The influence of gestational hypertension on cord blood adiponectin levels: a case-controlled study
Introduction: Gestational hypertension is one of the most common complications of pregnancy and childbirth worldwide and may be associated with metabolic disorders. Adiponectin is an adipocyte-specific plasma protein with insulin-sensitizing, vascular-protective, anti-inflammatory properties, and it...
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SAGE Publishing
2021
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oai:doaj.org-article:1a7c544d36f0435e8f686e55183ad6412021-12-01T00:05:27ZThe influence of gestational hypertension on cord blood adiponectin levels: a case-controlled study2042-019610.1177/20420188211058582https://doaj.org/article/1a7c544d36f0435e8f686e55183ad6412021-11-01T00:00:00Zhttps://doi.org/10.1177/20420188211058582https://doaj.org/toc/2042-0196Introduction: Gestational hypertension is one of the most common complications of pregnancy and childbirth worldwide and may be associated with metabolic disorders. Adiponectin is an adipocyte-specific plasma protein with insulin-sensitizing, vascular-protective, anti-inflammatory properties, and its role in metabolic disorders in prenatal and postnatal development in neonates remains unclear. The primary purpose of this study was to determine whether gestational hypertension is a condition lowering cord blood adiponectin level. Next, we have evaluated whether cord blood adiponectin level correlates with selected anthropometric parameters in neonates. Material and methods: The case–control study included 89 newborns divided into two groups: 30 neonates in the study group whose mothers were diagnosed with gestational hypertension and 59 healthy neonates born from normotensive pregnancies. Adiponectin determinations were performed in both groups, and neonatal anthropometric measurements and perinatal data were collected. Results: There was no statistically significant difference ( p = 0.27) between adiponectin concentration in cord blood of newborns from the study group [median (Q1–Q3) 9.86 μg/ml (8.16–13.26 μg/ml)] compared with the control group [median (Q1–Q3) 10.65 μg/ml (8.69–14.29 μg/ml)]. No statistically significant correlations were observed between adiponectin level and gestational age, body weight, body length, and chest circumference. A significant correlation was observed between adiponectin level and head circumference among newborns in the control group and among the entire population of newborns included in the study. Conclusion: No significant influence of gestational hypertension on cord blood adiponectin levels or their correlation with neonatal anthropometric measurements was observed.Justyna Czubilińska-ŁadaAleksandra GliwińskaElżbieta ŚwiȩtochowskaLucyna Nowak-BorzȩckaBeata SadownikJakub BehrendtMaria SzczepańskaSAGE PublishingarticleDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENTherapeutic Advances in Endocrinology and Metabolism, Vol 12 (2021) |
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DOAJ |
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EN |
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Diseases of the endocrine glands. Clinical endocrinology RC648-665 |
| spellingShingle |
Diseases of the endocrine glands. Clinical endocrinology RC648-665 Justyna Czubilińska-Łada Aleksandra Gliwińska Elżbieta Świȩtochowska Lucyna Nowak-Borzȩcka Beata Sadownik Jakub Behrendt Maria Szczepańska The influence of gestational hypertension on cord blood adiponectin levels: a case-controlled study |
| description |
Introduction: Gestational hypertension is one of the most common complications of pregnancy and childbirth worldwide and may be associated with metabolic disorders. Adiponectin is an adipocyte-specific plasma protein with insulin-sensitizing, vascular-protective, anti-inflammatory properties, and its role in metabolic disorders in prenatal and postnatal development in neonates remains unclear. The primary purpose of this study was to determine whether gestational hypertension is a condition lowering cord blood adiponectin level. Next, we have evaluated whether cord blood adiponectin level correlates with selected anthropometric parameters in neonates. Material and methods: The case–control study included 89 newborns divided into two groups: 30 neonates in the study group whose mothers were diagnosed with gestational hypertension and 59 healthy neonates born from normotensive pregnancies. Adiponectin determinations were performed in both groups, and neonatal anthropometric measurements and perinatal data were collected. Results: There was no statistically significant difference ( p = 0.27) between adiponectin concentration in cord blood of newborns from the study group [median (Q1–Q3) 9.86 μg/ml (8.16–13.26 μg/ml)] compared with the control group [median (Q1–Q3) 10.65 μg/ml (8.69–14.29 μg/ml)]. No statistically significant correlations were observed between adiponectin level and gestational age, body weight, body length, and chest circumference. A significant correlation was observed between adiponectin level and head circumference among newborns in the control group and among the entire population of newborns included in the study. Conclusion: No significant influence of gestational hypertension on cord blood adiponectin levels or their correlation with neonatal anthropometric measurements was observed. |
| format |
article |
| author |
Justyna Czubilińska-Łada Aleksandra Gliwińska Elżbieta Świȩtochowska Lucyna Nowak-Borzȩcka Beata Sadownik Jakub Behrendt Maria Szczepańska |
| author_facet |
Justyna Czubilińska-Łada Aleksandra Gliwińska Elżbieta Świȩtochowska Lucyna Nowak-Borzȩcka Beata Sadownik Jakub Behrendt Maria Szczepańska |
| author_sort |
Justyna Czubilińska-Łada |
| title |
The influence of gestational hypertension on cord blood adiponectin levels: a case-controlled study |
| title_short |
The influence of gestational hypertension on cord blood adiponectin levels: a case-controlled study |
| title_full |
The influence of gestational hypertension on cord blood adiponectin levels: a case-controlled study |
| title_fullStr |
The influence of gestational hypertension on cord blood adiponectin levels: a case-controlled study |
| title_full_unstemmed |
The influence of gestational hypertension on cord blood adiponectin levels: a case-controlled study |
| title_sort |
influence of gestational hypertension on cord blood adiponectin levels: a case-controlled study |
| publisher |
SAGE Publishing |
| publishDate |
2021 |
| url |
https://doaj.org/article/1a7c544d36f0435e8f686e55183ad641 |
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