Increased Serum Levels of S100A4 and S100A15 in Individuals Suffering from Hidradenitis Suppurativa

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease. Recently, some S100 proteins have been suggested to play an important role in the pathogenesis of chronic immune-mediated inflammatory diseases and they may constitute valuable biomarkers for these diseases’ diagnosis and monitori...

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Autores principales:	Aleksandra Batycka-Baran, Łukasz Matusiak, Danuta Nowicka-Suszko, Jacek C. Szepietowski, Wojciech Baran
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	S100A4 S100A15 hidradenitis suppurativa Medicine R
Acceso en línea:	https://doaj.org/article/1a90a61ac43344bca62c9a7d972a855f
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spelling	oai:doaj.org-article:1a90a61ac43344bca62c9a7d972a855f2021-11-25T18:01:40ZIncreased Serum Levels of S100A4 and S100A15 in Individuals Suffering from Hidradenitis Suppurativa10.3390/jcm102253202077-0383https://doaj.org/article/1a90a61ac43344bca62c9a7d972a855f2021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5320https://doaj.org/toc/2077-0383Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease. Recently, some S100 proteins have been suggested to play an important role in the pathogenesis of chronic immune-mediated inflammatory diseases and they may constitute valuable biomarkers for these diseases’ diagnosis and monitoring. The objective of the current study was to investigate, for the first time, serum levels of S100A4 and S100A15 in individuals suffering from HS. Furthermore, we assessed the associations between S100A4 and S100A15 serum levels and the severity of disease, CRP serum concentration and some demographic and clinical data. Serum levels of S100A4 and S100A15 were evaluated with the commercially available ELISA kit according to the manufacturer’s instructions. The serum level of S100A4 in individuals with HS was significantly elevated as compared to controls, with the highest level found in the individuals in Hurley stage II. The S100A15 serum level was positively correlated with the CRP concentration and was associated with the severity of the disease. The serum level of S100A15 in the individuals in Hurley stage III was significantly elevated compared to that of the controls and the individuals with HS in Hurley stages I and II. S100A4 and S100A15 may be considered as new serum biomarkers for the monitoring of HS progression, and they may play a role in the pathogenesis of HS by promoting inflammatory process and fibrosis.Aleksandra Batycka-BaranŁukasz MatusiakDanuta Nowicka-SuszkoJacek C. SzepietowskiWojciech BaranMDPI AGarticleS100A4S100A15hidradenitis suppurativaMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5320, p 5320 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	S100A4 S100A15 hidradenitis suppurativa Medicine R
spellingShingle	S100A4 S100A15 hidradenitis suppurativa Medicine R Aleksandra Batycka-Baran Łukasz Matusiak Danuta Nowicka-Suszko Jacek C. Szepietowski Wojciech Baran Increased Serum Levels of S100A4 and S100A15 in Individuals Suffering from Hidradenitis Suppurativa
description	Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease. Recently, some S100 proteins have been suggested to play an important role in the pathogenesis of chronic immune-mediated inflammatory diseases and they may constitute valuable biomarkers for these diseases’ diagnosis and monitoring. The objective of the current study was to investigate, for the first time, serum levels of S100A4 and S100A15 in individuals suffering from HS. Furthermore, we assessed the associations between S100A4 and S100A15 serum levels and the severity of disease, CRP serum concentration and some demographic and clinical data. Serum levels of S100A4 and S100A15 were evaluated with the commercially available ELISA kit according to the manufacturer’s instructions. The serum level of S100A4 in individuals with HS was significantly elevated as compared to controls, with the highest level found in the individuals in Hurley stage II. The S100A15 serum level was positively correlated with the CRP concentration and was associated with the severity of the disease. The serum level of S100A15 in the individuals in Hurley stage III was significantly elevated compared to that of the controls and the individuals with HS in Hurley stages I and II. S100A4 and S100A15 may be considered as new serum biomarkers for the monitoring of HS progression, and they may play a role in the pathogenesis of HS by promoting inflammatory process and fibrosis.
format	article
author	Aleksandra Batycka-Baran Łukasz Matusiak Danuta Nowicka-Suszko Jacek C. Szepietowski Wojciech Baran
author_facet	Aleksandra Batycka-Baran Łukasz Matusiak Danuta Nowicka-Suszko Jacek C. Szepietowski Wojciech Baran
author_sort	Aleksandra Batycka-Baran
title	Increased Serum Levels of S100A4 and S100A15 in Individuals Suffering from Hidradenitis Suppurativa
title_short	Increased Serum Levels of S100A4 and S100A15 in Individuals Suffering from Hidradenitis Suppurativa
title_full	Increased Serum Levels of S100A4 and S100A15 in Individuals Suffering from Hidradenitis Suppurativa
title_fullStr	Increased Serum Levels of S100A4 and S100A15 in Individuals Suffering from Hidradenitis Suppurativa
title_full_unstemmed	Increased Serum Levels of S100A4 and S100A15 in Individuals Suffering from Hidradenitis Suppurativa
title_sort	increased serum levels of s100a4 and s100a15 in individuals suffering from hidradenitis suppurativa
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1a90a61ac43344bca62c9a7d972a855f
work_keys_str_mv	AT aleksandrabatyckabaran increasedserumlevelsofs100a4ands100a15inindividualssufferingfromhidradenitissuppurativa AT łukaszmatusiak increasedserumlevelsofs100a4ands100a15inindividualssufferingfromhidradenitissuppurativa AT danutanowickasuszko increasedserumlevelsofs100a4ands100a15inindividualssufferingfromhidradenitissuppurativa AT jacekcszepietowski increasedserumlevelsofs100a4ands100a15inindividualssufferingfromhidradenitissuppurativa AT wojciechbaran increasedserumlevelsofs100a4ands100a15inindividualssufferingfromhidradenitissuppurativa
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Increased Serum Levels of S100A4 and S100A15 in Individuals Suffering from Hidradenitis Suppurativa

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