A Review of Advanced Impedance Biosensors with Microfluidic Chips for Single-Cell Analysis
Electrical impedance biosensors combined with microfluidic devices can be used to analyze fundamental biological processes for high-throughput analysis at the single-cell scale. These specialized analytical tools can determine the effectiveness and toxicity of drugs with high sensitivity and demonst...
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MDPI AG
2021
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oai:doaj.org-article:1a9e2b3de5af4ccb830b67e1ba66c7a62021-11-25T16:54:53ZA Review of Advanced Impedance Biosensors with Microfluidic Chips for Single-Cell Analysis10.3390/bios111104122079-6374https://doaj.org/article/1a9e2b3de5af4ccb830b67e1ba66c7a62021-10-01T00:00:00Zhttps://www.mdpi.com/2079-6374/11/11/412https://doaj.org/toc/2079-6374Electrical impedance biosensors combined with microfluidic devices can be used to analyze fundamental biological processes for high-throughput analysis at the single-cell scale. These specialized analytical tools can determine the effectiveness and toxicity of drugs with high sensitivity and demonstrate biological functions on a single-cell scale. Because the various parameters of the cells can be measured depending on methods of single-cell trapping, technological development ultimately determine the efficiency and performance of the sensors. Identifying the latest trends in single-cell trapping technologies afford opportunities such as new structural design and combination with other technologies. This will lead to more advanced applications towards improving measurement sensitivity to the desired target. In this review, we examined the basic principles of impedance sensors and their applications in various biological fields. In the next step, we introduced the latest trend of microfluidic chip technology for trapping single cells and summarized the important findings on the characteristics of single cells in impedance biosensor systems that successfully trapped single cells. This is expected to be used as a leading technology in cell biology, pathology, and pharmacological fields, promoting the further understanding of complex functions and mechanisms within individual cells with numerous data sampling and accurate analysis capabilities.Soojung KimHyerin SongHeesang AhnTaeyeon KimJihyun JungSoo Kyung ChoDong-Myeong ShinJong-ryul ChoiYoon-Hwae HwangKyujung KimMDPI AGarticleimpedance sensormicrofluidic chipbiosensorsingle cell trappingBiotechnologyTP248.13-248.65ENBiosensors, Vol 11, Iss 412, p 412 (2021) |
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DOAJ |
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DOAJ |
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EN |
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impedance sensor microfluidic chip biosensor single cell trapping Biotechnology TP248.13-248.65 |
| spellingShingle |
impedance sensor microfluidic chip biosensor single cell trapping Biotechnology TP248.13-248.65 Soojung Kim Hyerin Song Heesang Ahn Taeyeon Kim Jihyun Jung Soo Kyung Cho Dong-Myeong Shin Jong-ryul Choi Yoon-Hwae Hwang Kyujung Kim A Review of Advanced Impedance Biosensors with Microfluidic Chips for Single-Cell Analysis |
| description |
Electrical impedance biosensors combined with microfluidic devices can be used to analyze fundamental biological processes for high-throughput analysis at the single-cell scale. These specialized analytical tools can determine the effectiveness and toxicity of drugs with high sensitivity and demonstrate biological functions on a single-cell scale. Because the various parameters of the cells can be measured depending on methods of single-cell trapping, technological development ultimately determine the efficiency and performance of the sensors. Identifying the latest trends in single-cell trapping technologies afford opportunities such as new structural design and combination with other technologies. This will lead to more advanced applications towards improving measurement sensitivity to the desired target. In this review, we examined the basic principles of impedance sensors and their applications in various biological fields. In the next step, we introduced the latest trend of microfluidic chip technology for trapping single cells and summarized the important findings on the characteristics of single cells in impedance biosensor systems that successfully trapped single cells. This is expected to be used as a leading technology in cell biology, pathology, and pharmacological fields, promoting the further understanding of complex functions and mechanisms within individual cells with numerous data sampling and accurate analysis capabilities. |
| format |
article |
| author |
Soojung Kim Hyerin Song Heesang Ahn Taeyeon Kim Jihyun Jung Soo Kyung Cho Dong-Myeong Shin Jong-ryul Choi Yoon-Hwae Hwang Kyujung Kim |
| author_facet |
Soojung Kim Hyerin Song Heesang Ahn Taeyeon Kim Jihyun Jung Soo Kyung Cho Dong-Myeong Shin Jong-ryul Choi Yoon-Hwae Hwang Kyujung Kim |
| author_sort |
Soojung Kim |
| title |
A Review of Advanced Impedance Biosensors with Microfluidic Chips for Single-Cell Analysis |
| title_short |
A Review of Advanced Impedance Biosensors with Microfluidic Chips for Single-Cell Analysis |
| title_full |
A Review of Advanced Impedance Biosensors with Microfluidic Chips for Single-Cell Analysis |
| title_fullStr |
A Review of Advanced Impedance Biosensors with Microfluidic Chips for Single-Cell Analysis |
| title_full_unstemmed |
A Review of Advanced Impedance Biosensors with Microfluidic Chips for Single-Cell Analysis |
| title_sort |
review of advanced impedance biosensors with microfluidic chips for single-cell analysis |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/1a9e2b3de5af4ccb830b67e1ba66c7a6 |
| work_keys_str_mv |
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