Azilsartan increases levels of IL-10, down-regulates MMP-2, MMP-9, RANKL/RANK, Cathepsin K and up-regulates OPG in an experimental periodontitis model.

Azilsartan increases levels of IL-10, down-regulates MMP-2, MMP-9, RANKL/RANK, Cathepsin K and up-regulates OPG in an experimental periodontitis model.

<h4>Aims</h4>The aim of this study was to evaluate the effects of azilsartan (AZT) on bone loss, inflammation, and the expression of matrix metallo proteinases (MMPs), receptor activator of nuclear factor κB ligand (RANKL), receptor activator of nuclear factor κB (RANK), osteoprotegerin...

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Main Authors: Aurigena Antunes de Araújo, Hugo Varela, Gerly Anne de Castro Brito, Caroline Addison Carvalho Xavier de Medeiros, Lorena de Souza Araújo, José Heriberto Oliveira do Nascimento, Raimundo Fernandes de Araújo Júnior
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2014
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/1a7d800fce3a4ba397ec52b701f69b19
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https://doaj.org/article/1a7d800fce3a4ba397ec52b701f69b19

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