossam Moussa El-Sayed Sakr Hossam-Eldin Mahmoud Afifi Ahmed Mohammed Elsadek Nagia Aly Fahmy Role of neuro-sonography of peripheral nerves as a diagnostic and a differentiation tool of amyotrophic lateral sclerosis
description	Abstract Background Motor neuron disease is a heterogeneous group of progressive neurodegenerative disorders, most common of which is amyotrophic lateral sclerosis (ALS). There are many clinical and radiological criteria to diagnose amyotrophic lateral sclerosis and to differentiate it from other motor neuron disease and neurodegenerative disorders. Neuro-sonography is one of the easily applied tools to diagnose and differentiate ALS. ALS diagnosis is delayed up to 3 years according to some authors due to the wide differential diagnosis, with cervical degeneration being a common misdiagnosis. The objective of this study was to evaluate the role of neuro-sonography in diagnosis and differentiation of amyotrophic lateral sclerosis from other causes of progressive mixed upper and lower motor neuron lesion. Results A total neuro-sonography score at a cut-off point (≤ 127) predicted patients with ALS, with good (85%) accuracy, sensitivity = 73% and specificity = 83% (p < 0.01) and Lt median arm score at a cut-off point (≤ 6) predicted patients with ALS, with good (88%) accuracy, sensitivity = 86% and specificity = 86% (p < 0.01) and the median nerve at the arm level was the most sensitive and specific nerve to predict patients with ALS. Conclusion Neuro-sonography of peripheral nerves is a recent, noninvasive, accessible technique that can be used in early diagnosis of ALS.
format	article
author	Rana Zakaria Ahmed Mohamed Haitham Hamdy Salem Hossam Moussa El-Sayed Sakr Hossam-Eldin Mahmoud Afifi Ahmed Mohammed Elsadek Nagia Aly Fahmy
author_facet	Rana Zakaria Ahmed Mohamed Haitham Hamdy Salem Hossam Moussa El-Sayed Sakr Hossam-Eldin Mahmoud Afifi Ahmed Mohammed Elsadek Nagia Aly Fahmy
author_sort	Rana Zakaria Ahmed Mohamed
title	Role of neuro-sonography of peripheral nerves as a diagnostic and a differentiation tool of amyotrophic lateral sclerosis
title_short	Role of neuro-sonography of peripheral nerves as a diagnostic and a differentiation tool of amyotrophic lateral sclerosis
title_full	Role of neuro-sonography of peripheral nerves as a diagnostic and a differentiation tool of amyotrophic lateral sclerosis
title_fullStr	Role of neuro-sonography of peripheral nerves as a diagnostic and a differentiation tool of amyotrophic lateral sclerosis
title_full_unstemmed	Role of neuro-sonography of peripheral nerves as a diagnostic and a differentiation tool of amyotrophic lateral sclerosis
title_sort	role of neuro-sonography of peripheral nerves as a diagnostic and a differentiation tool of amyotrophic lateral sclerosis
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/1a78d51ae37e461b8f9ce61e570cc7a8
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Role of neuro-sonography of peripheral nerves as a diagnostic and a differentiation tool of amyotrophic lateral sclerosis

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