Effectiveness of antiviral metal and metal oxide thin-film coatings against human coronavirus 229E

Virucidal thin-film coatings have the potential to inactivate pathogens on surfaces, preventing or slowing their spread. Six potential nanoscale antiviral coatings, Cu, Cu2O, Ag, ZnO, zinc tin oxide (ZTO), and TiO2, are deposited on glass, and their ability to inactivate the HCoV-229E human coronavi...

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Autores principales:	Louis-Vincent Delumeau, Hatameh Asgarimoghaddam, Tamiru Alkie, Alexander James Bryan Jones, Samantha Lum, Kissan Mistry, Marc G. Aucoin, Stephanie DeWitte-Orr, Kevin P. Musselman
Formato:	article
Lenguaje:	EN
Publicado:	AIP Publishing LLC 2021
Materias:	Biotechnology TP248.13-248.65 Physics QC1-999
Acceso en línea:	https://doaj.org/article/1a933bebcd8741ee9fb87a311d7fcec7
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spelling	oai:doaj.org-article:1a933bebcd8741ee9fb87a311d7fcec72021-12-01T18:51:23ZEffectiveness of antiviral metal and metal oxide thin-film coatings against human coronavirus 229E2166-532X10.1063/5.0056138https://doaj.org/article/1a933bebcd8741ee9fb87a311d7fcec72021-11-01T00:00:00Zhttp://dx.doi.org/10.1063/5.0056138https://doaj.org/toc/2166-532XVirucidal thin-film coatings have the potential to inactivate pathogens on surfaces, preventing or slowing their spread. Six potential nanoscale antiviral coatings, Cu, Cu2O, Ag, ZnO, zinc tin oxide (ZTO), and TiO2, are deposited on glass, and their ability to inactivate the HCoV-229E human coronavirus is assessed using two methods. In one method, droplets containing HCoV-229E are deposited on thin-film coatings and then collected after various stages of desiccation. In the second method, the thin-film coatings are soaked in the virus supernatant for 24 h. The Cu and Cu2O coatings demonstrate clear virucidal behavior, and it is shown that controlled delamination and dissolution of the coating can enhance the virucidal effect. Cu is found to produce a faster and stronger virucidal effect than Cu2O in the droplet tests (3 log reduction in the viral titer after 1 h of exposure), which is attributed, in part, to the differences in film adhesion that result in delamination of the Cu film from the glass and accelerated dissolution in the droplet. Despite Ag, ZnO, and TiO2 being frequently cited antimicrobial materials, exposure to the Ag, ZnO, ZTO, and TiO2 coatings results in no discernible change to the infectivity of the coronavirus under the conditions tested. Thin-film Cu coatings are also applied to the polypropylene fabrics of N95 respirators, and droplet tests are performed. The Cu fabric coating reduces the infectivity of the virus; it results in a 1 order-of-magnitude reduction in the viral titer within 15 min with a 2 order-of-magnitude reduction after 1 h.Louis-Vincent DelumeauHatameh AsgarimoghaddamTamiru AlkieAlexander James Bryan JonesSamantha LumKissan MistryMarc G. AucoinStephanie DeWitte-OrrKevin P. MusselmanAIP Publishing LLCarticleBiotechnologyTP248.13-248.65PhysicsQC1-999ENAPL Materials, Vol 9, Iss 11, Pp 111114-111114-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biotechnology TP248.13-248.65 Physics QC1-999
spellingShingle	Biotechnology TP248.13-248.65 Physics QC1-999 Louis-Vincent Delumeau Hatameh Asgarimoghaddam Tamiru Alkie Alexander James Bryan Jones Samantha Lum Kissan Mistry Marc G. Aucoin Stephanie DeWitte-Orr Kevin P. Musselman Effectiveness of antiviral metal and metal oxide thin-film coatings against human coronavirus 229E
