A Rapid Dual-Responsive Releasing Nano-Carrier by Decomposing the Copolymer and Reversing the Core Dissolution
The accumulation of nanotechnology-based drugs has been realized in various ways. However, the concentration of drugs encapsulated by nanomaterials is not equal to the concentration of effective drugs; often, the drugs become effective only when they are released from the nanomaterials as free drugs...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:1a813758f0fb434cac485f6c82624c1e2021-11-04T04:53:41ZA Rapid Dual-Responsive Releasing Nano-Carrier by Decomposing the Copolymer and Reversing the Core Dissolution2296-418510.3389/fbioe.2021.784838https://doaj.org/article/1a813758f0fb434cac485f6c82624c1e2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fbioe.2021.784838/fullhttps://doaj.org/toc/2296-4185The accumulation of nanotechnology-based drugs has been realized in various ways. However, the concentration of drugs encapsulated by nanomaterials is not equal to the concentration of effective drugs; often, the drugs become effective only when they are released from the nanomaterials as free drugs. This means only when the drugs are rapidly released after the accumulated drug-encapsulating nanomaterials can they truly achieve the purpose of increasing the concentration of drugs in the tumor. Therefore, we herein report a dual-response nano-carrier of glutathione and acid to achieve the rapid release of encapsulated drug and increase the effective drug concentration in the tumor. The nano-carrier was constructed using a dual-responsive amphiphilic copolymer, composed of polyethylene glycol and hydrophobic acetylated dextran and connected by a disulfide bond. In the tumor microenvironment, disulfide bonds could be biodegraded by glutathione that is overexpressed in the tumor, exposing the core of nano-carrier composed of acetylated dextran. Then the acidic environment would induce the deacetylation of acetylated dextran into water-soluble dextran. In this way, the nano-carrier will degrade quickly, realizing the purpose of rapid drug release. The results showed that the drug release rate of dual-responsive nano-carrier was much higher than that of glutathione or acid-responsive nano-carrier alone. Furthermore, both in vitro and in vivo experiments confirmed that dual-responsive nano-carrier possessed more efficient anti-tumor effects. Therefore, we believe that dual-responsive nano-carriers have better clinical application prospects.Sen LiuCan ShenCheng QianJianquan WangZhihao WangXuecong TangQiuyang ZhangChangjiang PanWei YeFrontiers Media S.A.articledual-responsivenano-carrierdissolution reversingrapid drug releasetumor chemotherapyBiotechnologyTP248.13-248.65ENFrontiers in Bioengineering and Biotechnology, Vol 9 (2021) |
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DOAJ |
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DOAJ |
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| topic |
dual-responsive nano-carrier dissolution reversing rapid drug release tumor chemotherapy Biotechnology TP248.13-248.65 |
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dual-responsive nano-carrier dissolution reversing rapid drug release tumor chemotherapy Biotechnology TP248.13-248.65 Sen Liu Can Shen Cheng Qian Jianquan Wang Zhihao Wang Xuecong Tang Qiuyang Zhang Changjiang Pan Wei Ye A Rapid Dual-Responsive Releasing Nano-Carrier by Decomposing the Copolymer and Reversing the Core Dissolution |
| description |
The accumulation of nanotechnology-based drugs has been realized in various ways. However, the concentration of drugs encapsulated by nanomaterials is not equal to the concentration of effective drugs; often, the drugs become effective only when they are released from the nanomaterials as free drugs. This means only when the drugs are rapidly released after the accumulated drug-encapsulating nanomaterials can they truly achieve the purpose of increasing the concentration of drugs in the tumor. Therefore, we herein report a dual-response nano-carrier of glutathione and acid to achieve the rapid release of encapsulated drug and increase the effective drug concentration in the tumor. The nano-carrier was constructed using a dual-responsive amphiphilic copolymer, composed of polyethylene glycol and hydrophobic acetylated dextran and connected by a disulfide bond. In the tumor microenvironment, disulfide bonds could be biodegraded by glutathione that is overexpressed in the tumor, exposing the core of nano-carrier composed of acetylated dextran. Then the acidic environment would induce the deacetylation of acetylated dextran into water-soluble dextran. In this way, the nano-carrier will degrade quickly, realizing the purpose of rapid drug release. The results showed that the drug release rate of dual-responsive nano-carrier was much higher than that of glutathione or acid-responsive nano-carrier alone. Furthermore, both in vitro and in vivo experiments confirmed that dual-responsive nano-carrier possessed more efficient anti-tumor effects. Therefore, we believe that dual-responsive nano-carriers have better clinical application prospects. |
| format |
article |
| author |
Sen Liu Can Shen Cheng Qian Jianquan Wang Zhihao Wang Xuecong Tang Qiuyang Zhang Changjiang Pan Wei Ye |
| author_facet |
Sen Liu Can Shen Cheng Qian Jianquan Wang Zhihao Wang Xuecong Tang Qiuyang Zhang Changjiang Pan Wei Ye |
| author_sort |
Sen Liu |
| title |
A Rapid Dual-Responsive Releasing Nano-Carrier by Decomposing the Copolymer and Reversing the Core Dissolution |
| title_short |
A Rapid Dual-Responsive Releasing Nano-Carrier by Decomposing the Copolymer and Reversing the Core Dissolution |
| title_full |
A Rapid Dual-Responsive Releasing Nano-Carrier by Decomposing the Copolymer and Reversing the Core Dissolution |
| title_fullStr |
A Rapid Dual-Responsive Releasing Nano-Carrier by Decomposing the Copolymer and Reversing the Core Dissolution |
| title_full_unstemmed |
A Rapid Dual-Responsive Releasing Nano-Carrier by Decomposing the Copolymer and Reversing the Core Dissolution |
| title_sort |
rapid dual-responsive releasing nano-carrier by decomposing the copolymer and reversing the core dissolution |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/1a813758f0fb434cac485f6c82624c1e |
| work_keys_str_mv |
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