Temporal clustering of Kawasaki disease cases around the world

Abstract In a single-site study (San Diego, CA, USA), we previously showed that Kawasaki Disease (KD) cases cluster temporally in bursts of approximately 7 days. These clusters occurred more often than would be expected at random even after accounting for long-term trends and seasonality. This findi...

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Autores principales:	Jennifer A. Burney, Laurel L. DeHaan, Chisato Shimizu, Emelia V. Bainto, Jane W. Newburger, Roberta L. DeBiasi, Samuel R. Dominguez, Michael A. Portman, Marian Melish, Andras Bratincsak, Marianna Fabi, Elena Corinaldesi, Jeong Jin Yu, Paul Gee, Naomi Kitano, Adriana H. Tremoulet, Daniel R. Cayan, Jane C. Burns, the Kawasaki Disease Climate Study Group
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1a847cd00acf42789d7bc783a4b129a5
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spelling	oai:doaj.org-article:1a847cd00acf42789d7bc783a4b129a52021-11-21T12:23:40ZTemporal clustering of Kawasaki disease cases around the world10.1038/s41598-021-01961-52045-2322https://doaj.org/article/1a847cd00acf42789d7bc783a4b129a52021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01961-5https://doaj.org/toc/2045-2322Abstract In a single-site study (San Diego, CA, USA), we previously showed that Kawasaki Disease (KD) cases cluster temporally in bursts of approximately 7 days. These clusters occurred more often than would be expected at random even after accounting for long-term trends and seasonality. This finding raised the question of whether other locations around the world experience similar temporal clusters of KD that might offer clues to disease etiology. Here we combine data from San Diego and nine additional sites around the world with hospitals that care for large numbers of KD patients, as well as two multi-hospital catchment regions. We found that across these sites, KD cases clustered at short time scales and there were anomalously long quiet periods with no cases. Both of these phenomena occurred more often than would be expected given local trends and seasonality. Additionally, we found unusually frequent temporal overlaps of KD clusters and quiet periods between pairs of sites. These findings suggest that regional and planetary range environmental influences create periods of higher or lower exposure to KD triggers that may offer clues to the etiology of KD.Jennifer A. BurneyLaurel L. DeHaanChisato ShimizuEmelia V. BaintoJane W. NewburgerRoberta L. DeBiasiSamuel R. DominguezMichael A. PortmanMarian MelishAndras BratincsakMarianna FabiElena CorinaldesiJeong Jin YuPaul GeeNaomi KitanoAdriana H. TremouletDaniel R. CayanJane C. Burnsthe Kawasaki Disease Climate Study GroupNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jennifer A. Burney Laurel L. DeHaan Chisato Shimizu Emelia V. Bainto Jane W. Newburger Roberta L. DeBiasi Samuel R. Dominguez Michael A. Portman Marian Melish Andras Bratincsak Marianna Fabi Elena Corinaldesi Jeong Jin Yu Paul Gee Naomi Kitano Adriana H. Tremoulet Daniel R. Cayan Jane C. Burns the Kawasaki Disease Climate Study Group Temporal clustering of Kawasaki disease cases around the world
description	Abstract In a single-site study (San Diego, CA, USA), we previously showed that Kawasaki Disease (KD) cases cluster temporally in bursts of approximately 7 days. These clusters occurred more often than would be expected at random even after accounting for long-term trends and seasonality. This finding raised the question of whether other locations around the world experience similar temporal clusters of KD that might offer clues to disease etiology. Here we combine data from San Diego and nine additional sites around the world with hospitals that care for large numbers of KD patients, as well as two multi-hospital catchment regions. We found that across these sites, KD cases clustered at short time scales and there were anomalously long quiet periods with no cases. Both of these phenomena occurred more often than would be expected given local trends and seasonality. Additionally, we found unusually frequent temporal overlaps of KD clusters and quiet periods between pairs of sites. These findings suggest that regional and planetary range environmental influences create periods of higher or lower exposure to KD triggers that may offer clues to the etiology of KD.
format	article
author	Jennifer A. Burney Laurel L. DeHaan Chisato Shimizu Emelia V. Bainto Jane W. Newburger Roberta L. DeBiasi Samuel R. Dominguez Michael A. Portman Marian Melish Andras Bratincsak Marianna Fabi Elena Corinaldesi Jeong Jin Yu Paul Gee Naomi Kitano Adriana H. Tremoulet Daniel R. Cayan Jane C. Burns the Kawasaki Disease Climate Study Group
author_facet	Jennifer A. Burney Laurel L. DeHaan Chisato Shimizu Emelia V. Bainto Jane W. Newburger Roberta L. DeBiasi Samuel R. Dominguez Michael A. Portman Marian Melish Andras Bratincsak Marianna Fabi Elena Corinaldesi Jeong Jin Yu Paul Gee Naomi Kitano Adriana H. Tremoulet Daniel R. Cayan Jane C. Burns the Kawasaki Disease Climate Study Group
author_sort	Jennifer A. Burney
title	Temporal clustering of Kawasaki disease cases around the world
title_short	Temporal clustering of Kawasaki disease cases around the world
title_full	Temporal clustering of Kawasaki disease cases around the world
title_fullStr	Temporal clustering of Kawasaki disease cases around the world
title_full_unstemmed	Temporal clustering of Kawasaki disease cases around the world
title_sort	temporal clustering of kawasaki disease cases around the world
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1a847cd00acf42789d7bc783a4b129a5
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Temporal clustering of Kawasaki disease cases around the world

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