description	Virucidal thin-film coatings have the potential to inactivate pathogens on surfaces, preventing or slowing their spread. Six potential nanoscale antiviral coatings, Cu, Cu2O, Ag, ZnO, zinc tin oxide (ZTO), and TiO2, are deposited on glass, and their ability to inactivate the HCoV-229E human coronavirus is assessed using two methods. In one method, droplets containing HCoV-229E are deposited on thin-film coatings and then collected after various stages of desiccation. In the second method, the thin-film coatings are soaked in the virus supernatant for 24 h. The Cu and Cu2O coatings demonstrate clear virucidal behavior, and it is shown that controlled delamination and dissolution of the coating can enhance the virucidal effect. Cu is found to produce a faster and stronger virucidal effect than Cu2O in the droplet tests (3 log reduction in the viral titer after 1 h of exposure), which is attributed, in part, to the differences in film adhesion that result in delamination of the Cu film from the glass and accelerated dissolution in the droplet. Despite Ag, ZnO, and TiO2 being frequently cited antimicrobial materials, exposure to the Ag, ZnO, ZTO, and TiO2 coatings results in no discernible change to the infectivity of the coronavirus under the conditions tested. Thin-film Cu coatings are also applied to the polypropylene fabrics of N95 respirators, and droplet tests are performed. The Cu fabric coating reduces the infectivity of the virus; it results in a 1 order-of-magnitude reduction in the viral titer within 15 min with a 2 order-of-magnitude reduction after 1 h.
format	article
author	Louis-Vincent Delumeau Hatameh Asgarimoghaddam Tamiru Alkie Alexander James Bryan Jones Samantha Lum Kissan Mistry Marc G. Aucoin Stephanie DeWitte-Orr Kevin P. Musselman
author_facet	Louis-Vincent Delumeau Hatameh Asgarimoghaddam Tamiru Alkie Alexander James Bryan Jones Samantha Lum Kissan Mistry Marc G. Aucoin Stephanie DeWitte-Orr Kevin P. Musselman
author_sort	Louis-Vincent Delumeau
title	Effectiveness of antiviral metal and metal oxide thin-film coatings against human coronavirus 229E
title_short	Effectiveness of antiviral metal and metal oxide thin-film coatings against human coronavirus 229E
title_full	Effectiveness of antiviral metal and metal oxide thin-film coatings against human coronavirus 229E
title_fullStr	Effectiveness of antiviral metal and metal oxide thin-film coatings against human coronavirus 229E
title_full_unstemmed	Effectiveness of antiviral metal and metal oxide thin-film coatings against human coronavirus 229E
title_sort	effectiveness of antiviral metal and metal oxide thin-film coatings against human coronavirus 229e
publisher	AIP Publishing LLC
publishDate	2021
url	https://doaj.org/article/1a933bebcd8741ee9fb87a311d7fcec7
work_keys_str_mv	AT louisvincentdelumeau effectivenessofantiviralmetalandmetaloxidethinfilmcoatingsagainsthumancoronavirus229e AT hatamehasgarimoghaddam effectivenessofantiviralmetalandmetaloxidethinfilmcoatingsagainsthumancoronavirus229e AT tamirualkie effectivenessofantiviralmetalandmetaloxidethinfilmcoatingsagainsthumancoronavirus229e AT alexanderjamesbryanjones effectivenessofantiviralmetalandmetaloxidethinfilmcoatingsagainsthumancoronavirus229e AT samanthalum effectivenessofantiviralmetalandmetaloxidethinfilmcoatingsagainsthumancoronavirus229e AT kissanmistry effectivenessofantiviralmetalandmetaloxidethinfilmcoatingsagainsthumancoronavirus229e AT marcgaucoin effectivenessofantiviralmetalandmetaloxidethinfilmcoatingsagainsthumancoronavirus229e AT stephaniedewitteorr effectivenessofantiviralmetalandmetaloxidethinfilmcoatingsagainsthumancoronavirus229e AT kevinpmusselman effectivenessofantiviralmetalandmetaloxidethinfilmcoatingsagainsthumancoronavirus229e
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Effectiveness of antiviral metal and metal oxide thin-film coatings against human coronavirus 229E

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